Prostatitis - nonbacterial
NBP; Prostatodynia; Pelvic pain syndrome; CPPS; Chronic nonbacterial prostatitis; Chronic genitourinary pain
Chronic nonbacterial prostatitis causes long-term pain and urinary symptoms. It involves the prostate gland or other parts of a man's lower urinary tract or genital area. This condition is not caused by an infection with bacteria.
Possible causes of nonbacterial prostatitis include:
- A past bacterial prostatitis infection
- Bicycle riding
- Less common types of bacteria
- Irritation caused by a backup of urine flowing into the prostate
- Irritation from chemicals
- Nerve problem involving the lower urinary tract
- Pelvic floor muscle problem
- Sexual abuse
Life stresses and emotional factors may play a part in the problem.
Most men with chronic prostatitis have the nonbacterial form.
Exams and Tests
Most of the time, a physical exam is normal. However, the prostate may be swollen or tender.
Urine tests may show white or red blood cells in the urine. A semen culture may show a higher number of white blood cells and low sperm count with poor movement.
Urine culture or culture from the prostate does not show bacteria.
Treatment for nonbacterial prostatitis is difficult. The problem is hard to cure, so the goal is to control symptoms.
Several types of medicines may be used to treat the condition. These include:
- Long-term antibiotics to make sure that the prostatitis is not caused by bacteria. However, people who are not helped by antibiotics should stop taking these medicines.
- Drugs called alpha-adrenergic blockers help relax the muscles of the prostate gland. It often takes about 6 weeks before these medicines start working. Many people do not get relief from these medicines.
- Aspirin, ibuprofen, and other nonsteroidal anti-inflammatory drugs (NSAIDs), which may relieve symptoms for some men.
- Muscle relaxers like diazepam or cyclobenzaprine can help to reduce spasms in the pelvic floor.
Some people have found some relief from pollen extract (Cernitin) and allopurinol. But research does not confirm their benefit. Stool softeners may help reduce discomfort with bowel movements.
Surgery, called transurethral resection of the prostate, may be done in rare cases if medicine does not help. In most cases, this surgery is not done on younger men. It may cause retrograde ejaculation. This can lead to sterility, impotence, and incontinence.
Other treatments that may be tried include:
- Warm baths to ease some of the pain
- Prostate massage, acupuncture, and relaxation exercises
- Dietary changes to avoid bladder and urinary tract irritants
- Pelvic floor physical therapy
Many people respond to treatment. However, others do not get relief, even after trying many things. Symptoms often come back and may not be treatable.
Untreated symptoms of nonbacterial prostatitis may lead to sexual and urinary problems. These problems can affect your lifestyle and emotional well-being.
When to Contact a Medical Professional
Call your health care provider if you have symptoms of prostatitis.
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Kaplan SA. Benign prostatic hyperplasia and prostatitis. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 120.
McGowan CC. Prostatitis, epididymitis, and orchitis. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 110.
Nickel JC. Inflammatory and pain conditions of the male genitourinary tract: prostatitis and related pain conditions, orchitis, and epididymitis. In: Wein AJ, Kavoussi LR, Partin AW, Peters CA, eds. Campbell-Walsh Urology. 11th ed. Philadelphia, PA: Elsevier; 2016:chap 13.
Last reviewed on: 7/31/2019
Reviewed by: Sovrin M. Shah, MD, Assistant Professor, Department of Urology, The Icahn School of Medicine at Mount Sinai, New York, NY. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.