Mount Sinai and USC Researchers Develop Prostate Cancer Prediction Tool That Has Unmatched Accuracy
Current tools used to predict prostate cancer progression are generally subjective in nature, leading to differing interpretations among clinicians
A team of researchers from the Icahn School of Medicine at Mount Sinai and Keck School of Medicine at the University of Southern California (USC) have developed a novel machine-learning framework that distinguishes between low- and high-risk prostate cancer with more precision than ever before. The framework, described in a Scientific Reports paper published today, is intended to help physicians—in particular, radiologists—more accurately identify treatment options for prostate cancer patients, lessening the chance of unnecessary clinical intervention.
Prostate cancer is one of the leading causes of cancer death in American men, second only to lung cancer. While recent advances in prostate cancer research have saved many lives, objective prediction tools have, until now, remained an unmet need.
Presently, the standard methods used to assess prostate cancer risk are multiparametric magnetic resonance imaging (mpMRI), which detects prostate lesions, and the Prostate Imaging Reporting and Data System, version 2 (PI-RADS v2), a five-point scoring system that classifies lesions found on the mpMRI. Together, these tools are intended to soundly predict the likelihood of clinically significant prostate cancer. However, PI-RADS v2 scoring is subjective and does not distinguish clearly between intermediate and malignant cancer levels (scores 3, 4, and 5), often leading to differing interpretations among clinicians.
Combining machine learning with radiomics—a branch of medicine that uses algorithms to extract large amounts of quantitative characteristics from medical images—has been proposed as an approach to remedy this drawback. However, other studies have only tested a limited number of machine learning methods to address this limitation. In contrast, the Mount Sinai and USC researchers developed a predictive framework that rigorously and systematically assessed many such methods to identify the best-performing one. The framework also leverages larger training and validation data sets than previous studies did. As a result, researchers were able to classify patients’ prostate cancer with high sensitivity and an even higher predictive value.
“By rigorously and systematically combining machine learning with radiomics, our goal is to provide radiologists and clinical personnel with a sound prediction tool that can eventually translate to more effective and personalized patient care,” said Gaurav Pandey, PhD, Assistant Professor of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai and senior corresponding author of the publication alongside co-corresponding author Bino Varghese, PhD, Assistant Professor of Research Radiology at the Keck School of Medicine at USC. “The pathway to predicting prostate cancer progression with high accuracy is ever improving, and we believe our objective framework is a much-needed advancement.”
Researchers from the study gratefully acknowledge funding support from the Big Data to Knowledge (BD2K) Training Coordinating Center (TCC) through the Data Science Rotations for Advancing Discovery (RoAD-Trip) program (grant #1U24ES026465-03). This work was also partly supported by NIH grant #R01GM114434, an IBM faculty award, and grant #PC140371 from the Department of Defense Prostate Cancer Research Program.
About the Mount Sinai Health System
The Mount Sinai Health System is New York City's largest academic medical system, encompassing eight hospitals, a leading medical school, and a vast network of ambulatory practices throughout the greater New York region. Mount Sinai is a national and international source of unrivaled education, translational research and discovery, and collaborative clinical leadership ensuring that we deliver the highest quality care—from prevention to treatment of the most serious and complex human diseases. The Health System includes more than 7,200 physicians and features a robust and continually expanding network of multispecialty services, including more than 400 ambulatory practice locations throughout the five boroughs of New York City, Westchester, and Long Island. The Mount Sinai Hospital is ranked No. 14 on U.S. News & World Report's "Honor Roll" of the Top 20 Best Hospitals in the country and the Icahn School of Medicine as one of the Top 20 Best Medical Schools in country. Mount Sinai Health System hospitals are consistently ranked regionally by specialty and our physicians in the top 1% of all physicians nationally by U.S. News & World Report.