"Gene Regulators Work Together For Oversized Impact On Schizophrenia Risk"
Researchers at the Icahn School of Medicine at Mount Sinai have discovered that gene expression regulators work together to raise an individual’s risk of developing schizophrenia. The researchers, led by Kristen Brennand, PhD, associate professor of neuroscience, genetics and genomic sciences, and psychiatry at the Icahn School of Medicine at Mount Sinai, reported their findings in Nature Genetics. “This unexpected synergy between gene variants demonstrated how even subtle genetic variations can impact neuronal function,” said Dr. Brennand. She added, “These interactions emphasize the importance of considering the complex nature of schizophrenia and other psychiatric disorders, where a combination of gene variants contributes to disease.”
— Kristen Brennand, PhD, Associate Professor, Neuroscience, Genetics and Genomic Sciences, Psychiatry, Icahn School of Medicine at Mount Sinai