Histiocytosis

Langerhans cell histiocytosis; Erdheim-Chester disease

Histiocytosis is a general name for a group of disorders or "syndromes" that involve an abnormal increase in the number of specialized white blood cells that are called histiocytes.

Recently, new knowledge about this family of diseases has led experts to develop a new classification. Five categories have been proposed:

  • L group -- includes Langerhans cell histiocytosis and Erdheim-Chester disease
  • C group -- includes non- Langerhans cell histiocytosis that involves the skin
  • M group -- includes malignant histiocytosis
  • R group -- includes Rosai-Dorfman disease
  • H Group -- includes hemophagocytic lymphohistiocytosis

This article focuses only on the L group, which includes Langerhans cell histiocytosis and Erdheim-Chester disease.

Eosinophilic granuloma - X-ray of the skull

This X-ray of the skull shows an eosinophilic granuloma (a lesion made-up of a type of white blood cell). This condition can range from a single eosinophilic granuloma to massive infiltration of skin, bone, and body organs.

Respiratory system

Air is breathed in through the nasal passageways, travels through the trachea and bronchi to the lungs.

Causes

Symptoms

Exams and Tests

Treatment

Support Groups

Outlook (Prognosis)

Possible Complications

When to Contact a Medical Professional

Prevention