Mone Zaidi
- PROFESSOR Medicine, Endocrinology, Diabetes and Bone Disease
- PROFESSOR Geriatrics and Palliative Medicine
- PROFESSOR Structural and Chemical Biology
Print Profile
Specialty
Clinical Focus
- Dual Energy X-Ray Absorptiometry
- Hyperparathyroidism
- Osteogenesis Imperfecta
- Osteoporosis
- Paget's Disease of Bone
- Vitamin D Deficiency
Research Topics
Training Areas
Education
PHD, Royal Postgraduate Medical School
MBBS, King George's Medical College
MD, University of London
Residency, Medicine-Endoc
Royal Postgraduate Medical School
Awards
-
Research Excellence Award - Department of Veterans Affairs
NIH Orthopedics and Musculoskeletal Study Section-
Elected
Department of Veterans Affairs Endocrine Merit Review Committee-
Member
Association of Osteobiology, Interurban Clinical Club, Councilor-
Fellow
Royal College of Physicians-
Award
Sir Edmund Davis Scholarship2010 -
Honorary Doctor of Medicine (Laurea Honoris Causa),
University of Bari2010 -
Sreebny Distinguished Lecture,
State University of New York, Stony Brook,2009 -
The Marookian Lecture
University of Pennsylvania2008 -
Sibte H. Zaidi Memorial Oration
Indian Institute of Toxicology Research, India2008 -
Kramer Visiting Professor
Dartmouth Medical School2006 -
Hightlight Speaker
NIA Council2005 - 2006
Scientific Director and Chair
New York Skeletal Biology and Medicine Conferences Highlight Speaker, NIA Council2005 - 2006
Invited Speaker
Japanese Bone and Mineral society2004 -
Elected
Association of American Physicians2002 -
Eweson Lecturer
Cambridge Philosophical Society2001 -
National Scientific Advisory Council & Research Committee
American Federation for Aging Research2000 -
Elected
Department of Veterans Affairs Merit Review Council2000 -
Foster Lecture
University of Cambridge2000 -
Member
American Society for Clinical Investigation2000 - 2003
Elected
Department of Veterans Affairs Medical Research Advisory Group1998 -
Fellow
Royal College of Pathologists1995 -
Fellow
Institute of Biologists of England1995 -
Award
Tata Memorial Scholar, London1988 -
Lecturer
Nuffield Award for Science Lecturer, London1983 -
Award
Stott Gold Medal in Pathology
Research
Research
Mone Zaidi has made seminal contributions to the pathogenesis and therapy of osteoporosis, a devastating public health hazard. These include the first description of extracellular calcium sensing by the osteoclast; evidence that nuclear calcium in bone cells is tightly regulated by ryanodine receptors; and the discovery that nitric oxide controls osteoclast function. More recently, he established the concept of a pituitary-bone axis, in which the pituitary hormones FSH, TSH, ACTH and oxytocin directly regulate the skeleton. The idea that low TSH contributes to the osteoporosis of thyroid disorders has led to revised criteria that mandate less aggressive TSH suppression. Similarly, the rapid late peri-menopausal bone loss, which is now partly attributable to a rising FSH, has prompted new guidelines for early evaluation of women. The finding that ACTH attenuates avascular necrosis of the hip will likewise help prevent this crippling complication of long-term steroid use. Finally, Dr. Zaidi has proven that the inhibition of calcineurin in the osteoblast by the widely used immunosuppressant drugs cyclosporine and tacrolimus underlies the acute, rapid, and severe bone loss in transplant patients. These observations have thus created new paradigms for understanding and treating osteoporosis. Importantly, Dr. Zaidi has chaired several standing study sections, and has conceptualized and runs one of the most revered international conferences in skeletal biology and medicine.
Publications
Zaidi M, Sun L, Robinson LJ, Tourkova IL, Liu L, Wang Y, Zhu LL, Liu X, Liu JH, Peng YZ, Yang G, Sun H, Levine A, Iqbal J, Yaroslavskiy BB, Isales C, Blair HC, . ACTH protects against glucocorticoid-induced osteonecrosis of bone. Proceedings of the National Academy of Science 2010;(107): 8782-8787.
Iqbal J, Sun L, Zaidi M. Coupling bone degradation and formation.. Nature Medicine 2009;(15): 729-731.
Tamma R, Colaianni G, Zhu LL, DiBenedetto A, Greco G, Montemurro G, Patano N, Strippoli M, Vergari R, Mancini L, Colucci S, Grano MM, Faccio R, Liu X, Li J, Usmani S, Nishimori K, Young L, Bachar M, Bab I, Buettner C, Iqbal J, Sun L, Zaidi M, Zallone A. Oxytocin is an anabolic bone hormone.. Proceeding of the national Academy of Science 2008;(106): 7149-7154.
Sun L, Vukicevic S, Baliram A, Yang G, Sendak R, McPherson J, Zhu LL, Iqbal J, Latif R, Natrajan A, Arabi A, Yamoah KO, Moonga BS, Gabet Y, Davies TF, Bab I, Abe E, Sampath K, Zaidi M, , . Intermittent recombinant TSH injection prevents ovariectomy-induced bone loss.. Proceedings of the national Academy of Sciences 2008;(105): 4289-4294.
Zaidi M. Skeletal remodeling in health and disease. Nature Medicine 2007;(13): 791-801.
Iqbal J, Sun L, Kumar TR, Blair HC, Zaidi M. FSH stimulates TNF production from immune cells to trigger osteoclast and osteoblast formation.. Proceedings of the National Academy of Sciences;(103): 14925-14930.
Hase H, Ando T, Eldeiry L, Brebene A, Peng Y, Lin L, Amano H, Davies TF, Sun L, Zaidi M, Abe E. TNF mediates the skeletal effects of TSH. Proceedings of the National Academy of Sciences;(103): 12849-12854.
Sun L, Zhang Z, Iqbal J, Zaidi S, Papachristou DJ, Zhou H, Sharrow AC, Peng Y, Yaroslavskiy BB, Zhu LL, Zallone A, Sairam MR, Kumar TR, Landa LC, Schaffler MB, Moonga BS, Blair HC, Zaidi M. FSH directly regulates bone mass.. Cell 2006;(125): 247-260.
Sun L, Blair HC, Peng Y, Zaidi N, Adebanjo OA, Wu XB, Wu XY, Iqbal J, Epstein S, Abe E, Moonga BS, Zaidi M. Calcineurin regulates bone formation by the osteoblast.. Proceedings of the National Academy of Sciences 2005;(47): 17130-17135.
Abe E, Marians R, Wu XB, Iqbal J, Ando T, Blair HC, Davies TF, Zaidi M. TSH is a negative regulator of bone remodelling.. Cell;(175): 151-162.
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Zaidi during 2012 and/or 2013. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Consulting:
- Gerson Lehrman Group; GlaxoSmithKline; Merck & Co., Inc.
Industry-Sponsored Lectures: MSSM faculty occasionally give lectures at events sponsored by industry, but only if the events are free of any marketing purpose.
- Amgen Inc.; Nycomed ( Takeda Pharmaceuticals International GmbH); Teijin Limited
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.
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- 1199 Member Choice
- Aetna POS
- Aetna PPO
- Aetna U.S. Healthcare - HMO
- Devon Health Services
- HealthNet
- Medicaid
- Medicare
- Oxford Freedom
- Oxford Liberty
- Touchstone
- United Health Care - Mount Sinai Top Tier
- United Health Care Commercial
- United Health Care Empire Plan