"Plaque in Arteries May Not All Be The Same; Targeting Specific Immune Cells in Plaque May Reduce Heart Attack and Stroke Risk"
A specific type of immune cell is more commonly found in arterial plaque from patients suffering from a recent stroke or mini-stroke, according to researchers at the Icahn School of medicine at Mount Sinai. The finding raises the possibility that targeted immune therapy might someday reduce the onset of heart attack and stroke in high-risk patients. Presenting at the American Heart Association’s Vascular Discovery Scientific Session, senior author Chiara Giannarelli, MD, PhD, assistant professor of medicine, cardiology, genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai said, “Despite decades of research, we don’t know how to predict and prevent plaque from rupturing in the arteries.” Dr. Giannarelli added, “Most of the research has involved looking at human tissue under the microscope. This has helped us better understand many features of ruptured plaque, but little is known about how and which individual cells types contribute the most to ruptures causing stroke or heart attack.”
— Chiara Giannarelli, MD, PhD, Assistant Professor, Medicine, Cardiology, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai