Medical Xpress - Dr. Giulio Maria Pasinetti: “Biosynthetic Grape-Derived Compound Prevents Progression Of Alzheimer's Disease In Mice”

New York, NY
 – May 3, 2012 /Press Release/  –– 

Polyphenols, which occur naturally in grapes, fruits, and vegetables, have been shown to prevent the cognitive decline associated with AD in a mouse model, but the molecules are very complex and are extensively metabolized in the body. Mount Sinai performed the first study to determine which specific subfraction of these molecules penetrates the animal brain, and demonstrating that a drug compound similar to polyphenols can exert similar bioactivities. "While this is an exciting development, we have a lot to discover and many years of testing before this agent can be considered in humans," said Dr. Giulio Maria Pasinetti, MD, PhD, Professor and Chair in Neurology at Mount Sinai School of Medicine. "I look forward to further studying this compound to determine its feasibility as a treatment for Alzheimer's disease." Learn more