Alpha-1 antitrypsin deficiency

AAT deficiency; Alpha-1 protease deficiency; COPD - alpha-1 antitrypsin deficiency; Cirrhosis - alpha-1 antitrypsin deficiency

Alpha-1 antitrypsin (A1AT) deficiency is a condition in which the body does not make enough of a protein that protects the lungs and liver from damage. The condition can lead to emphysema and liver disease (cirrhosis).


The major features of the lungs include the bronchi, the bronchioles and the alveoli. The alveoli are the microscopic blood vessel-lined sacks in which oxygen and carbon dioxide gas are exchanged.

Liver anatomy

The liver serves a wide variety of body functions, including detoxifying blood and producing bile that aids in digestion.



Exams and Tests


Outlook (Prognosis)

Possible Complications

When to Contact a Medical Professional