Attention deficit hyperactivity disorder

A person is diagnosed with ADHD if they have at least 6 symptoms from the following categories, lasting for at least 2 months. In diagnosing children, the symptoms must appear before age 7, and pose a significant challenge to everyday functioning in at least two areas of life (usually home and school). Most children do not show all the symptoms, and they may be different in boys and girls (boys may be more hyperactive and girls more inattentive).

Inattention

• Fails to pay close attention to details or makes careless mistakes
• Has difficulty sustaining attention in tasks or play activities
• Does not seem to listen when spoken to directly
• Does not follow through on instructions and fails to finish tasks
• Has difficulty organizing tasks and activities
• Avoids, dislikes, or is reluctant to engage in tasks that require sustained mental effort (such as school work)
• Loses things needed for tasks or activities
• Is easily distracted
• Is forgetful in daily activities

Hyperactivity and Impulsivity

• Fidgets with hands or feet or squirms when seated
• Does not remain seated when expected to
• Runs or climbs excessively in inappropriate situations (in teens or adults, may be feelings of restlessness)
• Has difficulty playing or engaging in leisure activities quietly
• Acts as if "driven by a motor"
• Talks excessively
• Blurts out answers before questions are completed
• Has difficulty waiting his or her turn
• Interrupts or intrudes on others

No one is sure what causes ADHD. Although environmental factors may play a role, researchers are now looking to find answers in the structure of the brain.

• Altered brain function. Brain scans show differences in the brains of children with ADHD compared to those of non-ADHD children. For example, many children with ADHD tend to have altered brain activity in the prefrontal cortex, a part of the brain known as the command center. This may affect their ability to control impulsive and hyperactive behaviors. Researchers also believe hyperactive behavior in children can be caused by too much slow wave (or theta) activity in certain regions of the brain.
• Genetics. ADHD seems to run in families.
• Maternal or childhood exposure to certain toxins. Women who smoke, drink, and are exposed to PCBs during pregnancy are more likely to have children with ADHD. Children who are exposed to lead, PCBs, or phthalates are more likely to develop the disorder.
• Pre-term birth. Up to 20% of babies who are born prematurely develop ADHD.

Risk factors for ADHD include:

• Heredity. Children with ADHD usually have at least one first-degree relative who also has the disorder.
• Gender. ADHD is 4 to 9 times more common in boys than in girls. Some experts believe that the disorder is underdiagnosed in girls, however, and recent studies show no association between a child's sex and ADHD.
• Prenatal and early postnatal health.
• Maternal drug, alcohol, and cigarette use.
• Exposure of the fetus or infant to toxins, including lead and PCBs.
• Nutritional deficiencies and imbalances.
• Pre-term birth and low birth weight.
• Low Apgar scores at birth.
• Other behavioral disorders, especially those that involve too much aggression (such as oppositional defiant or conduct disorder).

There is no objective test for ADHD, so making a diagnosis can be difficult. Doctors may use a number of tests and observations. For this reason, it is crucial to make sure the doctor who evaluates you or your child is trained in diagnosing ADHD.

To evaluate a child, the doctor will take a complete medical history and do a thorough exam to check for conditions that may mimic ADHD, such as hyperthyroidism or problems with vision, hearing, and sleeping. Many symptoms show up at home or school rather than the doctor's office, so you may be asked to fill out questionnaires. Your child's teacher may be interviewed. Your doctor will try to determine not only how the child behaves but also where the behavior occurs and how long it lasts. Children with ADHD have long-lasting symptoms that usually show up during stressful situations or situations that require sustained attention (such as school work).

Diagnosing an adult with ADHD can be even more challenging. Because your symptoms would have appeared when you were young, your doctor may try to find out as much as possible about you when you were a child by getting information from your parents or former teachers. (If your symptoms are recent, you are not considered to have adult ADHD.) In addition to ruling out the other conditions mentioned above, your doctor may also check for depression and bipolar disorder, which can mimic ADHD.

Since the cause or causes of ADHD are not known, there is no way to prevent the condition. However, pregnant women can avoid known risk factors, including cigarette smoke and other known toxins. You can manage the condition with medication, behavioral therapy, and lifestyle changes.

How to treat ADHD, particularly in children, is a controversial subject. Current treatment includes therapy or medication, or a combination of both. Studies show that medication by itself, without some kind of therapy, is not likely to improve a child's outcome long term. Family therapy, behavioral therapy, social skills training, and parent skills training are often used. Many parents investigate nutritional therapies (such as elimination diets or high-dose vitamins), however, there is no clear evidence to support these these approaches. Preliminary evidence indicates that homeopathy and mind/body techniques, especially biofeedback, may help improve behavior in children with ADHD.

Lifestyle

Parent skills training offered by specialized clinicians provides parents with tools and techniques for managing their child's behavior. Behavior therapy rewards appropriate behavior and discourages destructive behavior. It can be performed by parents and teachers working together with therapists and doctors. For example, older children with ADHD may be rewarded with points or tokens, or even written behavioral contracts with their parents. Creating charts with stars for good behavior may work for younger children. On the other hand, time-outs may discourage undesirable behavior. Other techniques include:

• Setting rules that are easily understood, developmentally appropriate, and not unduly harsh
• Avoiding repeated commands once the child has been reminded of the consequences
• Disciplining the child before becoming too angry and frustrated
• Following discipline with praise when the child follows the rules and behaves appropriately

In addition to behavioral intervention at home, changes in the classroom environment (or work, in the case of adolescents or adults) are significant parts of the treatment plan. Hyperactive children do best in highly structured circumstances with a teacher experienced in handling their disruptive behavior and capable of adapting to their distinctive cognitive style. Group interaction can be very challenging for a child with ADHD. Social skills training, appropriate classroom placement, and clear rules of engagement with peers are essential. Preliminary evidence suggests that computer-based attention training in schools is highly effective for students who have ADHD.

Adults with ADHD may benefit from behavioral therapies, including cognitive remediation, couples therapy, and family therapy.

Drug Therapies

Stimulant medications are the most widely-researched and commonly-prescribed treatments for ADHD. Although researchers do not fully understand how these drugs improve ADHD symptoms, studies indicate they boost the amount of dopamine and serotonin in the brain. Dopamine is a chemical that is associated with activity; and serotonin is a chemical associated with mood and well being. Medications prescribed for ADHD include:

Stimulants:

• Methylphenidate (Ritalin, Concerta). A stimulant and most commonly used medication for ADHD; effective in 75 to 80% of people with the condition; not recommended for children under 6 years of age
• Dextroamphetamine (Dexadrine). A stimulant that is effective in 70 to 75% of people with ADHD; not recommended for children under 3 years of age
• Amphetamine/Dextroamphetamine (Adderall)
• Lisdexamfetamine dimesylate (Vyvanse)

Atomoxetine (Strattera): The first nonstimulant medication approved to treat ADHD. Strattera increases the levels of both dopamine and norepinephrine in the brain. Strattera was first developed as an antidepressant and, as with all antidepressants, carries a "black box" warning that it may increase suicidal thoughts in young children and teenagers.

Antihypertensives (clonidine, guanfacone): These medications are not approved by the Food and Drug Administration (FDA) for the treatment of ADHD, however, they have been used off label for years. Antihypertensives are not as effective as stimulants, however, they are commonly used with stimulants to treat stimulant-induced tics and insomnia.

The most common side effects from these medications are trouble sleeping, decrease in appetite, and nervousness.

Complementary and Alternative Therapies

According to a recent survey, many parents use complementary and alternative treatments (CAM) for their children with ADHD. Nutritional therapies are the most common strategy. Studies show conflicting results, however, if your child appears sensitive to certain foods, talk to your doctor about eliminating them for a brief period to see if symptoms improve. DO NOT put a child on any supplement or CAM diet without the supervision of your doctor.

Diets

Developed in the 1970's by Benjamin Feingold, the Feingold diet is based on the idea that artificial colors, flavors, and preservatives, as well as naturally-occurring salicylates (chemicals similar to aspirin that are found in many fruits and vegetables), are a major cause of hyperactive behavior and learning disabilities in children. Studies examining the diet's effects have been mixed. Most show no benefit, although there is some evidence that salicylates may play a role in hyperactivity in a small number of children. Because the Feingold diet is difficult to follow, and also involves changes in family lifestyle (children are encouraged to participate in creating meals, for example), you should talk with your doctor before trying it.

Other dietary therapies may concentrate on eating foods that are high in protein and complex carbohydrates, and eliminating sugar and artificial sweeteners. One study found increased hyperactivity among children after eating foods with artificial food coloring and additives. However, studies show no relation between sugar and ADHD. In one study, children whose diets were high in sugar or artificial sweeteners behaved no differently than children whose diets were free of these substances. This was true even among children whose parents described them as being "sugar sensitive". However, some researchers believe that chronic excessive sugar intake leads to alterations in brain signaling, which would contribute to the symptoms associated with ADHD.

Some doctors who focus on nutrition say they see positive results when testing for food allergies and using an elimination diet. If you think your child might benefit from food allergy testing or an elimination diet, talk to a doctor who has experience in nutrition for children with ADHD.

Vitamins and Minerals

• Magnesium. Symptoms of magnesium deficiency include irritability, decreased attention span, and mental confusion. Some experts believe that children with ADHD may have a mild magnesium deficiency. In one preliminary study of 75 magnesium-deficient children with ADHD, those who received magnesium supplements showed an improvement in behavior compared to those who did not receive the supplements. Too much magnesium can be dangerous and magnesium can interfere with certain medications, including antibiotics and blood pressure medications. Talk to your doctor.
• Vitamin B6. The body needs sufficient vitamin B6 to make the brain chemicals affected in children with ADHD, including serotonin, dopamine, and norepinephrine. One preliminary study found that B6 pyridoxine was slightly more effective than Ritalin in improving behavior among hyperactive children. However, the study used a high dose of B6, which could cause nerve damage (although none occurred in the study). Other studies show that B6 has no effect on behavior. Because high doses can be dangerous, do not give your child B6, or take high doses yourself, without your doctor's supervision.
• Zinc. Zinc regulates the activity of brain chemicals, fatty acids, and melatonin, all of which are related to behavior. Several studies show that zinc may help improve behavior. Higher doses of zinc can be dangerous, so talk to your doctor before giving zinc to a child or taking it yourself.
• Essential fatty acids. Fatty acids, such as those found in fish and fish oil (omega-3 fatty acids) and evening primrose oil (omega-6 fatty acids), are "good fats" that play a key role in normal brain function. Study results are mixed. Omega-3 fatty acids are also good for heart health in adults, but high doses may increase the risk of bleeding. Talk to your doctor about the best dose.
• L-carnitine. L-carnitine is formed from an amino acid and helps cells in the body produce energy. One study found that 54% of a group of boys with ADHD showed improvement in behavior when taking L-carnitine. More research is needed. Because L-carnitine has not been studied for safety in children, talk to your doctor before giving a child L-carnitine. L-carnitine may make symptoms of hypothyroid worse, and may increase the risk of seizures in people who have had seizures before. It can also interact with some medications. Talk to your doctor.

Herbs

Herbs may help strengthen and tone the body's systems. As with any therapy, you should work with your health care provider before starting treatment. You may use herbs as dried extracts (capsules, powders, or teas), glycerites (glycerine extracts), or tinctures (alcohol extracts). Unless otherwise indicated, make teas with 1 tsp. herb per cup of hot water. Steep covered 5 to 10 minutes for leaf or flowers, and 10 to 20 minutes for roots. Drink 2 to 4 cups per day. You may use tinctures alone or in combination as noted.

Several herbal remedies for ADHD are sold in the United States and Europe, but few scientific studies have investigated whether these herbs improve symptoms of ADHD. One or more of the following calming herbs may be recommended for people with ADHD:

• Roman chamomile (Chamaemelum nobile). Chamomile may cause an allergic reaction in people sensitive to Ragweed. Chamomile may have estrogen-like effects in the body and therefore should be used with caution in people with hormone-related conditions, such as breast, uterine, or ovarian cancers, or endometriosis. Chamomile can also interact with certain medications; speak with your doctor.
• Valerian (Valerian officinalis). Valerian can potentially interact with certain medications. Since valerian can induce drowsiness, it may interact with sedative medications.
• Lemon balm (Melissa officinalis). Lemon balm may interact with sedative medications.
• Passionflower (Passiflora incarnata). Passionflower may interact with sedative medications.

Other herbs commonly contained in botanical remedies for ADHD include:

• Gingko (Gingko biloba). Used to improve memory and mental sharpness. Use gingko with caution if you have a history of diabetes, seizures, infertility, and bleeding disorders. Gingko can interact with many different medications, including but not limited to, blood-thinning medications.
• American ginseng (Panax quinquefolium) and gingko. One study suggests that gingko in combination with ginseng may improve symptoms of ADHD. Use American ginseng with caution if you have a history of diabetes, hormone-sensitive conditions, insomnia, or schizophrenia. It can interact with several medications, including but not limited to, blood-thinning medications.

Massage

Relaxation techniques and massage can reduce anxiety and activity levels in children and teens. In one study, teenage boys with ADHD who received a 15-minute massage for 10 consecutive school days showed significant improvement in behavior and concentration compared to those who were guided in progressive muscle relaxation for the same duration of time.

Homeopathy

Before prescribing a remedy, homeopaths take into account a person's constitutional type, includes your physical, emotional, and psychological makeup. An experienced homeopath assesses all of these factors when determining the most appropriate treatment for each individual.

In a study of 43 children with ADHD, those who received an individualized homeopathic remedy showed significant improvement in behavior compared to children who received placebo. The homeopathic remedies found to be most effective included:

• Stramonium. For children who are fearful, especially at night.
• Cina. For children who are irritable and dislike being touched; whose behavior is physical and aggressive.
• Hyoscyamus niger. For children who have poor impulse control, talk excessively, or act overly exuberant.

Biofeedback

Mind/body techniques such as hypnotherapy, progressive relaxation, and biofeedback may be useful in treating children and teens. Through these techniques, children are often able to learn coping skills they can use for the rest of their lives. These treatments allow children to gain a sense of control and mastery, increase self esteem, and reduce stress.

Biofeedback operates on the principle that children can be trained to modify brain activity associated with ADHD and increase brain activity associated with attention. Several studies have shown positive results.

Yoga

Preliminary studies suggest participating in yoga may help reduce symptoms of ADHD.

Prognosis and Complications

As many as half of all children with ADHD who receive appropriate treatment learn to control symptoms and function well as adults. Research suggests that children who receive treatment that combines therapies such as medication, behavioral therapy, and biofeedback are less likely to have behavioral problems as they grow up. Nevertheless, studies show that ADHD persists into adulthood in 60 to 70% of people diagnosed with ADHD in childhood. In most cases, ADHD can be effectively managed throughout life.

American Academy of Pediatrics. Clinical practice guideline: diagnosis and evaluation of the child with attention-deficit/hyperactivity disorder. Pediatrics. 2000;105(5):1158-1170.

Arnold LE, Hurt E, Lofthouse N. Attention-deficit/hyperactivity disorder: dietary and nutritional treatments. Child Adolesc Psychiatr Clin N Am. 2013; 22(3):381-402.

Arnold LE, Pinkham SM, Votolato N. Does zinc moderate essential fatty acid and amphetamine treatment of attention deficit/hyperactivity disorder? J Child Adolesc Psychopharmacol. 2000;10:111-117.

Baumgaertel A. Alternative and controversial treatments for attention-deficit/hyperactivity disorder. Pediatr Clin of North Am. 1999;46(5):977-992.

Bekaroglu M, Aslan Y, Gedik Y. Relationships between serum free fatty acids and zinc, and attention deficit hyperactivity disorder: a research note. J Child Psychol Psychiatry. 1996;37(2):225-227.

Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Boston, Mass: Integrative Medicine Communications; 1998:160, 107.

Bope & Kellerman: Conn's Current Therapy 2013, 1st. ed. St. Louis, MO: Elsevier Saunders; 2012.

Burgess J, Stevens L, Zhang W, Peck L. Long-chain polyunsaturated fatty acids in children with attention-deficit hyperactivity disorder. Am J Clin Nutr. 2000; 71(suppl):327S-330S.

Childress AC, Berry SA. Pharamacotherapy of attention-deficit hyperactivity disorder in adolescents. Drugs. 2012; 72(3):309-325.

Daroff: Bradley's Neurology in Clinical Practice, 6th ed. Philadelphia, PA: Elsevier Saunders; 2012.

Farone S, Mick E. Molecular Genetics of Attention Deficit Hyperactivity Disorder. Psychiatric Clinics of North America. 2010;33(1).

Ferri: Ferri's Clinical Advisor 2015, 1st ed. St. Louis, MO: Elsevier Mosby; 2014.

Ferrin M, Moreno-granados JM, Salcedo-Marin MD, Ruiz-Veguilla M, Perez-Ayala V, Taylor E. Evaluation of a psychoeducation programme for parents of children and adolescents with ADHD: immediate and long-term effects using a blind randomized controlled trial. Eur Child Adolesc Psychiatry. 2014; 23(8):637-47.

Field T, Quintino O, Hernandez-Reif M, Koslovsky G. Adolescents with attention deficit hyperactivity disorder benefit from massage therapy. Adolescence. 1998;33(129):103-108.

Frei H, von Ammon K, Thurneysen A. Treatment of hyperactive children: increased efficiency through modifications of homeopathic diagnostic procedure. Homeopathy. 2006 Jul;95(3):163-370.

Gutgesell H, Atkins D, Barst R, et al. Cardiovascular monitoring of children and adolescents receiving psychotropic drugs: a statement for healthcare professionals from the Committee on Congenital Cardiac Defects, Council on Cardiovascular Disease in the Young, American Heart Association. Circulation. 1999; 99(7):979-982.

Hariprasad VR, Arasappa R, Varambally S, Srinath S, Gangadhar BN. Feasibility and efficacy of yoga as an add-on intervention in attention deficity-hyperactivity disorder: An exploratory study. Indian J Psychiatry. 2013; 55(Suppl 3):S379-84.

Heinrich H, Gevensleben H, Strehl U. Annotation: neurofeedback - train your brain to train behaviour. J Child Psychol Psychiatry. 2007 Jan;48(1):3-16.

Holtmann M, Stadler C. Electroencephalographic biofeedback for the treatment of attention-deficit hyperactivity disorder in childhood and adolescence. Expert Rev Neurother. 2006 Apr;6(4):533-40. Review.

Johnson RJ, Gold MS, Johnson DR, et al. Attention-deficit/hyperactivity disorder: is it time to reappraise the role of sugar consumption? Postgrad Med. 2011; 123(5):39-49.

Kaplan G, Newcorn J. Pharmacotherapy for Child and Adolescent Attention-deficit Hyeractivity Disorder. Pediatric Clinics of North America. Philadelphia, PA: W. B. Saunders Company. 2011;58(1).

Kidd P. Attention deficit / hyperactivity disorder (ADHD) in children: rationale for its integrative management. Altern Med Rev. 2000;5(5):402-428.

Kim BN et al. Phthalates exposure and attention-deficit/hyperactivity disorder in school-age children. Biol Psych. 2009;66(10):958-963.

Kliegman: Nelson Textbook of Pediatrics, 19th ed. Philadelphia, PA: Elsevier Saunders; 2011.

Kozielec T, Starobrat-Hermelin B. Assessment of magnesium levels in children with attention deficit hyperactivity disorder. Magnes Res. 1997;10(2):143-148.

Krummel D, Seligson FH, Guthrie HA. Hyperactivity: is candy causal? Critical Reviews in Food Science and Nutrition. 1996;36(1 and 2):31-47.

Lamont J. Homoeopathic treatment of attention deficit hyperactivity disorder; a controlled study. Br Homoeopath J. 1997;86:196-200.

Lavigne JP, Dulcan MK, LeBailly SA, Binns HJ, Cummins TK, Jha P. Computer-assisted management of attention-deficit/hyperactivity disorder. Pediatrics. 20011; 128(1):e46-53.

Li J, Olsen J, Vestergaard M, Obel C. Low Apgar scores and risk of childhood attention deficit hyperactivity disorder. J Pediatr. 2011; 158(5):775-779.

Linden M, Habib T, Rodojevic V. A controlled study of the effects of EEG biofeedback on cognition and behavior of children with attention deficit disorder and learning disabilities. Biofeedback Self Regul. 1996;21(1):35-49.

Lindstrom K, Lindblad F; Hjern A. Preterm birth and attention-deficit/hyperactivity disorder in schoolchildren. Pediatrics. 2011; 127(5):858-865.

Lubar J, Swartwood MO, Swartwood JN, O'Donnell PH. Evaluation of the effectiveness of EEG neurofeedback training for ADHD in a clinical setting as measured by changes in TOVA scores, behavioral ratings and WISC-R performance. Biofeedback Self Regul. 1995;20(1):83-99.

Lyon MR, Cline JC, Totosy de Zepetnek J, et al. Effect of the herbal extract combination Panax quinquefolium and Ginkgo biloba on attention-deficit hyperactivity disorder: a pilot study. J Psychiatry Neurosci. 2001;26(3):221-228.

Millichap JG, Yee MM. The diet factor in attention-deficit/hyperactivity disorder. Pediatrics. 2012; 129(2):330-337.

Modesto-Lowe V, Yelunina L, Hanjan K. Attention-deficit/hyperactivity disorder: a shift toward resilience? Clin Pediatr (Phil). 2011; 50(6):518-524.

MTA Cooperative Group. A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. Arch Gen Psychiatry. 1999;56:1073-1086.

Nigg JT, Nikolas M, Knottnerus M, Cavanaugh K, Friderici K. Confirmation and extension of association of blood lead with attention deficit/hyperactivity disorder (ADHD) and ADHD symptom domains at population-typical exposure levels. J Child Psychol Psychiatry. 2010;51(1):58-65.

Noorbala AA, Akhondzadeh S. Attention-deficit/hyperactivity disorder: etiology and pharmacotherapy. Arch Iran Med. 2006 Oct;9(4):374-380. Review.

Post RE, Kurlansik SL. Diagnosis and management of adult attention-deficit/hyperactivity disorder. Am Fam Physician. 2012; 85(9):890-896.

Rader R, McCauley L, Callen E. Current Strategies in the Diagnosis and Treatment of Childhood Attention Deficit Hyperactivity Disorder. Am Fam Phys. 2009;79(8).

Raishevich N, Jensen P. Attention-deficit hyperactivity disorder. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF , eds. Nelson Textbook of Pediatrics. 18^th ed. Philadelphia, PA: W.B. Saunders Company; 2007:ch. 31.

Rakel: Integrative Medicine, 3rd ed. Philadelphia, PA: Elsevier Saunders; 2012.

Richardson AJ. Omega-3 fatty acids in ADHD and related neurodevelopmental disorders. Int Rev Psychiatry. 2006 Apr;18(2):155-172. Review.

Richardson AJ, Puri BK. The potential role of fatty acids in attention-deficit/hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids. 2000;63(1/2):79-87.

Starobrat-Hermelin B, Kozielec T. The effects of magnesium physiological supplementation on hyperactivity in children with attention deficit hyperactive disorder (ADHD): positive response to magnesium oral loading test. Magnesium Research. 1997;10(2):149-156.

Steiner NJ, Sheldrick RC, Gotthelf D, Perrin EC. Computer-based attention training in the schools for children with attention deficit/hyperactivity disorder: a preliminary trial. Clin Pediatr (Phil). 2011;50(7):615-622.

Stevens LJ, Zentall SS, Abate ML, Kuczek T, Burgess JR. Omega-3 fatty acids in boys with behavior, learning and health problems. Physiol Behav. 1996;59(4/5):915-920.

Stevens LJ, Zentall SS, Deck JL, et al. Essential fatty acid metabolism in boys with attention-deficit hyperactivity disorder. Am J Clin Nutr. 1995;62:761-768.

Stubberfield TG, Wray JA, Parry TS. Utilization of alternative therapies in attention-deficit hyperactivity disorder. J Paediatr Child Health. 1999;35:450-453.

Sinn N. Nutritional and dietary influences on attention deficit hyperactivity disorder. Nutr Rev. 2008 Oct;66(10):558-68.

Tan G, Schneider S. Attention-deficit hyperactivity disorder: pharmacotherapy and beyond. Postgrad Med. 1997;101(5):201-222.

Thompson L, Thompson M. Neurofeedback combined with training in metacognitive strategies: effectiveness in students with ADD. Appl Psychophysiol Biofeedback. 1998;23(4):243-263.

Toplak ME, Connors L, Shuster J, Knezevic B, Parks S. Review of cognitive, cognitive-behavioral, and neural-based interventions for Attention-Deficit/Hyperactivity Disorder (ADHD). Clin Psychol Rev. 2008 Jun;28(5):801-823. Review.

Toren P, Eldar S, Sela BA, et al. Zinc deficiency in attention-deficit hyperactivity disorder. Biol Psychiatry. 1996; 40:1308-1310.

Uebel-von Sandersleben H, Rothenberger A, Albrecht B, Rothenberger LG, Klement S, Bock N. Ginkgo biloba extract EGb 761 in children with ADHD. Z Kinder Jugendpsychiatr Psychother. 2014; 42(5):337-47.

Van Oudheusden LJ, Scholte HR. Efficacy of carnitine in the treatment of children with attention-deficit hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids. 2002;76:33-38.

Volkow ND, Wang G, Fowler JS, et al. Therapeutic doses of oral methylphenidate significantly increase extracellular dopamine in the human brain. J Neurosci. 2001;15;21(2):RC121.

Weber W, Newmark S. Complementary and Alternative Medical Therapies for Attention Deficit Hyperactivity Disorder and Autism. Pediatric Clinics of North America. 2007;54(6).

Wender PH, Wolf LE, Wasserstein J. Adults with ADHD. An overview. Ann N Y Acad Sci. 2001;931:1-16.

Wolraich M. Addressing behavior problems among school-aged children: traditional and controversial approaches. Pediatr Rev. 1997;18(8):266-270.

Yorbik O, Ozdag MF, Olgun A, Senol MG, Bek S, Akman S. Potential effects of zinc on information processing in boys with attention deficit hyperactivity disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Apr 1;32(3):662-667.