• Press Release

3D-Printed Trachea among Key Mount Sinai Research Presented at American Association for Thoracic Surgery Meeting

Icahn School of Medicine at Mount Sinai researchers presented several landmark studies at the 2015 American Association for Thoracic Surgery (AATS) meeting in Seattle. 

  • New York
  • (May 04, 2015)

Icahn School of Medicine at Mount Sinai researchers presented several landmark studies at the 2015 American Association for Thoracic Surgery (AATS) meeting in Seattle. 

AATS Highlights include: 

• First Successful 3D Printed Trachea 

A team of researchers from Icahn School of Medicine have combined 3D printing technology with human stem cells to create the first successful 3D-printed biologic tracheal graft in an animal model. Using a biocompatible polymer, researchers created a customized 3D-printed tracheal graft seeded with stem cells. The graft was then used to repair a defect in an animal. The Mount Sinai team continues to work toward creating a customized tracheal graft that could be used to repair complex airway defects in humans. 

"We are very pleased with our early results and look forward to continuing our work in this area," said Faiz Bhora, MD, Chief of Thoracic Surgery at Mount Sinai Roosevelt and Mount Sinai St. Luke’s, Associate Professor of Thoracic Surgery, Icahn School of Medicine. “The ability to produce a customized organ derived from biocompatible material or from a patient’s own stem cells is the new frontier in biomedical engineering and may represent a future permanent treatment for patients with tracheal injuries." Other key members of the team include Robert Lebovics, MD, chief of otolaryngology at Mount Sinai St. Luke's and Mount Sinai Roosevelt, Adnan Al-Ayoubi, MD, PhD, Sadiq Rehmani, MD, and Michael Barsky, BA, postdoctoral fellows in the thoracic surgery research lab. 

• Increased Mortality in Black Patients after Surgery for Esophageal Cancer 

In a study led by Andrea Wolf, MD, Assistant Professor of Thoracic Surgery at the School of Medicine, African-American patients with esophageal cancer were found to have higher rates of mortality after surgery compared to their white counterparts. Researchers analyzed patient outcomes data from the Survival Epidemiology and End Results (SEER) database to determine the impact of surgery. 

“We believe the disparity in survival may be attributed to the fact that blacks may not be staged adequately and lack access to more experienced, specialized thoracic surgeons,” said Dr. Wolf. “Further studies are needed to access whether skilled surgeons may improve survival in these patients.” 

• Is Surgical Resection Justified for Myasthenia Gravis? 

In a study led by Andrew J. Kaufman, MD, Assistant Professor of Thoracic Surgery at the School of Medicine, patients receiving surgical treatment for Myasthenia Gravis, a chronic autoimmune neuromuscular disease characterized by varying degrees of weakness of the skeletal muscles of the body, achieved stable remission and improvement of symptoms after surgery. Researchers analyzed more than 1,000 patients who underwent a Thymectomy to remove the thymus, a specialized organ of the immune system. 19% of patients achieved complete stable remission; an additional 16% experienced improvement in symptoms requiring less medication after; and 58% were stable after surgery but developed progressive disease. 

“Our analysis suggests surgery provides a significant chance of achieving complete and stable remission in many patients,” said Andrew J. Kaufman, MD, Assistant Professor of Medicine, Icahn School of Medicine at Mount Sinai, “Surgery should be considered for the treatment of myasthenia gravis, especially in those with mild symptoms."


About the Mount Sinai Health System

The Mount Sinai Health System is New York City's largest integrated delivery system, encompassing eight hospitals, a leading medical school, and a vast network of ambulatory practices throughout the greater New York region. Mount Sinai's vision is to produce the safest care, the highest quality, the highest satisfaction, the best access and the best value of any health system in the nation. The Health System includes approximately 7,480 primary and specialty care physicians; 11 joint-venture ambulatory surgery centers; more than 410 ambulatory practices throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and 31 affiliated community health centers. The Icahn School of Medicine is one of three medical schools that have earned distinction by multiple indicators: ranked in the top 20 by U.S. News & World Report's "Best Medical Schools", aligned with a U.S. News & World Report's "Honor Roll" Hospital, No. 12 in the nation for National Institutes of Health funding, and among the top 10 most innovative research institutions as ranked by the journal Nature in its Nature Innovation Index. This reflects a special level of excellence in education, clinical practice, and research. The Mount Sinai Hospital is ranked No. 14 on U.S. News & World Report's "Honor Roll" of top U.S. hospitals; it is one of the nation's top 20 hospitals in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Geriatrics, Gynecology, Nephrology, Neurology/Neurosurgery, and Orthopedics in the 2019-2020 "Best Hospitals" issue. Mount Sinai's Kravis Children's Hospital also is ranked nationally in five out of ten pediatric specialties by U.S. News & World Report. The New York Eye and Ear Infirmary of Mount Sinai is ranked 12th nationally for Ophthalmology, Mount Sinai St. Lukes and Mount Sinai West are ranked 23rd nationally for Nephrology and 25th for Diabetes/Endocrinology, and Mount Sinai South Nassau is ranked 35th nationally for Urology. Mount Sinai Beth Israel, Mount Sinai St. Luke's, Mount Sinai West, and Mount Sinai South Nassau are ranked regionally.

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