"Trans Women May Require Higher Doses of Estrogens" - Marie Benz
The standard trans feminizing hormone regimen includes estrogen both to suppress testosterone and so that the individual has sufficient circulating sex hormone in the body for good bone health. Joshua Safer, MD, executive director of the Center for Transgender Medicine and Surgery at Mount Sinai and senior faculty of medicine, endocrinology, diabetes and bone disease at the Icahn School of Medicine at Mount Sinai, said "Trans women may require higher doses of estrogens than previously suspected. Indeed cis women might benefit from more estrogen also." He concluded that while the observation is provocative, it is hardly conclusive. Future studies will need to ascertain both risk and actual benefit from the higher doses, Dr. Safer presented in an abstract at ENDO 2019, The Endocrine Society annual meeting.
— Joshua Safer, MD, Executive Director, Center for Transgender Medicine and Surgery at Mount Sinai, Senior Faculty, Medicine, Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai