Recombinant zoster (shingles) vaccine, RZV - what you need to know
All content below is taken in its entirety from the CDC Recombinant Shingles Vaccine Information Statement (VIS):
CDC review information for Recombinant Shingles VIS:
- Page last reviewed: October 30, 2019
- Page last updated: October 30, 2019
- Issue date of VIS: October 30, 2019
Why get vaccinated?
Recombinant zoster (shingles) vaccine can prevent shingles.
Shingles (also called herpes zoster, or just zoster) is a painful skin rash, usually with blisters. In addition to the rash, shingles can cause fever, headache, chills, or upset stomach. More rarely, shingles can lead to pneumonia, hearing problems, blindness, brain inflammation (encephalitis), or death.
The most common complication of shingles is long-term nerve pain called postherpetic neuralgia (PHN). PHN occurs in the areas where the shingles rash was, even after the rash clears up. It can last for months or years after the rash goes away. The pain from PHN can be severe and debilitating.
About 10% to 18% of people who get shingles will experience PHN. The risk of PHN increases with age. An older adult with shingles is more likely to develop PHN and have longer lasting and more severe pain than a younger person with shingles.
Shingles is caused by the varicella zoster virus, the same virus that causes chickenpox. After you have chickenpox, the virus stays in your body and can cause shingles later in life. Shingles cannot be passed from one person to another, but the virus that causes shingles can spread and cause chickenpox in someone who had never had chickenpox or received chickenpox vaccine.
Recombinant shingles vaccine
Recombinant shingles vaccine provides strong protection against shingles. By preventing shingles, recombinant shingles vaccine also protects against PHN.
Recombinant shingles vaccine is the preferred vaccine for the prevention of shingles. However, a different vaccine, live shingles vaccine, may be used in some circumstances.
The recombinant shingles vaccine is recommended for adults 50 years and older without serious immune problems. It is given as a two-dose series.
This vaccine is also recommended for people who have already gotten another type of shingles vaccine, the live shingles vaccine. There is no live virus in this vaccine.
Shingles vaccine may be given at the same time as other vaccines.
Talk with your health care provider
Tell your vaccine provider if the person getting the vaccine:
- Has had an allergic reaction after a previous dose of recombinant shingles vaccine, or has any severe, life-threatening allergies.
- Is pregnant or breastfeeding.
- Is currently experiencing an episode of shingles.
In some cases, your provider may decide to postpone shingles vaccination to a future visit.
People with minor illnesses, such as a cold, may be vaccinated. People who are moderately or severely ill should usually wait until they recover before getting recombinant shingles vaccine.
Your provider can give you more information.
Risks of a vaccine reaction
- A sore arm with mild or moderate pain is very common after recombinant shingles vaccine, affecting about 80% of vaccinated people. Redness and swelling can also happen at the site of the injection.
- Tiredness, muscle pain, headache, shivering, fever, stomach pain, and nausea happen after vaccination in more than half of people who receive recombinant shingles vaccine.
In clinical trials, about 1 out of 6 people who got recombinant zoster vaccine experienced side effects that prevented them from doing regular activities. Symptoms usually went away on their own in 2 to 3 days.
You should still get the second dose of recombinant zoster vaccine even if you had one of these reactions after the first dose.
People sometimes faint after medical procedures, including vaccination. Tell your provider if you feel dizzy or have vision changes or ringing in the ears.
As with any medicine, there is a very remote chance of a vaccine causing a severe allergic reaction, other serious injury, or death.
What if there is a serious problem?
An allergic reaction could occur after the vaccinated person leaves the clinic. If you see signs of a severe allergic reaction (hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, or weakness), call 9-1-1 and get the person to the nearest hospital.
For other signs that concern you, call your provider.
Adverse reactions should be reported to the Vaccine Adverse Event Reporting System (VAERS). Your provider will usually file this report, or you can do it yourself. Visit the VAERS website (
How can I learn more?
- Ask your provider. They can give you the vaccine package insert or suggest other sources of information.
- Contact your local or state health department.
- Contact the Centers for Disease Control and Prevention (CDC) by calling 1-800-232-4636 (1-800-CDC-INFO) or visiting CDC's vaccines website.
Centers for Disease Control and Prevention website. Recombinant shingles VIS.
Last reviewed on: 11/1/2019
Reviewed by: David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. Editorial update 11/1/2019.