$1.5 Million NIH Grant to Fund Mount Sinai Study of Environmental Toxin Impact on Fetal Development
The National Institutes of Health (NIH) has awarded Manish Arora, BDS, PhD, MPH, Assistant Professor of Preventive Medicine at the Icahn School of Medicine at Mount Sinai, a 2014 New Innovator Award. Dr. Arora will receive a $1.5 million grant towards studying the impact of environmental toxins and stress on fetal development. This is the first time that the National Institute of Environmental Health Sciences (NIEHS), one of the 27 research centers that comprise the NIH, has presented a Young Innovator Award. The award will be formally announced during the 2014 High Risk High Reward Symposium at the NIH headquarters in Bethesda, MD, in December.
“From identifying the most hazardous industrial chemicals to studying the impact of those chemicals on the developing brain, Mount Sinai has led the way in environmental health, and we are pleased that the NIH recognizes the important work done by Dr. Arora and his research team,” said Philip J. Landrigan, MD, MSc, Ethel H. Wise Professor & Chair, Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, and Director of the Children’s Environmental Health Center at Mount Sinai.
Dr. Arora and his team have proposed to develop a new methodology to study how fetal development may be changed by environmental toxins, as well as the associated risks of long-term health disorders. Past animal studies show that certain pollutants in the environment can impair the development of the brain, for instance, and preventive health experts hope to confirm such effects as a precursor to regulations that protect public health.
The team’s proposed methodology provides a window into the past and imparts critical information about toxic exposures dating as far back as the prenatal period. The team will retrospectively reconstruct fetal exposure to environmental toxicants with the aim of identifying not only how much of a harmful chemical an individual was exposed to, but also when that exposure occurred, even if it was before birth. For the first time, case-control studies can obtain time-series data on early life environmental exposures. Not only does the team aim to develop laboratory analytical techniques, but they will also develop novel, statistical modeling approaches that enable the rapid translation of information for public health application.
“We now recognize that measuring exposure to environmental toxins, in and of itself, is not sufficient to study health risks: whether exposure to such toxicants results in disruption of key physiological pathways ultimately increases the risk of a clinically detectable disease,” said Dr. Arora. “This fundamentally new methodology is based on laboratory methods we developed, and we are grateful to the NIH for supporting this critically important research.”
About the Mount Sinai Health System
The Mount Sinai Health System is New York City's largest integrated delivery system, encompassing eight hospitals, a leading medical school, and a vast network of ambulatory practices throughout the greater New York region. Mount Sinai's vision is to produce the safest care, the highest quality, the highest satisfaction, the best access and the best value of any health system in the nation. The Health System includes approximately 7,480 primary and specialty care physicians; 11 joint-venture ambulatory surgery centers; more than 410 ambulatory practices throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and 31 affiliated community health centers. The Icahn School of Medicine is one of three medical schools that have earned distinction by multiple indicators: ranked in the top 20 by U.S. News & World Report's "Best Medical Schools", aligned with a U.S. News & World Report's "Honor Roll" Hospital, No. 12 in the nation for National Institutes of Health funding, and among the top 10 most innovative research institutions as ranked by the journal Nature in its Nature Innovation Index. This reflects a special level of excellence in education, clinical practice, and research. The Mount Sinai Hospital is ranked No. 18 on U.S. News & World Report's "Honor Roll" of top U.S. hospitals; it is one of the nation's top 20 hospitals in Cardiology/Heart Surgery, Gastroenterology/GI Surgery, Geriatrics, Nephrology, and Neurology/Neurosurgery, and in the top 50 in six other specialties in the 2018-2019 "Best Hospitals" issue. Mount Sinai's Kravis Children's Hospital also is ranked nationally in five out of ten pediatric specialties by U.S. News & World Report. The New York Eye and Ear Infirmary of Mount Sinai is ranked 11th nationally for Ophthalmology and 44th for Ear, Nose, and Throat. Mount Sinai Beth Israel, Mount Sinai St. Luke's, Mount Sinai West, and South Nassau Communities Hospital are ranked regionally.