Human Immune Monitoring Center at Mount Sinai to Analyze the Effectiveness of a Novel Cancer Therapy Drug
The Human Immune Monitoring Center (HIMC) at the Icahn School of Medicine at Mount Sinai will apply cutting-edge high-throughput technologies to evaluate the therapeutic effects of Libtayo® (cemiplimab-rwlc), a PD-1 antibody blockade developed by biotechnology company Regeneron Pharmaceuticals, Inc and Sanofi.
While immunotherapy has revolutionized the field of oncology, there are still key questions that remain—such as learning more about how these drugs work in human cancer—and many patients still fail to respond to these therapies, leaving a need to better understand how FDA-approved immunotherapies work and how we can use emerging therapies to further improve response rates to treatment. In a phase I clinical trial led by Thomas Marron, MD, PhD, Assistant Director of Early Phase and Immunotherapy Trials at The Tisch Cancer Institute at Mount Sinai, the HIMC will assess the clinical efficacy and response of patients to cemiplimab therapy in early-stage non-small cell lung cancer (NSCLC), hepatocellular carcinoma (HCC), and head and neck squamous cell carcinoma (HNSCC). The HIMC will utilize optimized techniques to deeply interrogate the changes induced by these novel therapies within the tumor. These techniques include single cell mapping of cancer lesions and circulating immune cells, spatial mapping of the tumor tissues, and sequencing of the patient’s microbiome before and after treatment.
Led by Miriam Merad, MD, PhD, Director of the Precision Immunology Institute and Co-Director of Cancer Immunology Program, The Tisch Cancer Institute of the Icahn School of Medicine at Mount Sinai, the HIMC leverages new proprietary technologies and platforms to characterize immune profiles and responses across a diverse range of disease settings.
“We are a team of highly integrated scientists with distinct expertise in medicine, immunology, technology, mathematics and physics, whose goals are to dissect the contribution of the immune system to human diseases and use this knowledge to design novel immune-based therapies,” said Merad.
The HIMC currently supports over 45 federal and foundation-funded research programs across a diverse range of diseases including cancer, autoimmune disease, inflammatory bowel disease, allergy and neurodegenerative disease. It also serves as a central resource for several multi-institutional consortia including the NIH Human Immunology Project Consortium (HIPC), the Children’s Health Exposure Analysis Resource (CHEAR) and the Consortium of Food Allergy Research (CoFAR). The HIMC is also one of four NCI-designated Cancer Immune Monitoring and Analysis Center and is actively supporting 13 industry-sponsored research programs.
“The large body of expertise in immuno-oncology, as well as the foundational and innovative approach found within the HIMC and Dr. Merad’s team, strongly influenced our decision to work with Mount Sinai on this study,” said Gavin Thurston, Vice President of Oncology and Angiogenesis at Regeneron.
“The breadth and number of partnerships between the HIMC and leading academic and industry partners reflects the quality of cutting-edge, proprietary techniques and technologies developed by Dr. Merad and her team,” said Erik Lium, PhD, Executive Vice President of Mount Sinai Innovation Partners, the commercialization engine of the Mount Sinai Health System. “We look forward to expanding the HIMC and to broadly engaging with additional academic life science, biotech and pharma partners on transformative, groundbreaking research.”
About Mount Sinai Innovation Partners (MSIP)
Mount Sinai Innovation Partners (MSIP) is responsible for driving the real-world application and commercialization of Mount Sinai discoveries and inventions, and the development of research partnerships with industry. Our aim is to translate discoveries and inventions into health care products and services that benefit patients and society. MSIP is accountable for the full spectrum of commercialization activities required to bring Mount Sinai inventions to life. These activities include evaluating, patenting, marketing and licensing new technologies building research, collaborations and partnerships with commercial and nonprofit entities, material transfer and confidentiality, coaching innovators to advance commercially-relevant translational discoveries, and actively fostering an ecosystem of entrepreneurship within the Mount Sinai research and health system communities. For more information, please visit www.ip.mountsinai.org.
About the Mount Sinai Health System
The Mount Sinai Health System is New York City's largest academic medical system, encompassing eight hospitals, a leading medical school, and a vast network of ambulatory practices throughout the greater New York region. Mount Sinai is a national and international source of unrivaled education, translational research and discovery, and collaborative clinical leadership ensuring that we deliver the highest quality care—from prevention to treatment of the most serious and complex human diseases. The Health System includes more than 7,200 physicians and features a robust and continually expanding network of multispecialty services, including more than 400 ambulatory practice locations throughout the five boroughs of New York City, Westchester, and Long Island. The Mount Sinai Hospital is ranked No. 14 on U.S. News & World Report's "Honor Roll" of the Top 20 Best Hospitals in the country and the Icahn School of Medicine as one of the Top 20 Best Medical Schools in country. Mount Sinai Health System hospitals are consistently ranked regionally by specialty and our physicians in the top 1% of all physicians nationally by U.S. News & World Report.