"Mount Sinai Team Demonstrates Abilities of Proteogenomic Analysis Software" - Adam Bonislawski
A team led by researchers at the Icahn School of Medicine at Mount Sinai have developed a software tool for proteogenomic analyses. In a paper published this month in Molecular & Cellular Proteomics, they described using the tool, named iProFun, to analyze genomic, transcriptomic, proteomic, and phosphoproteomic ovarian cancer data. “The ability to combine multiple levels of omics data provides better statistical power for confidently detecting links between alterations at the DNA level and changes to other molecules like proteins or phosphoproteins,” said Pei Wang, PhD, professor of genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai. She added, “With studies with a genomic focus, people have usually tried to use RNA analysis to see what the effects are of mutations or copy number or methylation in the functional domain.”
— Pei Wang, PhD, Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai