News-Medical.net - "Tumor Suppressor Mutant May Predict Poor Outcome in Breast Cancer"
An oncogenic variant of the Krüppel-like family (KLF) 6 tumor suppressor gene appears to play a role in driving breast cancer metastasis and may be a prognostic marker for poor patient outcome, according to researches quoted in Science Translational Medicine. Dr. Goutham Narla and colleagues from the Icahn School of Medicine at Mount Sinai performed multivariate analysis for metastasis-free survival (MFS) in 671 primary breast cancer patients. They found that increased expression of KLF6-SV1 mRNA in primary tumors was associated with a decreased likelihood for MFS, after adjustment for traditional confounders such as age, menopausal status, tumor size, grade, and steroid hormone receptor levels. The researchers say that KLF6-SV1 over expression in breast cancer patients could potentially identify a distinct population whose tumors might need to be treated more aggressively because of their increased propensity to metastasize. Learn more