Mount Sinai Researcher Receives NIH Award to Study Immune Responses of Patients With Inflammatory Skin Diseases in the Setting of COVID-19 Infection
Patients with moderate to severe atopic dermatitis (also known as eczema) who take a biologic treatment such as dupilumab seem to be protected from developing serious complications of COVID-19 and are also less likely to be hospitalized due to complications. Now, researchers from the Icahn School of Medicine at Mount Sinai have received a grant from the National Institutes of Health (NIH) on behalf of the National Institute of Allergy and Infectious Disease (NIAID) to study the immune responses of these patients in the setting of COVID-19 infection.
This two-year award is an addition to a seven-year grant also awarded by the NIH/NIAID to study mechanisms leading to variations in atopic dermatitis phenotypes. The total grant amounts to over $2 million.
The study will aim to understand whether systemic medications and biologics, such as dupilumab—a monoclonal antibody that binds to an inflammatory molecule, IL-4 receptor alfa, and inhibits the inflammatory response that leads to rashes and itching from atopic dermatitis/eczema—may have a positive or negative impact on COVID-19 responses in patients who have the disease.
“This research project has the potential to directly impact the medical care of tens of thousands of patients in the United States with atopic dermatitis on systemic medications in the setting of the COVID-19 pandemic, reducing morbidity and mortality, particularly in populations disproportionately affected, such as African Americans,” said Emma Guttman-Yassky, MD, PhD, Sol and Clara Kest Professor of Dermatology and Vice Chair of the Department of Dermatology at Icahn School of Medicine at Mount Sinai and grant recipient.
According to Dr. Guttman-Yassky, ethnic populations including African Americans are more affected by severe atopic dermatitis/eczema and also have a higher prevalence of asthma along with other risk factors such as diabetes and hypertension.
Dr. Guttman-Yassky hopes the study will help to determine whether systemic treatments, including specific monoclonal antibodies impact responses to COVID-19 infection, and whether some of these treatments can protect from deleterious COVID-19 effects.
“Understanding these immune responses in the presence of patients with atopic dermatitis is extremely important as it will help to guide how we treat patients with COVID-19 during this very critical period and help provide a possible new treatment directed towards this virus,” she said.
Mount Sinai’s dermatology practices have more than 1,200 moderate-to-severe atopic dermatitis patients who are taking dupilumab. And while the data is still preliminary, according to Dr. Guttman-Yassky, no patients have been reported in her practice as being hospitalized with COVID-19, although many have been exposed to the disease.
With such a large database of Mount Sinai patients with atopic dermatitis, Dr. Guttman-Yassky also hopes to determine ethnic differences in mounting COVID-19 responses in the setting of systemic and biologic treatments.
“Having a better understanding of differential immune responses mounted to COVID-19 may offer a basis for evaluating additional therapeutic approaches for this disease and other infections,” she said.
About the Mount Sinai Health System
The Mount Sinai Health System is New York City's largest academic medical system, encompassing eight hospitals, a leading medical school, and a vast network of ambulatory practices throughout the greater New York region. Mount Sinai advances medicine and health through unrivaled education and translational research and discovery to deliver care that is the safest, highest-quality, most accessible and equitable, and the best value of any health system in the nation. The Health System includes approximately 7,300 primary and specialty care physicians; 13 joint-venture ambulatory surgery centers; more than 415 ambulatory practices throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. The Mount Sinai Hospital is ranked on U.S. News & World Report's "Honor Roll" of the top 20 U.S. hospitals and is top in the nation by specialty: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. Mount Sinai Kravis Children's Hospital is ranked in U.S. News & World Report’s “Best Children’s Hospitals” among the country’s best in four out of 10 pediatric specialties. The Icahn School of Medicine is one of three medical schools that have earned distinction by multiple indicators: ranked in the top 20 by U.S. News & World Report's "Best Medical Schools," aligned with a U.S. News & World Report "Honor Roll" Hospital, and No. 14 in the nation for National Institutes of Health funding. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.