Working Memory Is Positively Associated With Higher Physical Endurance and Better Cognitive Function, Mount Sinai Researchers Find
Suboptimal cardiovascular health, binge drinking, and smoking are associated with less cohesive brain network
Mount Sinai researchers have found a positive relationship between the brain network associated with working memory—the ability to store and process information relevant to the task at hand—and healthy traits such as higher physical endurance and better cognitive function.
These traits were associated with greater cohesiveness of the working memory brain network while traits indicating suboptimal cardiovascular and metabolic health, and suboptimal health habits including binge drinking and regular smoking, were associated with less cohesive working memory networks.
This is the first study to establish the link between working memory and physical health and lifestyle choices.
The results of the study will be published online in Molecular Psychiatry on Tuesday, December 5, at 4 am EST.
The research team took brain scans of 823 participants in the Human Connectome Project (HCP), a large brain imaging study funded by the National Institutes of Health, while they performed a task involving working memory, and extracted measures of brain activity and connectivity to create a brain map of working memory. The team then used a statistical method called sparse canonical correlation to discover the relationships between the working memory brain map and 116 measures of cognitive ability, physical and mental health, personality, and lifestyle choices. They found that cohesiveness in the working memory brain map was positively associated with higher physical endurance and better cognitive function. Physical traits such as high body mass index, and suboptimal lifestyle choices including binge alcohol drinking and regular smoking, had the opposite association.
“Working memory accounts for individual differences in personal, educational, and professional attainment,” said Sophia Frangou, MD, PhD, Professor of Psychiatry at the Icahn School of Medicine at Mount Sinai. “Working memory is also one of the brain functions that is severely affected by physical and mental illnesses. Our study identified factors that can either support or undermine the working memory brain network. Our findings can empower people to make informed choices about how best to promote and preserve brain health.”
This study was supported by grants from the National Institutes of Health (R01 MH104284-01A1) and European Unit FP7 program (IMAGEMEND 602450; IMAging GEnetics for MENtal Disorders) projects, the Swiss National Science Foundation, the National Institute for HealthResearch (NIHR; Biomedical Research Centre at South London and Maudsley NHSFoundation Trust and King’s College London) and the Bundesministerium für Bildung und Forschung (eMED SysAlc01ZX1311A).HCP data are disseminated by the Laboratory of Neuro Imaging at the University of Southern California.
About the Mount Sinai Health System
The Mount Sinai Health System is New York City's largest academic medical system, encompassing eight hospitals, a leading medical school, and a vast network of ambulatory practices throughout the greater New York region. Mount Sinai advances medicine and health through unrivaled education and translational research and discovery to deliver care that is the safest, highest-quality, most accessible and equitable, and the best value of any health system in the nation. The Health System includes approximately 7,300 primary and specialty care physicians; 13 joint-venture ambulatory surgery centers; more than 415 ambulatory practices throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. The Mount Sinai Hospital is ranked on U.S. News & World Report's "Honor Roll" of the top 20 U.S. hospitals and is top in the nation by specialty: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. Mount Sinai Kravis Children's Hospital is ranked in U.S. News & World Report’s “Best Children’s Hospitals” among the country’s best in four out of 10 pediatric specialties. The Icahn School of Medicine is one of three medical schools that have earned distinction by multiple indicators: ranked in the top 20 by U.S. News & World Report's "Best Medical Schools," aligned with a U.S. News & World Report "Honor Roll" Hospital, and No. 14 in the nation for National Institutes of Health funding. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.