"Increased Levels Of Human Herpesvirus Identified in Alzheimer’s"
Benjamin Readhead, MBBS, biomedical informatics research scientist at the Icahn Institute for Multiscale Biology at the Icahn School of Medicine at Mount Sinai, and colleagues constructed multiscale networks of late-onset Alzheimer’s disease-associated virome, integrating genomic, transcriptomic, proteomic, and histopathological data across four brain regions using tissue from human postmortem samples. "This study represents a significant advancement in our understanding of the plausibility of the pathogen hypothesis of Alzheimer's," a coauthor said in a statement. "If it becomes evident that specific viral species directly contribute to an individual's risk of developing Alzheimer's or their rate of progression once diagnosed, then this would offer a new conceptual framework for understanding the emergence and evolution of Alzheimer's at individual, as well as population, levels."
- Benjamin P. Readhead, MBBS, Biomedical Informatics Research Scientist, Icahn Institute for Multiscale Biology, Institute for Next Generation Healthcare, Icahn School of Medicine at Mount Sinai
- Joel Dudley, PhD, Director, Next Generation Healthcare Institute, Associate Professor, Genetics and Genomic Sciences, Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, Executive Vice President, Precision Health, Mount Sinai Health System
- Samuel Gandy, MD, PhD, Professor, Neurology, Psychiatry, Associate Director, Alzheimer’s Disease Research Center, Icahn School of Medicine at Mount Sinai, Director, The Mount Sinai Center for Cognitive Health and NFL Neurological Care