"Mount Sinai Researchers First to Discover Single Cell Immune Composition of Plaques From Stroke Patients"
Atherosclerotic plaque, the fatty buildup in arteries that can lead to heart attack and stroke, contains an abundance of the immune cells known as T-cells, Mount Sinai researchers have shown for the first time. “This is a first study towards the ultimate goal of building a single-cell immune atlas of human atherosclerosis. By profiling individual cells in blood and atherosclerotic plaques, we found new inflammatory alterations in plaques related to cardiovascular events,” said lead investigator Chiara Giannarelli, MD, PhD, assistant professor of medicine, cardiology, and genetics and genomic Sciences, at the Icahn School of Medicine at Mount Sinai. “This study is a perfect example of how single-cell mapping of human disease lesions can transform our understanding of disease pathophysiology,” said co-author Miriam Merad, MD, PhD, director of the Precision Immunology Institute, and director of the Human Immune Monitoring Center at the Icahn School of Medicine at Mount Sinai.
— Chiara Giannarelli, MD, PhD, Assistant Professor, Medicine, Cardiology, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
— Miriam Merad, MD, PhD, Professor, Medicine, Hematology and Medical Oncology, Oncological Sciences, Director, Precision Immunology Institute, Director, Mount Sinai Human Immune Monitoring Center, Co-Director, Cancer Immunology Program, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
— J Mocco, MD, MS, Professor, Neurosurgery, Vice Chair, Department of Neurosurgery, Director, Cerebrovascular Center, Mount Sinai Health System
— Peter Faries, MD, Professor, Surgery, Radiology, Icahn School of Medicine at Mount Sinai, Chief, Vascular Surgery, Mount Sinai Health System