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Mone Zaidi

  • PROFESSOR Medicine, Endocrinology, Diabetes and Bone Disease
  • PROFESSOR Structural and Chemical Biology
  • PROFESSOR Geriatrics and Palliative Medicine
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Specialty

Clinical Focus

Research Topics

Training Areas

Education

  • PHD, Royal Postgraduate Medical School

  • MBBS, King George's Medical College

  • Residency, Medicine-Endoc
    Royal Postgraduate Medical School

Awards

  • -
    Elected
    Department of Veterans Affairs Endocrine Merit Review Committee

  • -
    Member
    Association of Osteobiology, Interurban Clinical Club, Councilor

  • -
    Award
    Sir Edmund Davis Scholarship

  • -
    Fellow
    Royal College of Physicians

  • -
    Research Excellence Award - Department of Veterans Affairs
    NIH Orthopedics and Musculoskeletal Study Section

  • 2010 -
    Sreebny Distinguished Lecture,
    State University of New York, Stony Brook,

  • 2010 -
    Honorary Doctor of Medicine (Laurea Honoris Causa),
    University of Bari

  • 2009 -
    The Marookian Lecture
    University of Pennsylvania

  • 2008 -
    Sibte H. Zaidi Memorial Oration
    Indian Institute of Toxicology Research, India

  • 2008 -
    Kramer Visiting Professor
    Dartmouth Medical School

  • 2006 -
    Hightlight Speaker
    NIA Council

  • 2005 - 2006
    Invited Speaker
    Japanese Bone and Mineral society

  • 2005 - 2006
    Scientific Director and Chair
    New York Skeletal Biology and Medicine Conferences Highlight Speaker, NIA Council

  • 2004 -
    Elected
    Association of American Physicians

  • 2002 -
    Eweson Lecturer
    Cambridge Philosophical Society

  • 2001 -
    National Scientific Advisory Council & Research Committee
    American Federation for Aging Research

  • 2000 - 2003
    Elected
    Department of Veterans Affairs Medical Research Advisory Group

  • 2000 -
    Foster Lecture
    University of Cambridge

  • 2000 -
    Member
    American Society for Clinical Investigation

  • 2000 -
    Elected
    Department of Veterans Affairs Merit Review Council

  • 1998 -
    Fellow
    Royal College of Pathologists

  • 1995 -
    Award
    Tata Memorial Scholar, London

  • 1995 -
    Fellow
    Institute of Biologists of England

  • 1988 -
    Lecturer
    Nuffield Award for Science Lecturer, London

  • 1983 -
    Award
    Stott Gold Medal in Pathology

Research

Research

Mone Zaidi has made seminal contributions to the pathogenesis and therapy of osteoporosis, a devastating public health hazard.  These include the first description of extracellular calcium sensing by the osteoclast; evidence that nuclear calcium in bone cells is tightly regulated by ryanodine receptors; and the discovery that nitric oxide controls osteoclast function.  More recently, he established the concept of a pituitary-bone axis, in which the pituitary hormones FSH, TSH, ACTH and oxytocin directly regulate the skeleton.  The idea that low TSH contributes to the osteoporosis of thyroid disorders has led to revised criteria that mandate less aggressive TSH suppression.  Similarly, the rapid late peri-menopausal bone loss, which is now partly attributable to a rising FSH, has prompted new guidelines for early evaluation of women.  The finding that ACTH attenuates avascular necrosis of the hip will likewise help prevent this crippling complication of long-term steroid use.  Finally, Dr. Zaidi has proven that the inhibition of calcineurin in the osteoblast by the widely used immunosuppressant drugs cyclosporine and tacrolimus underlies the acute, rapid, and severe bone loss in transplant patients.  These observations have thus created new paradigms for understanding and treating osteoporosis.  Importantly, Dr. Zaidi has chaired several standing study sections, and has conceptualized and runs one of the most revered international conferences in skeletal biology and medicine.

Publications

Zaidi M, Sun L, Robinson LJ, Tourkova IL, Liu L, Wang Y, Zhu LL, Liu X, Liu JH, Peng YZ, Yang G, Sun H, Levine A, Iqbal J, Yaroslavskiy BB, Isales C, Blair HC, . ACTH protects against glucocorticoid-induced osteonecrosis of bone. Proceedings of the National Academy of Science 2010;(107): 8782-8787.

Iqbal J, Sun L, Zaidi M. Coupling bone degradation and formation.. Nature Medicine 2009;(15): 729-731.

Tamma R, Colaianni G, Zhu LL, DiBenedetto A, Greco G, Montemurro G, Patano N, Strippoli M, Vergari R, Mancini L, Colucci S, Grano MM, Faccio R, Liu X, Li J, Usmani S, Nishimori K, Young L, Bachar M, Bab I, Buettner C, Iqbal J, Sun L, Zaidi M, Zallone A. Oxytocin is an anabolic bone hormone.. Proceeding of the national Academy of Science 2008;(106): 7149-7154.

Sun L, Vukicevic S, Baliram A, Yang G, Sendak R, McPherson J, Zhu LL, Iqbal J, Latif R, Natrajan A, Arabi A, Yamoah KO, Moonga BS, Gabet Y, Davies TF, Bab I, Abe E, Sampath K, Zaidi M, , . Intermittent recombinant TSH injection prevents ovariectomy-induced bone loss.. Proceedings of the national Academy of Sciences 2008;(105): 4289-4294.

Zaidi M. Skeletal remodeling in health and disease. Nature Medicine 2007;(13): 791-801.

Iqbal J, Sun L, Kumar TR, Blair HC, Zaidi M. FSH stimulates TNF production from immune cells to trigger osteoclast and osteoblast formation.. Proceedings of the National Academy of Sciences;(103): 14925-14930.

Hase H, Ando T, Eldeiry L, Brebene A, Peng Y, Lin L, Amano H, Davies TF, Sun L, Zaidi M, Abe E. TNF mediates the skeletal effects of TSH. Proceedings of the National Academy of Sciences;(103): 12849-12854.

Sun L, Zhang Z, Iqbal J, Zaidi S, Papachristou DJ, Zhou H, Sharrow AC, Peng Y, Yaroslavskiy BB, Zhu LL, Zallone A, Sairam MR, Kumar TR, Landa LC, Schaffler MB, Moonga BS, Blair HC, Zaidi M. FSH directly regulates bone mass.. Cell 2006;(125): 247-260.

Sun L, Blair HC, Peng Y, Zaidi N, Adebanjo OA, Wu XB, Wu XY, Iqbal J, Epstein S, Abe E, Moonga BS, Zaidi M. Calcineurin regulates bone formation by the osteoblast.. Proceedings of the National Academy of Sciences 2005;(47): 17130-17135.

Abe E, Marians R, Wu XB, Iqbal J, Ando T, Blair HC, Davies TF, Zaidi M. TSH is a negative regulator of bone remodelling.. Cell;(175): 151-162.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Below are financial relationships with industry reported by Dr. Zaidi during 2014 and/or 2015. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Consulting:

  • F. Hoffman-La Roche Ltd.; Genzyme Corporation; Gerson Lehrman Group; Merck & Co., Inc.

Industry-Sponsored Lectures: MSSM faculty occasionally give lectures at events sponsored by industry, but only if the events are free of any marketing purpose.

  • Takeda Pharmaceuticals International GmbH

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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