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"Ups and Downs of Exercise for Women's Bone Health" - Elizabeth Hlavinka

  • MedPage Today
  • New York, NY
  • (March 26, 2019)

Walking downhill on a treadmill within an hour after eating produced a large osteogenic response in postmenopausal women with diabetes -- an effect not seen with uphill walking, according to researchers at ENDO 2019, The Endocrine Society Meeting. In a randomized, partial-crossover trial, women who exercised downhill for 40 minutes had increased levels of C-terminal propeptide of type I collagen (a marker of bone formation) relative to no-exercise control and to walking uphill. Mone Zaidi, MD, PhD, and professor of medicine, endocrinology, diabetes and bone disease at the Icahn School of Medicine at Mount Sinai said, “Exercise could plausibly be one of many components contributing to bone fragility in women with diabetes, but that factors more related to the women's diabetes itself are more likely at play.” Dr. Zaidi added “For example, the longer a patient has diabetes, the more advanced glycation end products accumulate, he said, and the concentration of AGEs in diabetic patients are known to be associated with fracture risk. This would need to be measured and controlled for in order for Borer's results to be interpreted with confidence.”

—  Mone Zaidi, MD, PhD, Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Pharmacological Sciences, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, Director, Mount Sinai Bone Program

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