Malaise
General ill feeling
Malaise is a general feeling of discomfort, illness, or lack of well-being.

A lot of things can make you cough. Breathing in cigarette smoke, smelling a coworkers flowery perfume, or being sick with an infection can all leave you hacking. One of the infections that causes coughing is called bronchitis. Bronchitis is inflammation in the airways that lead to the lung. If you've got bronchitis, there's a good chance you started out with a respiratory infection like a cold, and it spread to your lungs. Either a virus or bacteria can cause this infection. The cough may clear up within a few days, but if it lingers for at least 3 months it's called chronic bronchitis. Chronic bronchitis is part of a group of lung diseases known as chronic obstructive pulmonary disease, or COPD for short. Smoking is one of the biggest causes of bronchitis and COPD. If you have bronchitis, you'll cough, and cough, and cough. In fact, the cough can stick with you for weeks. When you cough, you may bring up a sticky goo called mucus. If the mucus is yellow-green in color, that makes us think it might be a bacterial infection. Other symptoms of bronchitis include chest pain, wheezing, shortness of breath, and fatigue. To find out if you have bronchitis, your doctor will listen for crackly sounds in your chest when you breathe. You may also need a chest x-ray or other tests to see how well your lungs are working. So, how is bronchitis treated? Antibiotics won't treat bronchitis if a virus caused it, because they only kill bacteria. If you have a bacterial infection, you can take an antibiotic. The best way to get over bronchitis are with rest and time. While your lungs are healing, drink plenty of fluids and perhaps use a humidifier to loosen up mucus. Whatever else you do, don't smoke or be around anyone who is smoking or smells like smoke. The smoke will only make your cough worse. Bronchitis often clears up within a week or so, but the cough can stick around for weeks, or even months later, especially if you have a lung problem. While you're sick, call your doctor if you start to run a high fever, you feel short of breath or have chest pain, or your cough just won't go away. You can help protect yourself against bronchitis by washing your hands often, getting a pneumonia vaccine, and getting a flu vaccine each year to prevent some of the diseases that cause it. Be kind to your lungs by staying far away from cigarettes. If you need help kicking the habit, see your doctor.

If you often feel sad, blue, unhappy, miserable, or down in the dumps, you may have depression. Let's talk about depression, and what you can do to get out of your funk. Depression often runs in families. This may be due to your genes, passed down by your parents and grandparents, the behaviors you learn at home, or both. Even if your genetic makeup makes you more likely to develop depression, a stressful or unhappy life event may triggers the depression. Depression can have many causes, including internal factors like genetics, or negative personality. External factors, substance misuse, or trauma and loss. Common triggers include alcohol or drug use, and medical problems long-term pain, cancer or even sleeping problems. Stressful life events, like getting laid off, abuse at home or on the job, neglect, family problems, death of a loved one, or divorce, can send someone spiraling into depression. There are three main types of depression; major depression, atypical depression and dysthymia. To be diagnosed with major depression, you must demonstrate 5 or more of the primary symptoms for at least two weeks. Atypical depression occurs in about a third of patients with depression, with symptoms including overeating, oversleeping, and feeling like you are weighed down. Dysthymia is a milder form of depression that can last for years if not treated. Other forms include the depression that is part of bipolar disorder, postpartum depression, occurring after a woman gives birth, premenstrual dysphoric disorder, occurring 1 week before a woman's menstrual period and seasonal affective disorder, occurring in both males and females during the fall and winter seasons. No matter what type of depression you have and how severe it is, some self-care steps can help. Get enough sleep if you can, exercise regularly, and follow a healthy, nutritious diet. Avoid alcohol and recreational drugs. Get involved in activities that make you happy and spend time with family and friends. If you are religious, talk to a clergy member. Consider meditation, tai chi, or other relaxation methods. If you are depressed for 2 weeks or longer, contact your doctor or other health professional before your symptoms get worse. Treatment will depend on your symptoms. For mild depression, counseling and self-care may be enough. Either psychotherapy or antidepressant medicines may help, but they are often more effective when combined. Vigorous exercise and light therapy could offer significant benefit alone or in combination. Healthy lifestyle habits can help prevent and treat depression, and reduce the chances of it coming back. Talk therapy and antidepressant medication can also make you less likely to become depressed again. In fact, talk therapy may help you through times of grief, stress, or low mood. In general, staying active, making a difference in the life of others, getting outside and keeping in close contact with other people is important for preventing depression.

Bronchitis is the inflammation of the bronchi, the main air passages to the lungs. It often results from a respiratory infection caused by a virus or bacteria. Symptoms include coughing, shortness of breath, wheezing and fatigue.
Considerations
Malaise is a symptom that can occur with almost any health condition. It may start slowly or quickly, depending on the type of disease.
Fatigue (feeling tired) occurs with malaise in many diseases. You can have a feeling of not having enough energy to do your usual activities.
Causes
The following lists give examples of the diseases, conditions, and medicines that can cause malaise.
SHORT-TERM (ACUTE) INFECTIOUS DISEASE
- Acute bronchitis or pneumonia
- Acute viral syndrome
- COVID-19
- Infectious mononucleosis (EBV)
- Influenza
- Lyme disease
LONG-TERM (CHRONIC) INFECTIOUS DISEASE
- AIDS
- Chronic active hepatitis
- Disease caused by parasites
- Tuberculosis
HEART AND LUNG (CARDIOPULMONARY) DISEASE
ORGAN FAILURE
- Acute or chronic kidney disease
- Acute or chronic liver disease
CONNECTIVE TISSUE DISEASE
ENDOCRINE or METABOLIC DISEASE
- Adrenal gland dysfunction
- Diabetes
- Pituitary gland dysfunction (rare)
- Thyroid disease
CANCER
- Leukemia
- Lymphoma (cancer that starts in the lymph system)
- Solid tumor cancers, such as colon cancer
BLOOD DISORDERS
- Severe anemia
PSYCHIATRIC
MEDICINES
- Anticonvulsant (antiseizure) medicines
- Antihistamines
- Beta blockers (medicines used to treat heart disease or high blood pressure)
- Psychiatric medicines
- Treatments involving several medicines
Home Care
Contact your health care provider right away if you have severe malaise.
When to Contact a Medical Professional
Contact your provider if:
- You have other symptoms with the malaise
- Malaise lasts longer than one week, with or without other symptoms
What to Expect at Your Office Visit
Your provider will perform a physical exam and ask questions such as:
- How long has this feeling lasted (weeks or months)?
- What other symptoms do you have?
- Is the malaise constant or episodic (comes and goes)?
- Can you complete your daily activities? If not, what limits you?
- Have you traveled recently?
- What medicines are you taking?
- What are your other medical problems?
- Do you use alcohol or other drugs?
You may have tests to confirm the diagnosis if your provider thinks the problem may be due to an illness. These may include blood tests, x-rays, or other diagnostic tests.
Your provider will recommend treatment if needed based on your exam and tests.
References
Melia MT. Approach to fever or suspected infection in the normal host. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 259.
Nield LS, Kamat D. Fever. In: Kliegman RM, St. Geme JW, Blum NJ, et al, eds. Nelson Textbook of Pediatrics. 22nd ed. Philadelphia, PA: Elsevier; 2025:chap 219.
Simel DL. History and physical examination. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 6.
Version Info
Last reviewed on: 1/1/2025
Reviewed by: Linda J. Vorvick, MD, Clinical Professor Emeritus, Department of Family Medicine, UW Medicine, School of Medicine, University of Washington, Seattle, WA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
