Helen S. Mayberg, MD, Appointed Director of Newly Established Center for Advanced Circuit Therapeutics for the Icahn School of Medicine at Mount Sinai
Helen S. Mayberg, MD, a neurologist renowned for her study of brain circuits in depression and for her pioneering deep brain stimulation research, which has been heralded as one of the first hypothesis-driven treatment strategies for a major mental illness, has joined the Mount Sinai Health System as the founding Director of The Center for Advanced Circuit Therapeutics. The new center will advance precision surgical treatments for neuropsychiatric disorders through the rapid conversion of neuroscience and neuroengineering innovations that correct brain circuit abnormalities to restore mood as well as motor and cognitive functioning.
As a behavioral neurologist, Dr. Mayberg has established an international reputation for her pioneering research to map the brain circuits implicated in depression. Early in her career, she developed one of the first “network” models for mood disorders—incorporating fundamentals of neuroanatomy and brain connections with imaging technologies—to propose an alternative neurological view of this classical psychiatric condition that extended beyond the neurochemical models that had dominated for decades. This circuit approach has evolved over the years and continues to anchor many contemporary studies of mood disorders, including the development and latest refinements of deep brain stimulation, a procedure for treatment-resistant depression that involves placing electrodes deep in the brain and turning them on at an amplitude and frequency that disrupts the activity between various brain regions.
“Dr. Mayberg brings to Mount Sinai a research history distinguished by a translational and interdisciplinary focus that integrates imaging with clinical and surgical studies,” says Eric J. Nestler, MD, PhD, Nash Family Professor of Neuroscience, Director of The Friedman Brain Institute, and Dean for Academic and Scientific Affairs at the Icahn School of Medicine at Mount Sinai. “Her research team will help Mount Sinai play a leading role globally in devising new and transformational treatments for depression and other neuropsychiatric disorders.”
Using positron emission topography (PET) scans and later, functional magnetic resonance imaging (MRI), combined with keen neuropsychiatric evaluation, Dr. Mayberg identified Brodmann area 25 (BA25), a brain area strategically positioned to impact the frontal lobes as well as deep regions in the amygdala, hippocampus, basal ganglia, and brainstem, which together regulate emotion, motivation, memory, self-reflection, sleep, and other basic drives, all of which can be disrupted in depressed patients. She found that the wiring of BA25 to these other regions proved critical to understanding the normal interactions of emotions and thought. Subsequent pivotal studies demonstrated that when BA25 was activated by intense sadness, higher centers in the frontal cortex shut down; similarly, when depression was treated, BA25 activity was reduced and frontal regions returned to normal functioning. While at the University of Toronto in the early 2000s, Dr. Mayberg led a research team that tested the first use of deep brain stimulation of BA25 in patients who had become unresponsive to all available antidepressant treatments. The surgical technique uses activation of electrodes placed in the brain to adjust and correct the abnormal communication between BA25 and other regions of the brain.
“Dr. Mayberg is a spectacular recruit to the Mount Sinai Health System,” says Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean of the Icahn School of Medicine at Mount Sinai and President for Academic Affairs for the Mount Sinai Health System. “Our culture is rooted in innovation and a passion for pushing the boundaries of knowledge. Under Dr. Mayberg’s leadership, The Center for Advanced Circuit Therapeutics will challenge existing limitations of science and medicine to help create and discover new treatments for neuropsychiatric disorders that were never before thought possible.”
Dr. Mayberg received an MD from the University of Southern California. She trained at the Neurological Institute of New York at Columbia University and was a post-doctoral fellow in nuclear medicine at Johns Hopkins Medicine. Immediately prior to joining Mount Sinai, Dr. Mayberg was Professor of Psychiatry, Neurology, and Radiology and held the inaugural Dorothy C. Fuqua Chair in Psychiatric Neuroimaging and Therapeutics at Emory University School of Medicine.
“Dr. Mayberg is truly one of the disruptors who have helped rethink the way we study the brain mechanisms underlying major depression,” says Kenneth L. Davis, MD, President and Chief Executive Officer of the Mount Sinai Health System. “Under her leadership, we will bring together Mount Sinai’s core competencies in imaging, bioinformatics, and clinical trials to vigorously advance breakthrough, precision treatments for a disease that affects so many lives.”
As Director of The Center for Advanced Circuit Therapeutics at Mount Sinai, Dr. Mayberg will build a cross-disciplinary platform for collaborative translational research that will bring together clinical colleagues in neurology, neurosurgery, and psychiatry with experts from neuroscience, imaging, engineering, bioinformatics, neuro-engineering, and computational neuroscience to foster the development of new circuit-based strategies and delivery of state-of-the art individualized treatments for patients with advanced neuropsychiatric disorders.
“Our aim is to catalyze a clinical and scientific culture shift that challenges traditional approaches to diagnosis, treatment, and collaboration in service to the development of novel circuit-tuning strategies and delivery of more precise, individualized treatments for patients with advanced neuropsychiatric disorders, be it those for which brain stimulation therapies are already clinically available, like Parkinson’s disease and epilepsy or for more experimental applications such as depression, obsessive-compulsive disorder, eating disorders, and addiction,” says Dr. Mayberg. “The esteemed faculty at Mount Sinai put us in the perfect position to accomplish these breakthrough goals.”
A close partnership between Dr. Mayberg and Brian Kopell, MD, a pioneer of deep brain stimulation and Director of the Center for Neuromodulation within the Department of Neurosurgery at Mount Sinai, will be paramount to the success of the new Center. Dr. Mayberg will also establish ties between the Center and the many basic and clinical researchers across the Mount Sinai Health System focused on neuropsychiatric disorders. In particular, she will work closely with experts from the Movement Disorders Program; the Mood and Anxiety Disorders Program (MAP); the Translational and Molecular Imaging Institute; The Friedman Brain Institute; and many departments and divisions across the Icahn School of Medicine and within the Mount Sinai Health System.
About the Mount Sinai Health System
The Mount Sinai Health System is New York City's largest integrated delivery system, encompassing eight hospitals, a leading medical school, and a vast network of ambulatory practices throughout the greater New York region. Mount Sinai's vision is to produce the safest care, the highest quality, the highest satisfaction, the best access and the best value of any health system in the nation. The Health System includes approximately 7,480 primary and specialty care physicians; 11 joint-venture ambulatory surgery centers; more than 410 ambulatory practices throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and 31 affiliated community health centers. The Icahn School of Medicine is one of three medical schools that have earned distinction by multiple indicators: ranked in the top 20 by U.S. News & World Report's "Best Medical Schools", aligned with a U.S. News & World Report's "Honor Roll" Hospital, No. 12 in the nation for National Institutes of Health funding, and among the top 10 most innovative research institutions as ranked by the journal Nature in its Nature Innovation Index. This reflects a special level of excellence in education, clinical practice, and research. The Mount Sinai Hospital is ranked No. 14 on U.S. News & World Report's "Honor Roll" of top U.S. hospitals; it is one of the nation's top 20 hospitals in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Geriatrics, Gynecology, Nephrology, Neurology/Neurosurgery, and Orthopedics in the 2019-2020 "Best Hospitals" issue. Mount Sinai's Kravis Children's Hospital also is ranked nationally in five out of ten pediatric specialties by U.S. News & World Report. The New York Eye and Ear Infirmary of Mount Sinai is ranked 12th nationally for Ophthalmology and the South Nassau Communities Hospital is ranked 35th nationally for Urology. Mount Sinai Beth Israel, Mount Sinai St. Luke's, Mount Sinai West, and South Nassau Communities Hospital are ranked regionally.