Histoplasma skin test
Histoplasmosis skin test
The histoplasma skin test is used to check if you have been exposed to a fungus called Histoplasma capsulatum. The fungus causes an infection called histoplasmosis.
The aspergillus antigen skin test determines whether or not a person has been exposed to the mold aspergillus. It is performed by injecting an aspergillus antigen under the skin with a needle. After 48 to 72 hours the site of injection is evaluated by a physician. If a positive reaction occurs (the test site is inflamed), the person has been exposed to the aspergillus mold and is at risk for developing aspergillosis.
How the Test is Performed
The health care provider cleans an area of your skin, usually the forearm. An allergen is injected just below the cleaned skin surface. An allergen is a substance that causes an allergic reaction. The injection site is checked at 24 hours and at 48 hours for signs of a reaction. Occasionally, the reaction may not appear until the fourth day.
How to Prepare for the Test
No special preparation is necessary for this test.
How the Test will Feel
You may feel a brief sting as the needle is inserted just below the skin.
Why the Test is Performed
This test is used to determine if you have been exposed to the fungus that causes histoplasmosis.
Normal Results
No reaction (inflammation) at the site of the test is normal. The skin test can rarely make histoplasmosis antibody tests turn positive.
Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your provider about the meaning of your specific test results.
What Abnormal Results Mean
A reaction means you have been exposed to Histoplasma capsulatum. It does not mean you have an active infection.
Risks
There is a slight risk of
Considerations
This test is rarely used today. It has been replaced by a variety of blood and urine tests.
References
Deepe GS. Histoplasma capsulatum (histoplasmosis). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 263.
Iwen PC, Thompson GR, Wiederhold NP. Mycotic diseases. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 60.
Version Info
Last reviewed on: 9/1/2021
Reviewed by: Jatin M. Vyas, MD, PhD, Associate Professor in Medicine, Harvard Medical School; Associate in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
