• Press Release

What Are Medical Researchers Working On to Improve Health Care and Prolong Lives? The Frontiers of Medical Research: A Supplement From Science Magazine and the Icahn School of Medicine at Mount Sinai

To read the supplement: https://www.science.org/content/resource/frontiers-medical-research

  • New York, NY
  • (November 22, 2021)

A newly published supplement to Science magazine—developed in partnership with the Icahn School of Medicine at Mount Sinai (Icahn Mount Sinai) —explores “The Frontiers of Medical Research.” The supplement includes 17 concise survey articles prepared by teams of researchers at Icahn Mount Sinai on the most important and promising breakthroughs and directions for medical research.

The articles summarize what’s new and what’s next across many fields of specialization, including artificial intelligence, cancer, cardiovascular medicine, genomics, immunology, and neuroscience. As Dennis S. Charney, Anne and Joel Ehrenkranz Dean of Icahn Mount Sinai, and Eric J. Nestler, Dean for Academic and Scientific Affairs, write in the foreword to the supplement, “We envision a world of medicine that is smarter, more equitable and inclusive, and more capable of healing and preventing disease.” 

This special collection of articles provides a telescopic look at where the next generation of diagnostics and therapeutics will emerge as the transformation of medicine continues to protect, prolong, and improve lives. New developments that are reported in these articles—and that researchers are available to be interviewed about—include:

  • Translating insights from genomic sequencing to novel gene therapies that treat infectious diseases and rare inherited disorders, as well as cancer;
  • Employing multiscale science to understand the mechanisms that control immune responses and use them to therapeutically manage immunity and inflammation across diseases;
  • Manufacturing microbiome cocktails that may improve patient outcomes in inflammatory diseases and during cancer immunotherapy;
  • Employing synthetic mRNA to reprogram cells and even transform them into miniature drug-manufacturing sites;
  • Editing genes to correct disease-associated mutations and exploring the possibility of manipulating transcriptional responses to noxious stimuli to minimize disease risk;
  • Using satellites and other remote sensors that measure daily climate, air, and noise pollution to understand how such exposomic factors influence health;
  • Delivering personalized medicine not only for cancer care, but also in specialties like obstetrics to predict intrapartum risks and guide care;
  • Learning how individual brain cells interact within circuits and how circuits generate specific behaviors, essential steps towards gaining the capability to treat effectively brain disorders.

About the Mount Sinai Health System

The Mount Sinai Health System is New York City's largest academic medical system, encompassing eight hospitals, a leading medical school, and a vast network of ambulatory practices throughout the greater New York region. Mount Sinai advances medicine and health through unrivaled education and translational research and discovery to deliver care that is the safest, highest-quality, most accessible and equitable, and the best value of any health system in the nation. The Health System includes approximately 7,300 primary and specialty care physicians; 13 joint-venture ambulatory surgery centers; more than 415 ambulatory practices throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. The Mount Sinai Hospital is ranked on U.S. News & World Report's "Honor Roll" of the top 20 U.S. hospitals and is top in the nation by specialty: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. Mount Sinai Kravis Children's Hospital is ranked in U.S. News & World Report’s “Best Children’s Hospitals” among the country’s best in four out of 10 pediatric specialties. The Icahn School of Medicine is one of three medical schools that have earned distinction by multiple indicators: ranked in the top 20 by U.S. News & World Report's "Best Medical Schools," aligned with a U.S. News & World Report "Honor Roll" Hospital, and No. 14 in the nation for National Institutes of Health funding. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

For more information, visit https://www.mountsinai.org or find Mount Sinai on FacebookTwitter and YouTube.