New Mount Sinai Study Shows Exposure to Certain Pesticides Impacts Child Cognitive Development
Prenatal exposure to a group of pesticides called organophosphates negatively impacted perceptual reasoning, a measure of nonverbal problem-solving skills.
Researchers at Mount Sinai School of Medicine have found that exposure during pregnancy to a family of pesticides called organophosphates may impair child cognitive development. The findings are published online in Environmental Health Perspectives.
From 1998 to 2002, the Mount Sinai Children’s Environmental Health Study enrolled a multiethnic population of more than 400 women in their third trimester of pregnancy. The research team collected urine samples during pregnancy and analyzed them for the evidence of metabolized pesticides. The women were then invited to participate in follow-up interviews when their children were ages 12 months, 24 months, and six to nine years.
At 12 and 24 months the children were assessed using the Bayley Scales of Infant development, which is a standardized instrument that measures cognitive and psychomotor development in young children. Between the ages of six and nine years, the researchers administered skill and intelligence tests. The researchers found that exposure to organophosphates negatively impacted perceptual reasoning, a measure of nonverbal problem-solving skills.
"Manufacturers withdrew chlorpyrifos and diazinon, two types of organophosphate pesticides, from the residential market. Despite this, general population exposure to organophosphate pesticides is ongoing," said Stephanie Engel, PhD, who led the study while on faculty at Mount Sinai School of Medicine.
"We have previously reported that prenatal exposure to these pesticides was negatively related to measures of neurobehavioral organization and early markers of central nervous system development in newborns. These new findings show that detrimental effects continue to be seen on cognitive development in early childhood, particularly in subgroups of the population that metabolize these compounds less efficiently," Dr. Engel said.
Dr. Engel’s team also examined the influence of variants in a key enzyme that metabolizes organophosphates, paraoxonase 1 (PON1). They found that the negative effects of organophosphates were limited to children of mothers who carried a genotype associated with a less efficient version of this enzyme.
"Nearly a third of the mothers in this study carried the PON1 genotype that would put their children at highest risk of negative effects from organophosphate pesticide exposure," said Dr. Engel, who is currently Associate Professor of Epidemiology at the Gillings School of Global Public Health at the University of North Carolina at Chapel Hill. "These highly susceptible individuals may account for the majority of exposure-related cognitive impairment. However, it’s not clear how the changing nature of general population exposure following the ban on residential use will impact our understanding of these effects. Exposure source may play an important role, and exposure through diet may now be the predominant source of exposure for the general population rather than indoor pest control."
Dr. Engel added, "Our study will be published along with two independent studies that examined prenatal organophosphate pesticide exposure in relation to childhood IQ using similar research methods. There are definite similarities in our findings that, taken as a whole, warrant careful consideration."
Other Mount Sinai study authors include Mary S. Wolff, PhD, Professor, Preventive Medicine and Oncological Sciences; James Wetmur, PhD, Professor Microbiology and Human Genetics, Jia Chen, ScD, Professor, Preventive Medicine, Pediatrics, and Oncological Sciences; and Chenbo Zhu, Senior Biostatistician, Preventive Medicine.
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The Mount Sinai Medical Center encompasses both The Mount Sinai Hospital and Mount Sinai School of Medicine. Established in 1968, Mount Sinai School of Medicine is one of few medical schools embedded in a hospital in the United States. It has more than 3,400 faculty in 32 departments and 15 institutes, and ranks among the top 20 medical schools both in National Institute of Health funding and by U.S. News & World Report. The school received the 2009 Spencer Foreman Award for Outstanding Community Service from the Association of American Medical Colleges.
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The Mount Sinai Health System is New York City's largest academic medical system, encompassing eight hospitals, a leading medical school, and a vast network of ambulatory practices throughout the greater New York region. Mount Sinai is a national and international source of unrivaled education, translational research and discovery, and collaborative clinical leadership ensuring that we deliver the highest quality care—from prevention to treatment of the most serious and complex human diseases. The Health System includes more than 7,200 physicians and features a robust and continually expanding network of multispecialty services, including more than 400 ambulatory practice locations throughout the five boroughs of New York City, Westchester, and Long Island. The Mount Sinai Hospital is ranked No. 14 on U.S. News & World Report's "Honor Roll" of the Top 20 Best Hospitals in the country and the Icahn School of Medicine as one of the Top 20 Best Medical Schools in country. Mount Sinai Health System hospitals are consistently ranked regionally by specialty and our physicians in the top 1% of all physicians nationally by U.S. News & World Report.