"Abnormalities in Genes Linked to IRSP in Alzheimer’s Disease"
Individuals with Alzheimer's disease (AD) have abnormalities and reductions in gene expression in the parahippocampal gyri that map to genes associated with the insulin receptor signaling pathway (IRSP), according to a study published online Nov. 1 in PLOS ONE. Pavel Katsel, PhD, associate professor of psychiatry at the Icahn School of Medicine at Mount Sinai, and colleagues examined IRSP and endothelial cell markers in the parahippocampal gyrus of 30 controls, 19 individuals with AD, and 34 individuals with AD and type 2 diabetes who had been treated with anti-diabetic drugs. "Given the dual epidemics of T2D and dementia in the most rapidly growing segment of our population, there is enormous importance in elucidating the basis for cognitive impairment in T2D so that potentially meaningful interventions can be evaluated," the authors write.
— Pavel L. Katsel, PhD, Associate Professor, Psychiatry, Icahn School of Medicine at Mount Sinai
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