Mount Sinai and USC Researchers Develop Prostate Cancer Prediction Tool That Has Unmatched Accuracy
Current tools used to predict prostate cancer progression are generally subjective in nature, leading to differing interpretations among clinicians
A team of researchers from the Icahn School of Medicine at Mount Sinai and Keck School of Medicine at the University of Southern California (USC) have developed a novel machine-learning framework that distinguishes between low- and high-risk prostate cancer with more precision than ever before. The framework, described in a Scientific Reports paper published today, is intended to help physicians—in particular, radiologists—more accurately identify treatment options for prostate cancer patients, lessening the chance of unnecessary clinical intervention.
Prostate cancer is one of the leading causes of cancer death in American men, second only to lung cancer. While recent advances in prostate cancer research have saved many lives, objective prediction tools have, until now, remained an unmet need.
Presently, the standard methods used to assess prostate cancer risk are multiparametric magnetic resonance imaging (mpMRI), which detects prostate lesions, and the Prostate Imaging Reporting and Data System, version 2 (PI-RADS v2), a five-point scoring system that classifies lesions found on the mpMRI. Together, these tools are intended to soundly predict the likelihood of clinically significant prostate cancer. However, PI-RADS v2 scoring is subjective and does not distinguish clearly between intermediate and malignant cancer levels (scores 3, 4, and 5), often leading to differing interpretations among clinicians.
Combining machine learning with radiomics—a branch of medicine that uses algorithms to extract large amounts of quantitative characteristics from medical images—has been proposed as an approach to remedy this drawback. However, other studies have only tested a limited number of machine learning methods to address this limitation. In contrast, the Mount Sinai and USC researchers developed a predictive framework that rigorously and systematically assessed many such methods to identify the best-performing one. The framework also leverages larger training and validation data sets than previous studies did. As a result, researchers were able to classify patients’ prostate cancer with high sensitivity and an even higher predictive value.
“By rigorously and systematically combining machine learning with radiomics, our goal is to provide radiologists and clinical personnel with a sound prediction tool that can eventually translate to more effective and personalized patient care,” said Gaurav Pandey, PhD, Assistant Professor of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai and senior corresponding author of the publication alongside co-corresponding author Bino Varghese, PhD, Assistant Professor of Research Radiology at the Keck School of Medicine at USC. “The pathway to predicting prostate cancer progression with high accuracy is ever improving, and we believe our objective framework is a much-needed advancement.”
Researchers from the study gratefully acknowledge funding support from the Big Data to Knowledge (BD2K) Training Coordinating Center (TCC) through the Data Science Rotations for Advancing Discovery (RoAD-Trip) program (grant #1U24ES026465-03). This work was also partly supported by NIH grant #R01GM114434, an IBM faculty award, and grant #PC140371 from the Department of Defense Prostate Cancer Research Program.
About the Mount Sinai Health System
Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, over 400 outpatient practices, nearly 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it.
Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes approximately 7,300 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in 4 out of 10 pediatric specialties. The Icahn School of Medicine at Mount Sinai is one of three medical schools that have earned distinction by multiple indicators: It is consistently ranked in the top 20 by U.S. News & World Report's "Best Medical Schools," aligned with a U.S. News & World Report "Honor Roll" Hospital, and top 20 in the nation for National Institutes of Health funding and top 5 in the nation for numerous basic and clinical research areas. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.