Medical Xpress - Dr. Giulio Maria Pasinetti: “Biosynthetic Grape-Derived Compound Prevents Progression Of Alzheimer's Disease In Mice”
Polyphenols, which occur naturally in grapes, fruits, and vegetables, have been shown to prevent the cognitive decline associated with AD in a mouse model, but the molecules are very complex and are extensively metabolized in the body. Mount Sinai performed the first study to determine which specific subfraction of these molecules penetrates the animal brain, and demonstrating that a drug compound similar to polyphenols can exert similar bioactivities. "While this is an exciting development, we have a lot to discover and many years of testing before this agent can be considered in humans," said Dr. Giulio Maria Pasinetti, MD, PhD, Professor and Chair in Neurology at Mount Sinai School of Medicine. "I look forward to further studying this compound to determine its feasibility as a treatment for Alzheimer's disease." Learn more
About the Mount Sinai Health System
Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with 48,000 employees working across seven hospitals, more than 400 outpatient practices, more than 600 research and clinical labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time—discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it.
Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes approximately 9,000 primary and specialty care physicians and 10 free-standing joint-venture centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida. Hospitals within the System are consistently ranked by Newsweek’s® “The World’s Best Smart Hospitals, Best in State Hospitals, World Best Hospitals and Best Specialty Hospitals” and by U.S. News & World Report's® “Best Hospitals” and “Best Children’s Hospitals.” The Mount Sinai Hospital is on the U.S. News & World Report® “Best Hospitals” Honor Roll for 2025-2026.
For more information, visit https://www.mountsinai.org or find Mount Sinai on Facebook, Instagram, LinkedIn, X, and YouTube.
Immune Cells Identified as Key Players in Brain Health
Mar 21, 2024 View All Press Releases
AI Finds Key Signs That Predict Patient Survival Across Dementia Types
Feb 28, 2024 View All Press Releases