Mone Zaidi, MD, PhD Email Mone Zaidi

2010
Sreebny Distinguished Lecture,
State University of New York, Stony Brook,

2010
Honorary Doctor of Medicine (Laurea Honoris Causa),
University of Bari

2009
The Marookian Lecture
University of Pennsylvania

2008
Sibte H. Zaidi Memorial Oration
Indian Institute of Toxicology Research, India

2008
Kramer Visiting Professor
Dartmouth Medical School

2006
Hightlight Speaker
NIA Council

2005
Invited Speaker
Japanese Bone and Mineral society
Japan Bone Forum

2005
Scientific Director and Chair
New York Skeletal Biology and Medicine Conferences Highlight Speaker, NIA Council

2004
Elected
Association of American Physicians

2002
Eweson Lecturer
Cambridge Philosophical Society
Co-Chair, Orgainzing Committee

2001
National Scientific Advisory Council & Research Committee
American Federation for Aging Research

2000
Elected
Department of Veterans Affairs Medical Research Advisory Group

2000
Member
American Society for Clinical Investigation

2000
Foster Lecture
University of Cambridge

2000
Elected
Department of Veterans Affairs Merit Review Council

1998
Fellow
Royal College of Pathologists

1995
Award
Tata Memorial Scholar, London

1995
Fellow
Institute of Biologists of England

1988
Lecturer
Nuffield Award for Science Lecturer, London

1983
Award
Stott Gold Medal in Pathology
King George's Medical College, Lucknow, India

Fellow
Royal College of Physicians
Dubin 1994, London 1997

Award
Sir Edmund Davis Scholarship
University of London

Elected
Department of Veterans Affairs Endocrine Merit Review Committee
Chair 2000, 2003-2006, Member 1997-2000

Member
Association of Osteobiology, Interurban Clinical Club, Councilor
2004, 2005, & 2010

Research Excellence Award - Department of Veterans Affairs
NIH Orthopedics and Musculoskeletal Study Section
Chair 2002-2003, Member 1998-2003

Research

Mone Zaidi has made seminal contributions to the pathogenesis and therapy of osteoporosis, a devastating public health hazard.  These include the first description of extracellular calcium sensing by the osteoclast; evidence that nuclear calcium in bone cells is tightly regulated by ryanodine receptors; and the discovery that nitric oxide controls osteoclast function.  More recently, he established the concept of a pituitary-bone axis, in which the pituitary hormones FSH, TSH, ACTH and oxytocin directly regulate the skeleton.  The idea that low TSH contributes to the osteoporosis of thyroid disorders has led to revised criteria that mandate less aggressive TSH suppression.  Similarly, the rapid late peri-menopausal bone loss, which is now partly attributable to a rising FSH, has prompted new guidelines for early evaluation of women.  The finding that ACTH attenuates avascular necrosis of the hip will likewise help prevent this crippling complication of long-term steroid use.  Finally, Dr. Zaidi has proven that the inhibition of calcineurin in the osteoblast by the widely used immunosuppressant drugs cyclosporine and tacrolimus underlies the acute, rapid, and severe bone loss in transplant patients.  These observations have thus created new paradigms for understanding and treating osteoporosis.  Importantly, Dr. Zaidi has chaired several standing study sections, and has conceptualized and runs one of the most revered international conferences in skeletal biology and medicine.

Zaidi M, Sun L, Robinson LJ, Tourkova IL, Liu L, Wang Y, Zhu LL, Liu X, Liu JH, Peng YZ, Yang G, Sun H, Levine A, Iqbal J, Yaroslavskiy BB, Isales C, Blair HC, . ACTH protects against glucocorticoid-induced osteonecrosis of bone. Proceedings of the National Academy of Science 2010;(107): 8782-8787.

Iqbal J, Sun L, Zaidi M. Coupling bone degradation and formation.. Nature Medicine 2009;(15): 729-731.

Tamma R, Colaianni G, Zhu LL, DiBenedetto A, Greco G, Montemurro G, Patano N, Strippoli M, Vergari R, Mancini L, Colucci S, Grano MM, Faccio R, Liu X, Li J, Usmani S, Nishimori K, Young L, Bachar M, Bab I, Buettner C, Iqbal J, Sun L, Zaidi M, Zallone A. Oxytocin is an anabolic bone hormone.. Proceeding of the national Academy of Science 2008;(106): 7149-7154.

Sun L, Vukicevic S, Baliram A, Yang G, Sendak R, McPherson J, Zhu LL, Iqbal J, Latif R, Natrajan A, Arabi A, Yamoah KO, Moonga BS, Gabet Y, Davies TF, Bab I, Abe E, Sampath K, Zaidi M, , . Intermittent recombinant TSH injection prevents ovariectomy-induced bone loss.. Proceedings of the national Academy of Sciences 2008;(105): 4289-4294.

Zaidi M. Skeletal remodeling in health and disease. Nature Medicine 2007;(13): 791-801.

Iqbal J, Sun L, Kumar TR, Blair HC, Zaidi M. FSH stimulates TNF production from immune cells to trigger osteoclast and osteoblast formation.. Proceedings of the National Academy of Sciences;(103): 14925-14930.

Hase H, Ando T, Eldeiry L, Brebene A, Peng Y, Lin L, Amano H, Davies TF, Sun L, Zaidi M, Abe E. TNF mediates the skeletal effects of TSH. Proceedings of the National Academy of Sciences;(103): 12849-12854.

Sun L, Zhang Z, Iqbal J, Zaidi S, Papachristou DJ, Zhou H, Sharrow AC, Peng Y, Yaroslavskiy BB, Zhu LL, Zallone A, Sairam MR, Kumar TR, Landa LC, Schaffler MB, Moonga BS, Blair HC, Zaidi M. FSH directly regulates bone mass.. Cell 2006;(125): 247-260.

Sun L, Blair HC, Peng Y, Zaidi N, Adebanjo OA, Wu XB, Wu XY, Iqbal J, Epstein S, Abe E, Moonga BS, Zaidi M. Calcineurin regulates bone formation by the osteoblast.. Proceedings of the National Academy of Sciences 2005;(47): 17130-17135.

Abe E, Marians R, Wu XB, Iqbal J, Ando T, Blair HC, Davies TF, Zaidi M. TSH is a negative regulator of bone remodelling.. Cell;(175): 151-162.