Genetic Engineering News - "Exploiting miRNA’s Potential for Diagnostics and Drugs"
miRNAs have emerged as regulators of genes that play a role in many cellular processes and signaling pathways. Benjamin tenOever, PhD, Fishberg professor of medicine at the Icahn School of Medicine at Mount Sinai, has been investigating how miRNAs can be utilized in engineered RNA-based vectors. "Because viruses lack a mechanism for antagonizing miRNA function, we can exploit miRNA expression to control viruses," he says. "We have shown that if you incorporate targets for a cell-specific miRNA into an RNA virus genome, you can create a virus that looks identical at a protein level but would be selectively blocked from infecting these particular cells." Learn more