Depression - stopping your medicines

If you often feel sad, blue, unhappy, miserable, or down in the dumps, you may have depression. Let's talk about depression, and what you can do to get out of your funk. Depression often runs in families. This may be due to your genes, passed down by your parents and grandparents, the behaviors you learn at home, or both. Even if your genetic makeup makes you more likely to develop depression, a stressful or unhappy life event may triggers the depression. Depression can have many causes, including internal factors like genetics, or negative personality. External factors, substance misuse, or trauma and loss. Common triggers include alcohol or drug use, and medical problems long-term pain, cancer or even sleeping problems. Stressful life events, like getting laid off, abuse at home or on the job, neglect, family problems, death of a loved one, or divorce, can send someone spiraling into depression. There are three main types of depression; major depression, atypical depression and dysthymia. To be diagnosed with major depression, you must demonstrate 5 or more of the primary symptoms for at least two weeks. Atypical depression occurs in about a third of patients with depression, with symptoms including overeating, oversleeping, and feeling like you are weighed down. Dysthymia is a milder form of depression that can last for years if not treated. Other forms include the depression that is part of bipolar disorder, postpartum depression, occurring after a woman gives birth, premenstrual dysphoric disorder, occurring 1 week before a woman's menstrual period and seasonal affective disorder, occurring in both males and females during the fall and winter seasons. No matter what type of depression you have and how severe it is, some self-care steps can help. Get enough sleep if you can, exercise regularly, and follow a healthy, nutritious diet. Avoid alcohol and recreational drugs. Get involved in activities that make you happy and spend time with family and friends. If you are religious, talk to a clergy member. Consider meditation, tai chi, or other relaxation methods. If you are depressed for 2 weeks or longer, contact your doctor or other health professional before your symptoms get worse. Treatment will depend on your symptoms. For mild depression, counseling and self-care may be enough. Either psychotherapy or antidepressant medicines may help, but they are often more effective when combined. Vigorous exercise and light therapy could offer significant benefit alone or in combination. Healthy lifestyle habits can help prevent and treat depression, and reduce the chances of it coming back. Talk therapy and antidepressant medication can also make you less likely to become depressed again. In fact, talk therapy may help you through times of grief, stress, or low mood. In general, staying active, making a difference in the life of others, getting outside and keeping in close contact with other people is important for preventing depression.
Before You Stop Your Medicine
Stopping your medicine may be the right choice for you. But first, you should talk with your health care provider. The safe way to stop taking this medicine is to lower the dose over time. If you stop taking the medicine suddenly, you are at risk for:
- Returning symptoms, such as severe depression
- Increased risk of suicide (for some people)
- Withdrawal symptoms, which could feel like the flu or produce sleep problems, dizziness, headache, anxiety, or irritability
Why Do You Want to Stop Taking This Medicine?
Write down all of the reasons you want to stop taking the medicine.
Do you still feel depressed? Is the medicine not working? If so, think about:
- What did you expect would change with this medicine?
- Have you been taking this medicine long enough for it to work?
If you have side effects, write down what they are and when they happen. Your provider may be able to adjust your medicine to improve these problems.
Do you have other concerns about taking this medicine?
- Are you having trouble paying for it?
- Does it bother you to have to take it every day?
- Does it bother you to think you have depression and need to take medicine for it?
- Do you think you should stop the medicine because you are feeling better (even though the medicine may be contributing to your improvement)?
- Do you think you should be able to deal with your feelings without medicine?
- Are others saying you do not need medicine or should not take it?
- Do you think the problem may be gone, and you wonder if you could stop the medicine now?
Making the Decision
Take your list of reasons to stop taking the medicine to your provider who prescribed it. Talk about each point.
Then, ask your provider:
- Do we agree on our treatment goals?
- What are the benefits of staying on this medicine now?
- What are the risks of stopping this medicine now?
Find out whether there are other things you can do to address your reasons for stopping the medicine, such as:
- Changing the dose of the medicine
- Changing the time of day you take the medicine
- Changing how you take the medicine in relation to food
- Taking a different medicine instead
- Treating any side effects
- Adding another treatment, such as talk therapy
Get the information you need to make a good decision. Think about your health and what is important to you. This conversation with your provider will help you decide whether to:
- Keep taking the medicine
- Try changing something or adding something
- Stop taking the medicine now
If You Decide to Stop the Medicine
Make sure you understand what you need to do to stop the medicine safely. Ask your provider how to lower the dose of this medicine over time. Do not stop taking this medicine suddenly.
As you reduce the amount of medicine you take, write down any symptoms you feel and when you feel them. Then discuss these with your provider.
When to Call the Doctor
Depression or anxiety might not come back right away when you stop taking the medicine, but it may come back in the future. If you start to feel depressed or anxious again, contact your provider. You should also contact your provider if you have the withdrawal symptoms listed above. It is very important to get help if you have any thoughts of harming yourself or others.
References
American Psychiatric Association website. Depressive disorders. Diagnostic and Statistical Manual of Mental Disorders. 5th ed, Text Revision (DSM-5-TR), Washington, DC: American Psychiatric Association Publishing; 2022.
Fava M, Mischoulon D, Cassano P, Papakostas GI, Stern TA. Depressive disorders. In: Stern TA, Wilens TE, Fava M, eds. Massachusetts General Hospital Comprehensive Clinical Psychiatry. 3rd ed. Philadelphia, PA: Elsevier; 2025:chap 28.
National Institute of Mental Health website. Depression.
Version Info
Last reviewed on: 10/20/2024
Reviewed by: Fred K. Berger, MD, addiction and forensic psychiatrist, Scripps Memorial Hospital, La Jolla, CA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
