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"Exploring Molecular And Sex-Based Differences In Depression" - Allison Inserro

  • AJMC News
  • New York, NY
  • (May 10, 2018)

It is now known that early life stress may have an impact on adults later in life, and that men and women may respond to depression differently, but why that is so is not thoroughly understood. At the 73rd Annual Scientific Convention of the Society of Biological Psychiatry meeting in New York, Eric Nestler, MD, PhD, dean of academic and scientific affairs and director of the Friedman Brain Institute at the Icahn School of Medicine at Mount Sinai, gave an opening plenary called “Sex Differences in the Molecular Basis of Depression.” Dr. Nestler studies the molecular mechanisms of depression and addiction in mice models. Depression is common, chronic, and debilitating, and current antidepressant therapies are not effective for everyone. The mechanisms that precipitate depression, such as stress, are incompletely understood. Another part of Dr. Nestler’s work looks at how early life stress increases lifelong stress susceptibility. Early life stress is one of the strongest known risk factors for depression.

- Eric Nestler, MD, PhD, Dean, Academic and Scientific Affairs, Director, Friedman Brain Institute, Professor, Neuroscience, Pharmacological Sciences, Psychiatry, Icahn School of Medicine at Mount Sinai

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