"Study Reveals New Genetic Link to Heart Disease"
Researchers at the Icahn School of Medicine at Mount Sinai have demonstrated that more than 30 percent of heart disease risk stems from genetic factors, much more than was previously understood. The study findings, published today in the Journal of the American College of Cardiology, introduce the biology of gene networks as a means to better understand the heritability and genetic underpinnings of heart disease. “The results of this study demonstrate that the risk of heart disease is a concerted result of interactions between genetic variants and biological environments," said Johan LM Björkegren, MD, PhD, professor of medicine, cardiology, genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai. “By understanding the complex relationship between the two, we've created a framework for identifying new risk genes in disease-relevant tissues leading to heart disease, which in turn will allow for more effective risk prediction, clinical intervention, and eventually, opportunities for novel and more effective therapies."
— Johan LM Björkegren, MD, PhD, Professor, Medicine, Cardiology, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai