Fine needle aspiration of the thyroid
Thyroid nodule fine needle aspirate biopsy; Biopsy - thyroid - skinny-needle; Skinny-needle thyroid biopsy; Thyroid nodule - aspiration; Thyroid cancer - aspiration
Fine needle aspiration of the thyroid gland is a procedure to remove thyroid cells for examination. The thyroid gland is a butterfly-shaped gland located inside the front of the lower neck.
How the Test is Performed
This test may be done in the health care provider's office or in a hospital. Numbing medicine (anesthesia) may or may not be used. Because the needle is very thin, you may not need this medicine.
You lie on your back with a pillow under your shoulders with your neck extended. The biopsy site is cleaned. A thin needle is inserted into your thyroid, where it collects a sample of thyroid cells and fluid. The needle is then taken out. If the provider cannot feel the biopsy site, they may use ultrasound or a CT scan to guide where to put the needle. Ultrasound and CT scans are painless procedures that show images inside the body.
Pressure is applied to the biopsy site to stop any bleeding. The site is then covered with a bandage.
How to Prepare for the Test
Tell your provider if you have drug allergies, bleeding problems, or are pregnant. Also, make sure your provider has a current list of all medicines you take, including herbal remedies and over-the-counter drugs.
A few days to a week before your biopsy, you may be asked to temporarily stop taking blood-thinning medicines. The drugs you may need to stop taking include:
- Clopidogrel (Plavix)
- Ibuprofen (Advil, Motrin)
- Naproxen (Aleve, Naprosyn)
- Warfarin (Coumadin)
Be sure to talk with your provider before stopping any drugs.
How the Test will Feel
If numbing medicine is used, you may feel a sting as the needle is inserted and the medicine is injected.
As the biopsy needle passes into your thyroid, you may feel some pressure, but it should not be painful.
You may have slight discomfort in your neck afterward. You may also have slight bruising, which soon goes away.
Why the Test is Performed
A normal result shows the thyroid tissue looks normal and the cells do not appear to be cancer under a microscope.
What Abnormal Results Mean
Abnormal results may mean:
- Thyroid disease, such as goiter or thyroiditis
- Noncancerous tumors
- Thyroid cancer
The main risk is bleeding into or around the thyroid gland. With severe bleeding, there may be pressure on the windpipe (trachea). This problem is rare.
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Faquin WC, Fadda G, Cibas ES. Fine-needle aspiration of the thyroid gland: The 2017 Bethesda System. In: Randolph GW, ed. Surgery of the Thyroid and Parathyroid Glands. 3rd ed. Philadelphia, PA: Elsevier; 2021:chap 11.
Filetti S, Tuttle RM, Leboulleux S, Alexander EK. Nontoxic diffuse goiter, nodular thyroid disorders, and thyroid malignancies. In: Melmed S, Auchus, RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020:chap 14.
Last reviewed on: 2/28/2022
Reviewed by: Debra G. Wechter, MD, FACS, General Surgery Practice Specializing in Breast Cancer, Virginia Mason Medical Center, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.