Whipple disease is a rare condition that mainly affects the small intestine. This prevents the small intestine from allowing nutrients to pass into the rest of the body. This is called malabsorption.
Whipple disease is caused by infection with bacterium called Tropheryma whipplei. The disorder mainly affects white men of middle-age.
Whipple disease is rare. Risk factors are not known.
Symptoms most often start slowly. Joint pain is the most common early symptom. Symptoms of gastrointestinal (GI) infection often occur several years later. Other symptoms may include:
Exams and Tests
The health care provider will perform a physical exam. This may show:
Tests to diagnose Whipple disease may include:
- Complete blood count (CBC)
- Polymerase chain reaction (PCR) test to check for the bacteria that cause the disease
- Small bowel biopsy
- Upper GI endoscopy (viewing the intestines with a flexible, lighted tube in a process called enteroscopy)
This disease may also change the results of the following tests:
People with Whipple disease need to take long-term antibiotics to cure the infection that may include sites in the brain and central nervous system. An antibiotic called ceftriaxone is given through a vein (IV). It is followed by another antibiotic (such as trimethoprim-sulfamethoxazole) taken by mouth for up to 1 year.
If symptoms come back during antibiotic use, the medicines may be changed.
Your provider should closely follow your progress. Symptoms of the disease can return after you finish the treatments. People who remain malnourished will also need to take dietary supplements.
If not treated, the condition is most often fatal. Treatment relieves symptoms and can cure the disease.
When to Contact a Medical Professional
Contact your provider if you have:
- Joint pain that does not go away
- Abdominal pain
If you are being treated for Whipple disease, contact your provider if:
- Symptoms get worse or do not improve
- Symptoms reappear
- New symptoms develop
Maiwald M,von Herbay A, Relman DA. Whipple disease. In:Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran'sGastrointestinal and Liver Disease. 11th ed.Philadelphia, PA: Elsevier; 2021:chap 109.
MarthT, Schneider T. Whipple disease. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett’s Principlesand Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier;2020:chap 210.
WestSG. Systemic diseases in which arthritis is a feature. In: Goldman L, SchaferAI, eds. Goldman-Cecil Medicine. 26thed. Philadelphia, PA: Elsevier; 2020:chap 259.
Last reviewed on: 5/4/2022
Reviewed by: Michael M. Phillips, MD, Emeritus Professor of Medicine, The George Washington University School of Medicine, Washington, DC. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.