• Press Release

Mount Sinai Researchers Uncover a Key Neural Mechanism Believed to Support Advanced Cognitive Abilities

  • New York, NY
  • (December 21, 2021)

Mount Sinai scientists have discovered a neural mechanism that is believed to support advanced cognitive abilities such as planning and problem-solving. It does so by distributing information from single neurons to larger populations of neurons in the prefrontal cortex, the area of the brain that temporarily stores and manipulates information.

It is well established that humans can only hold a limited amount of information in mind at a time, and that they enlist different cognitive strategies, like organizing information into lists or groups, to overcome these constraints. The research team found that when the brain uses these strategies to organize information, neural codes in the prefrontal cortex become less dependent on the highly selective responses of single neurons. Instead, they become distributed among a larger pool of neurons, which may make the information more reliable or robust. The findings were published online in Neuron on December 20.

“Our study gives the field an important new perspective on how the brain allocates its resources to improve cognitive performance,” says senior author Erin Rich, MD, PhD, Associate Professor of Neuroscience at the Icahn School of Medicine at Mount Sinai. “Findings from our study will help scientists to better understand, and in the future to potentially treat, disorders of memory and cognition.”

The study was led by Feng-Kuei Chiang, PhD, a postdoctoral fellow in Dr. Rich’s lab who has previously studied functions of the prefrontal cortex in sequencing tasks.

Traditionally, studies of neural coding—which transforms electrical impulses from the neurons into memories, knowledge, decisions, and actions—have focused on selective responses of single neurons. The Mount Sinai team demonstrated the shortcomings of such an approach by designing a task to probe changes in the prefrontal cortex that result in improved cognitive performance. The task allowed the subjects to use a mnemonic (or memory aid) strategy to order information into a sequence.

“We found that subjects spontaneously generated different selection patterns, including routine sequences, to decrease the working memory demands of the task,” said Dr. Chiang.

Researchers were surprised to find that interpretable responses of single neurons were a poor predictor of memory performance when subjects used the sequencing strategy to organize information held in the mind. Using the strategy reduced error rates in the task, but the activity of single neurons appeared to convey less information. They were able to reconcile these findings by showing that the information was not lost, but more widely distributed among a larger population of neurons. The task-relevant information could be recovered as well or better than when the codes were dominated by a smaller number of highly tuned neurons, and the distributed codes appeared to be more reliable, since they improved behavioral performance.

“This is a brand-new discovery in the nature of prefrontal codes, and it could point to a key neural mechanism that supports advanced cognitive abilities like planning, strategizing, and problem-solving that depend on real-time organization of information,” explains Dr. Rich. “By shifting the focus from selective responses of single neurons, we’ve shown that the collective activity of neural populations needs to be considered when developing new strategies to improve cognitive performance or treat cognitive disorders.”


About the Mount Sinai Health System

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, over 400 outpatient practices, nearly 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it.

Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes approximately 7,300 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in 4 out of 10 pediatric specialties. The Icahn School of Medicine at Mount Sinai is one of three medical schools that have earned distinction by multiple indicators: It is consistently ranked in the top 20 by U.S. News & World Report's "Best Medical Schools," aligned with a U.S. News & World Report "Honor Roll" Hospital, and top 20 in the nation for National Institutes of Health funding and top 5 in the nation for numerous basic and clinical research areas. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

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