Publications

Mount Sinai hosts some of the most advanced addiction research in the country. Our scientists publish in some of the most prestigious journals. Here is a selected bibliography.

• Striatal Rgs4 regulates feeding and susceptibility to diet-induced obesity.
  Michaelides M, Miller ML, Egervari G, Primeaux SD, Gomez JL, Ellis RJ, Landry JA, Szutorisz H, Hoffman AF, Lupica CR, Loos RJF, Thanos PK, Bray GA, Neumaier JF, Zachariou V, Wang GJ, Volkow ND, Hurd YL.
  Mol Psychiatry. 2018 Jun 28. doi: 10.1038/s41380-018-0120-7. [Epub ahead of print]
  PMID: 29955167
• Molecular windows into the human brain for psychiatric disorders.
  Egervari G, Kozlenkov A, Dracheva S, Hurd YL. 
  Mol Psychiatry. 2018 Jun 28. doi: 10.1038/s41380-018-0125-2. [Epub ahead of print] Review.
  PMID: 29955163
• An atlas of chromatin accessibility in the adult human brain.
  Fullard JF, Hauberg ME, Bendl J, Egervari G, Cirnaru MD, Reach SM, Motl J, Ehrlich ME, Hurd YL, Roussos P.
  Genome Res. 2018 Jun 26. pii: gr.232488.117. doi: 10.1101/gr.232488.117. [Epub ahead of print]
• Brain Cell Type Specific Gene Expression and Co-expression Network Architectures.
  McKenzie AT, Wang M, Hauberg ME, Fullard JF, Kozlenkov A, Keenan A, Hurd YL, Dracheva S, Casaccia P, Roussos P, Zhang B.
  Sci Rep. 2018 Jun 11;8(1):8868. doi: 10.1038/s41598-018-27293-5.
  PMID: 29892006
• THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders.
  Guennewig B, Bitar M, Obiorah I, Hanks J, O'Brien EA, Kaczorowski DC, Hurd YL, Roussos P, Brennand KJ, Barry G.
  Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
  PMID: 29691375
• Cannabidiol, an Adjunct Player in the Antipsychosis Arsenal.
  Bassir Nia A, Hurd YL.
  Am J Psychiatry. 2018 Mar 1;175(3):197-198. doi: 10.1176/appi.ajp.2017.17121295. No abstract available.
  PMID:29490489
• A new dawn in cannabinoid neurobiology: The road from molecules to therapeutic discoveries.
  Cheer JF, Hurd YL.
  Neuropharmacology. 2017 Sep 15;124:1-2. doi: 10.1016/j.neuropharm.2017.07.004. Epub 2017 Jul 8. No abstract available.
  PMID:28694099
• Dopamine D2 Receptor Signaling in the Nucleus Accumbens Comprises a Metabolic-Cognitive Brain Interface Regulating Metabolic Components of Glucose Reinforcement.
  Michaelides M, Miller ML, DiNieri JA, Gomez JL, Schwartz E, Egervari G, Wang GJ, Mobbs CV, Volkow ND, Hurd YL.
  Neuropsychopharmacology. 2017 Nov;42(12):2365-2376. doi: 10.1038/npp.2017.112. Epub 2017 Jun 5.
  PMID:28580946
• Shaping vulnerability to addiction - the contribution of behavior, neural circuits and molecular mechanisms.
  Egervari G, Ciccocioppo R, Jentsch JD, Hurd YL.
  Neurosci Biobehav Rev. 2018 Feb;85:117-125. doi: 10.1016/j.neubiorev.2017.05.019. Epub 2017 May 29. Review.
  PMID:28571877
• DNA Methylation Profiling of Human Prefrontal Cortex Neurons in Heroin Users Shows Significant Difference between Genomic Contexts of Hyper- and Hypomethylation and a Younger Epigenetic Age.
  Kozlenkov A, Jaffe AE, Timashpolsky A, Apontes P, Rudchenko S, Barbu M, Byne W, Hurd YL, Horvath S, Dracheva S.
  Genes (Basel). 2017 May 30;8(6). pii: E152. doi: 10.3390/genes8060152.
  PMID: 28556790
• High times for cannabis: Epigenetic imprint and its legacy on brain and behavior.
  Szutorisz H, Hurd YL.
  Neurosci Biobehav Rev. 2018 Feb;85:93-101. doi: 10.1016/j.neubiorev.2017.05.011. Epub 2017 May 12. Review.
  PMID:28506926
• Considerations for the Development of a Substance-Related Care and Prevention Continuum Model
  Perlman DC and  Jordan AE.
• Circuit-wide Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulating Depression Susceptibility. Neuron. 2016 May 11. pii: S0896-6273(16)30074-5. doi: 10.1016/j.neuron.2016.04.015
  Bagot RC, Cates HM, Purushothaman I, Lorsch ZS, Walker DM, Wang J, Huang X, Schlüter OM Maze I, Peña CJ, Heller EA, Issler O, Wang M, Song WM, Stein JL, Liu X, Doyle MA, Scobie KN, Sun HS, Neve RL, Geschwind D, Dong Y, Shen L, Zhang B, Nestler EJ.
• Psychiatric comorbidity associated with synthetic cannabinoid use compared to cannabis
  Bassir Nia, A., et al.
• Running on Empty: Leptin Signaling in VTA Regulates Reward from Physical Activity. Cell Metabolism. 2015 Oct 6; 22(4):540-1.doi: 10.1016/j.cmet.2015.09.021
  Chen Z, Kenny PJ.
• High early life stress and aberrant amygdala activity: Risk factors for elevated neuropsychiatric symptoms in HIV+ adults. Brain Imaging and Behavior
  Clark US, Sweet LH, Morgello S, Philip NS, Cohen RA. (in press).
• KCNQ channel openers reverse depressive symptoms via an active resilience mechanism
  Friedman AK, Juarez B, Ku SM, Zhang H, Calizo RC, Walsh JJ, Chaudhury D, Zhang S, Hawkins A, Dietz DM, Murrough JW, Ribadeneira M, Wong EH, Neve RL, Han MH.
• Basal forebrain projections to the lateral habenula modulate aggression reward. Nature. 2016 Jun 29;534(7609):688-92. doi: 10.1038/nature18601
  Golden SA, Heshmati M, Flanigan M, Christoffel DJ, Guise K, Pfau ML, Aleyasin H, Menard C, Zhang H, Hodes GE, Bregman D, Khibnik L, Tai J, Rebusi N, Krawitz B, Chaudhury D, Walsh JJ, Han MH, Shapiro ML, Russo SJ.