What Are Medical Researchers Working On to Improve Health Care and Prolong Lives? The Frontiers of Medical Research: A Supplement From Science Magazine and the Icahn School of Medicine at Mount Sinai
To read the supplement: https://www.science.org/content/resource/frontiers-medical-research
A newly published supplement to Science magazine—developed in partnership with the Icahn School of Medicine at Mount Sinai (Icahn Mount Sinai) —explores “The Frontiers of Medical Research.” The supplement includes 17 concise survey articles prepared by teams of researchers at Icahn Mount Sinai on the most important and promising breakthroughs and directions for medical research.
The articles summarize what’s new and what’s next across many fields of specialization, including artificial intelligence, cancer, cardiovascular medicine, genomics, immunology, and neuroscience. As Dennis S. Charney, Anne and Joel Ehrenkranz Dean of Icahn Mount Sinai, and Eric J. Nestler, Dean for Academic and Scientific Affairs, write in the foreword to the supplement, “We envision a world of medicine that is smarter, more equitable and inclusive, and more capable of healing and preventing disease.”
This special collection of articles provides a telescopic look at where the next generation of diagnostics and therapeutics will emerge as the transformation of medicine continues to protect, prolong, and improve lives. New developments that are reported in these articles—and that researchers are available to be interviewed about—include:
- Translating insights from genomic sequencing to novel gene therapies that treat infectious diseases and rare inherited disorders, as well as cancer;
- Employing multiscale science to understand the mechanisms that control immune responses and use them to therapeutically manage immunity and inflammation across diseases;
- Manufacturing microbiome cocktails that may improve patient outcomes in inflammatory diseases and during cancer immunotherapy;
- Employing synthetic mRNA to reprogram cells and even transform them into miniature drug-manufacturing sites;
- Editing genes to correct disease-associated mutations and exploring the possibility of manipulating transcriptional responses to noxious stimuli to minimize disease risk;
- Using satellites and other remote sensors that measure daily climate, air, and noise pollution to understand how such exposomic factors influence health;
- Delivering personalized medicine not only for cancer care, but also in specialties like obstetrics to predict intrapartum risks and guide care;
- Learning how individual brain cells interact within circuits and how circuits generate specific behaviors, essential steps towards gaining the capability to treat effectively brain disorders.
About the Mount Sinai Health System
Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, over 400 outpatient practices, nearly 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it.
Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes approximately 7,300 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties.