New Haven Register - "Yale Researchers: 'Magic' Antidepressant May Hold Promise For PTSD"
Ketamine — used as an anesthetic in human and veterinary medicine — has emerged in the past few years as a promising, rapid-acting antidepressant. When administered intravenously at low doses, it can lift symptoms of deep depression within hours, for seven to 10 days. Typical antidepressants, which act on the neurotransmitter serotonin, take a month or more for full effect. Researchers at Yale, the VA Connecticut Healthcare System, Mount Sinai School of Medicine and other institutions are pursuing early indications that ketamine may have some benefit for post-traumatic stress disorder (PTSD) and alcohol addiction. At Mount Sinai, Dr. Dennis Charney and colleagues are testing whether a single dose of ketamine can reduce core symptoms of PTSD, a debilitating anxiety disorder that afflicts an estimated one in five combat veterans returning from Iraq and Afghanistan. "Better treatments are needed for PTSD because of the seriousness of the disorder, and available treatments are generally only partially effective," said Dr. Charney, dean of Mount Sinai School of Medicine. Learn more