Mount Sinai Researchers Find That Most Adults Born Prematurely Survive Without Major Comorbidities
Outcomes were worse for those born extremely preterm
Most people born prematurely are likely to survive into adulthood without developing major chronic diseases or conditions like asthma, hypertension, diabetes, and other illnesses, Mount Sinai researchers report in a study published today in the Journal of the American Medical Association (JAMA).
“This study provides the first population-based estimates of the prevalence of survival without major comorbidities in adults born prematurely,” says corresponding author Casey Crump, MD, PhD, Vice Chair for Research of the Alfred and Gail Engelberg Department of Family Medicine and Community Health, Icahn School of Medicine at Mount Sinai. “The relatively high prevalence of this positive outcome in the population studied reflects not only the treatment advances that have occurred over the past 50 years, but the apparent resilience of people who survived preterm birth in maintaining good health. While the results are promising, they call for further investigation to identify protective factors that will enhance the long-term health trajectory of people who were born prematurely.”
The researchers studied the health of more than 2.5 million people in Sweden who were born from 1973 to 1997, all of whom were followed up for survival and comorbidities through 2015. Of this group, 55 percent who were born preterm (a gestational age less than 37 weeks), and 22 percent born extremely preterm (a gestational age of 22 to 27 weeks), were alive with no major comorbidities at ages 18 to 43 years, compared to 63 percent of people in Sweden who were born full-term (a gestational age of 39 to 41 weeks).
The findings were similar among men and women and were independent of birth year and other perinatal or maternal factors. In addition, co-sibling analyses suggested that the prevalence of survival without comorbidities was not due to shared genetic or environmental factors in families. Limitations of the study include the fact that detailed clinical data weren’t available to validate health conditions and longer follow- up is needed to examine outcomes after the age of 43.
Prior studies of long-term health consequences of preterm birth have focused almost entirely on specific adverse outcomes, either physical, mental, or social. Such studies have reported that people born prematurely have increased risks of cardiometabolic, respiratory, and neuropsychiatric disorders; social adversity; and premature mortality in young adulthood. Potential positive outcomes or indicators of resilience have rarely been assessed.
Additional studies are needed to identify protective factors across life that enhance resilience and the long-term health of people who were born prematurely, particularly at the earliest gestational ages.
“A key strength of this study is its ability to assess an extensive range of comorbidities in a large cohort of people with follow-up into early to mid-adulthood, using birth, medical, and pharmacy registry data,” says Kristina Sundquist, MD, PhD, Professor and Family Physician, Lund University, Sweden, a study author and co-investigator. “This study design minimized potential selection bias and enabled more robust estimates based on a national population.”
The U.S. National Heart, Lung, and Blood Institute at the U.S. National Institutes of Health supported the study, as did the Swedish Research Council, the Swedish Heart-Lung Foundation and ALF project grant, Region Skane/Lund University, Sweden.
About the Mount Sinai Health System
The Mount Sinai Health System is New York City's largest integrated delivery system, encompassing eight hospitals, a leading medical school, and a vast network of ambulatory practices throughout the greater New York region. Mount Sinai's vision is to produce the safest care, the highest quality, the highest satisfaction, the best access and the best value of any health system in the nation. The Health System includes approximately 7,480 primary and specialty care physicians; 11 joint-venture ambulatory surgery centers; more than 410 ambulatory practices throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and 31 affiliated community health centers. The Icahn School of Medicine is one of three medical schools that have earned distinction by multiple indicators: ranked in the top 20 by U.S. News & World Report's "Best Medical Schools", aligned with a U.S. News & World Report's "Honor Roll" Hospital, No. 12 in the nation for National Institutes of Health funding, and among the top 10 most innovative research institutions as ranked by the journal Nature in its Nature Innovation Index. This reflects a special level of excellence in education, clinical practice, and research. The Mount Sinai Hospital is ranked No. 14 on U.S. News & World Report's "Honor Roll" of top U.S. hospitals; it is one of the nation's top 20 hospitals in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Geriatrics, Gynecology, Nephrology, Neurology/Neurosurgery, and Orthopedics in the 2019-2020 "Best Hospitals" issue. Mount Sinai's Kravis Children's Hospital also is ranked nationally in five out of ten pediatric specialties by U.S. News & World Report. The New York Eye and Ear Infirmary of Mount Sinai is ranked 12th nationally for Ophthalmology, Mount Sinai St. Lukes and Mount Sinai West are ranked 23rd nationally for Nephrology and 25th for Diabetes/Endocrinology, and Mount Sinai South Nassau is ranked 35th nationally for Urology. Mount Sinai Beth Israel, Mount Sinai St. Luke's, Mount Sinai West, and Mount Sinai South Nassau are ranked regionally.