• Press Release

Mount Sinai Researchers Identify Six Genes Driving Peanut Allergy Reactions

Results Represent Important Step Forward for New Therapies and Treatments

  • New York, NY
  • (December 05, 2017)

Mount Sinai researchers have identified six genes that activate hundreds of other genes in children experiencing severe allergic reactions to peanuts.  This is the first study in human trials to identify genes driving acute peanut allergic reactions using a double-blind placebo-controlled approach with comprehensive sequencing of genes expressed before, during, and after they ingested peanut.

The study was also the first to study gene expression in children over the course of their allergic reactions, allowing each subject’s reaction to be compared to their own pre-reaction state, rather than to a control group without peanut allergies. This approach allowed the researchers to accurately detect gene expression changes resulting from the reactions.

The results of the study will be published online in Nature Communications on Tuesday, December 5.

The standard treatment for individuals with peanut allergy includes avoidance of peanuts and prompt care for the allergic reaction. Immunotherapy has demonstrated progress, but it is not effective for all individuals, carries adverse side effects, and has not been approved by the U.S. Food and Drug Administration.

“This study highlights genes and molecular processes that could be targets for new therapies to treat peanut-allergy reactions and could be important  to understanding how peanut allergy works overall,” said the study’s senior author, Supinda Bunyavanich, MD, MPH, Associate Professor, Pediatrics and Genetics and Genomic Sciences at the  Icahn School of Medicine at Mount Sinai. “We still don’t completely understand everything that happens in the body during peanut-allergy reactions. We can use these genes to direct our studies of peanut allergy and hopefully, predict how strongly someone with peanut allergy will react.”

The research team collected blood samples from 40 peanut-allergic children before, during, and after a randomized, double-blind, placebo-controlled oral food challenge. Subjects ingested incremental amounts of peanut at 20-minute intervals until an allergic reaction occurred or a cumulative dose of 1.044 grams of peanut was ingested. In a similar fashion on a different day, the same subjects ingested incremental doses of placebo oat powder; again, blood samples were drawn before, during, and after the challenge. The team then performed comprehensive RNA sequencing on the blood samples followed by computational data analyses to determine what genes and cells were activated and driving these allergic reactions.

 “Other studies have looked at genes expressed in people with food allergies and compared them to people who don’t have food allergies,” said Dr. Bunyavanich. “One of the strengths of our study is that we looked at genes expressed over time in children actively reacting to peanut and followed  that person throughout their reaction, which provided a detailed and comprehensive picture of what’s happening on the genetic and molecular level during a peanut-allergy reaction.”

One of the limitations of the study is that it only focused on peanut allergy. Dr. Bunyavanich and the research team plan to conduct future studies targeting other common allergens, such as milk and egg, to address if their findings may be relevant to other types of food allergy.
This study was supported by NIH grants K08AI093538, R01AI118833, U19AI066738, and U01AI066560) and The Mindich Child Health and Development Institute at Mount Sinai. The project was also supported by grant nos. UL1TR-000154 (National Jewish), UL1 TR-000067 (Mount Sinai), UL1 TR-000039 (Arkansas), UL1 TR-000083 (U North Carolina) and UL1 TR-000424 (Johns Hopkins) from the National Center for Research Resources (NCRR), a component of the National Institutes of Health.


About the Mount Sinai Health System

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, over 400 outpatient practices, nearly 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it.

Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes approximately 7,300 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in 4 out of 10 pediatric specialties. The Icahn School of Medicine at Mount Sinai is one of three medical schools that have earned distinction by multiple indicators: It is consistently ranked in the top 20 by U.S. News & World Report's "Best Medical Schools," aligned with a U.S. News & World Report "Honor Roll" Hospital, and top 20 in the nation for National Institutes of Health funding and top 5 in the nation for numerous basic and clinical research areas. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

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