Digoxin test
Heart failure - digoxin test
A digoxin test checks how much digoxin you have in your blood. Digoxin is a type of medicine called a cardiac glycoside. It is used to treat certain heart problems, although much less often than in the past.
Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand. A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. Preparation may vary depending on the specific test.
How the Test is Performed
How to Prepare for the Test
Ask your health care provider whether you should take your usual medicines before the test.
How the Test will Feel
When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing where the needle was inserted.
Why the Test is Performed
The main purpose of this test is to determine the best dosage of digoxin and prevent side effects.
It is important to monitor the level of digitalis medicines such as digoxin. That is because the difference between a safe treatment level and a harmful level is small.
Normal Results
In general, normal values range from 0.5 to 1.9 nanograms per milliliter of blood. But the right level for some people may vary depending on the situation.
The examples above are common measurements for results of these tests. Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your doctor about the meaning of your specific test results.
What Abnormal Results Mean
Abnormal results may mean you are getting too little or too much digoxin.
A very high value could mean that you have or are likely to develop a digoxin overdose (toxicity).
Risks
Risks associated with having blood drawn are slight but may include:
- Excessive bleeding
- Fainting or feeling lightheaded
- Hematoma (blood accumulating under the skin)
- Infection (a slight risk any time the skin is broken)
References
Aronson JK. Cardiac glycosides. In: Aronson JK, ed. Meyler's Side Effects of Drugs. 16th ed. Waltham, MA: Elsevier B.V.; 2016:117-157.
Koch R, Sun C, Minns A, Clark RF. Overdose of cardiotoxic drugs. In: Brown DL, ed. Cardiac Intensive Care. 3rd ed. Philadelphia, PA: Elsevier; 2019:chap 34.
Mann DL. Management of heart failure patients with reduced ejection fraction. In: Libby P, Bonow RO, Mann DL, Tomaselli GF, Bhatt DL, Solomon SD, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 12th ed. Philadelphia, PA: Elsevier; 2022:chap 50.
Version Info
Last reviewed on: 5/8/2022
Reviewed by: Michael A. Chen, MD, PhD, Associate Professor of Medicine, Division of Cardiology, Harborview Medical Center, University of Washington Medical School, Seattle, WA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
