Anticonvulsant medications - miscellaneous
Taking carbamazepine may deplete calcium and vitamin B9. Deficiency of sodium may develop during the treatment with oxcarbazepine and eslicarbazepine.
Calcium, along with vitamin D, keeps your bones strong and healthy.
Low levels of calcium may cause:
- Muscle cramps
- Numbness or tingling in toes and feet
- Irregular heartbeat
- Bone pain
- Spinal problems
Vitamin B9 (Folic Acid)
Low levels of folic acid in the body may be linked to:
- Heart disease
- Birth defects
Symptoms may include:
- Mouth sores
- Swollen tongue
- Poor growth
Sodium deficiency is rare because it is widely available in dietary sources. When it does occur, low levels have been associated with:
- Nausea and vomiting
- Memory impairment
- Reduced attention
- Muscle cramps
- Strong, rapid or irregular heartbeat
- Lack of energy
Severe cases can cause seizures, loss of consciousness, and possibly coma. The development of symptoms depends on how fast you lose sodium.
The information presented here covers some of the nutrients that may be affected when you take certain medicines. If you have any of these signs and symptoms, it does not always mean you have low levels of these nutrients.
Factors that affect the level of nutrients are:
- Your medical history
- How long you have been taking the medicine
Please talk to your health care provider. They can best address your health care needs and see if you are at risk for low levels of any nutrients.
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Gold Standard Drug Database: Drug Monograph: Carbamazepine, 2016.
Gold Standard Drug Database: Drug Monograph: Eslicarbazepine, 2016.
Gold Standard Drug Database: Drug Monograph: Oxcarbazepine, 2016.
Gold Standard Drug Database: Drug Monograph: Rufinamide, 2016.
Greenbaum LA. Vitamin K deficiency. In: Kliegman RM, Stanton BF, St Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics. 20th ed. Philadelphia, PA: Elsevier; 2016:chap 53.
Pfennig CL, Slovis CM. Electrolyte disorders. In: Marx JA, Hockberger RS, Walls RM, eds. Rosen's Emergency Medicine. 8th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 125.
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