• Press Release

Sanford J. Grossman Charitable Trust Pledges $3 Million to Create Center for Integrative Studies in Inflammatory Bowel Disease at Mount Sinai

The Sanford J. Grossman Charitable Trust, founded by renowned economist and philanthropist Sanford J. Grossman, PhD, has committed $3 million to establish the Dr. Sanford J. Grossman Center for Integrative Studies in Inflammatory Bowel Disease.

  • New York
  • (April 27, 2015)

The Sanford J. Grossman Charitable Trust, founded by renowned economist and philanthropist Sanford J. Grossman, PhD, has committed $3 million to establish the Dr. Sanford J. Grossman Center for Integrative Studies in Inflammatory Bowel Disease at the Icahn School of Medicine at Mount Sinai. The Center will focus on creating personalized medicine for treatment of Crohn's disease, with the overarching goal of understanding and predicting disease progression.

Crohn's Disease, a chronic inflammatory disorder of the bowel first described by Mount Sinai gastroenterologist Burrill B. Crohn, MD, affects nearly 700,000 people in the United States according to the Crohn's & Colitis Foundation of America. Over time persistent inflammation can lead to bowel damage and create complications such as strictures, a narrowing section of the intestine that can lead to loss of function, reduce the quality of a patient's life and increase the need for surgical resection.

"Mount Sinai has a large and unique data set on patients: clinical symptoms and history, pathology reports on resected gut tissue, genomics and family history, and radiology," said Dr. Grossman. "My hope is that the integration and analysis of this data will enable a better understanding of the manifestations and natural histories of Crohn's Disease, and with that knowledge, therapies will be developed to beneficially alter the natural course of the disease. At the very least, I hope that there will be a better understanding of the biological processes that lead to various types of stricture formation, and some suggestions as to how strictures can be prevented," said Dr. Grossman.

"As leaders in IBD research, we appreciate the Sanford J. Grossman Charitable Trust's generous gift that will open a new area of investigation in Crohn's disease and help to provide a completely innovative approach to studying this chronic illness," says Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean of the Icahn School of Medicine at Mount Sinai and President for Academic Affairs for the Mount Sinai Health System.

Specifically, the Sanford J. Grossman Charitable Trust has committed $1 million, with an additional $2M to be received once the Center has reached milestones detailed in the agreement.

"There remains an enormous variability among patients as to who will develop conditions relating to IBD and their corresponding course of medical therapies," said Judy Cho, MD, Ward-Coleman Professor of Translational Genetics and Medicine and Vice-Chair of Translational Genetics and Gastroenterology, and the new Grossman Center's Director at the Icahn School of Medicine at Mount Sinai. "We are very grateful for Dr. Grossman's donation, which will fund this unique, integrative team and catalyze new research that will help us to more precisely understand individual patients with Crohn's disease and how to tailor therapies most effectively," said Dr. Cho.

"Dr. Grossman's magnificent generosity will enable an ideal collaboration among some of the nation's leading basic research scientists and clinician scientists in IBD, to distinguish different Crohn's disease types to better understand the disease course and selection of personalized therapies. It is the ideal paradigm of translational research," said Asher Kornbluth, MD, Clinical Professor of Medicine and Gastroenterology at the Icahn School of Medicine.

The Center will bring together a multidisciplinary group that will work to determine the fundamental mechanisms of intestinal inflammation and cellular differentiation and hypertrophy leading to formation of strictures in Crohn's disease. A team of investigators comprised of pathologists, radiologists, geneticists, immunologists and gastroenterologists will focus on more precise pathologic and radiologic evaluation, improved tissue banking systems, genetic and cellular analyses, and the integration of basic science and clinical discoveries.

About the Mount Sinai Health System

The Mount Sinai Health System is New York City's largest integrated delivery system, encompassing eight hospitals, a leading medical school, and a vast network of ambulatory practices throughout the greater New York region. Mount Sinai's vision is to produce the safest care, the highest quality, the highest satisfaction, the best access and the best value of any health system in the nation. The Health System includes approximately 7,480 primary and specialty care physicians; 11 joint-venture ambulatory surgery centers; more than 410 ambulatory practices throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and 31 affiliated community health centers. The Icahn School of Medicine is one of three medical schools that have earned distinction by multiple indicators: ranked in the top 20 by U.S. News & World Report's "Best Medical Schools", aligned with a U.S. News & World Report's "Honor Roll" Hospital, No. 12 in the nation for National Institutes of Health funding, and among the top 10 most innovative research institutions as ranked by the journal Nature in its Nature Innovation Index. This reflects a special level of excellence in education, clinical practice, and research. The Mount Sinai Hospital is ranked No. 18 on U.S. News & World Report's "Honor Roll" of top U.S. hospitals; it is one of the nation's top 20 hospitals in Cardiology/Heart Surgery, Gastroenterology/GI Surgery, Geriatrics, Nephrology, and Neurology/Neurosurgery, and in the top 50 in six other specialties in the 2018-2019 "Best Hospitals" issue. Mount Sinai's Kravis Children's Hospital also is ranked nationally in five out of ten pediatric specialties by U.S. News & World Report. The New York Eye and Ear Infirmary of Mount Sinai is ranked 11th nationally for Ophthalmology and 44th for Ear, Nose, and Throat. Mount Sinai Beth Israel, Mount Sinai St. Luke's, Mount Sinai West, and South Nassau Communities Hospital are ranked regionally.

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