The Role of the Gastrointestinal-associated Lymphoid Tissue in the Cure of HIV Infection
The objective of this study is to understand the effects of HIV cure strategies on the virus
and immune cells that reside within the gastrointestinal tract. Subjects receiving therapies
with the potential for HIV cure will undergo a colonoscopy to obtain gastrointes...
Age: 18 - 75 years
Gender: All
Cholesterol Lowering and Residual Risk in Diabetes, Type 1
This is a prospective, interventional, cohort study, meaning that researchers will follow and observe a group of enrolled study participants over a period of time (one to two months) to gather information and record any developments of the outcomes in question. This stu...
Age: 18 - 89 years
Gender: All
RECOVER-VITAL: Platform Protocol to Measure the Effects of Antiviral Therapies on Long COVID Symptoms
This study is a platform protocol designed to be flexible so that it is suitable for a
wide range of settings within health care systems and in community settings where it can
be integrated into COVID-19 programs and subsequent treatment plans. This protocol is a
pro...
Age: 18 years - 66+
Gender: All
Study of Epetraborole in Patients With Treatment-refractory MAC Lung Disease
This pivotal Phase 2/3, double-blind, placebo-controlled study of epetraborole + OBR
(Optimized Background Regimen) versus placebo + OBR in patients with treatment-refractory MAC
lung disease. This study will enroll adult patients with treatment-refractory MAC lung
...
Age: 18 years - 66+
Gender: All
A Study to Evaluate Efficacy and Safety of Casirivimab+Imdevimab (Monoclonal Antibodies) for Prevention of COVID-19 in Immunocompromised Adolescents and Adults
The primary objective of the study is to evaluate the effect of casirivimab+imdevimab, compared with placebo, in preventing symptomatic SARS-CoV-2 infection in immunocompromised participants. The secondary objectives of the study are: - To evaluate the safety and tolera...
Age: 12 years - 66+
Gender: All
Renal Allograft Fibrosis Study
Despite the reduction in acute rejection episodes in renal transplant patients due to
modern immunosuppression, proportionate improvements in long-term allograft survival have
not been achieved. Virtually any disease or injury affecting renal allografts can
culminate...
Age: 18 years - 66+
Gender: All
Outpatient Treatment With Anti-Coronavirus Immunoglobulin
The primary objective of the Outpatient Treatment with Anti-Coronavirus Immunoglobulin
(OTAC) (INSIGHT 012) trial is to compare the safety and efficacy of a single infusion of
anti-COVID-19 hyperimmune intravenous immunoglobulin (hIVIG) versus placebo among adults
wi...
Age: 18 years - 66+
Gender: All
Early Feeding After Oral Cavity Reconstruction
This is a prospective single-arm non-inferiority trial evaluating surgical outcomes in
subjects who are fed in the first days after oral cavity reconstructive surgery. The purpose
of the study is to specifically compare the rates of orocutaneous fistula in subjects ...
Age: 18 years - 66+
Gender: All
Impact of COVID-19 on GU Disease
The purpose of this research study is to identify patients with GU disease with active or
past COVID-19 infection.
Participants will be asked to:
- Complete an Online COVID-19 Questionnaire.
- Disclose if the patient has or had Genitourinary cancer or beni...
Age: 40 years - 66+
Gender: All
Antithrombotic Therapy to Ameliorate Complications of COVID-19 ( ATTACC )
Endothelial injury as a consequence of SARS-CoV-2 infection leads to a dysregulated host
inflammatory response and activation of coagulation pathways. Macro- and micro-vascular
thrombosis may contribute to morbidity, organ failure, and death. Therapeutic anticoagulati...
Age: 18 years - 66+
Gender: All
Antithrombotic Therapy to Ameliorate Complications of COVID-19 ( ATTACC )
Endothelial injury as a consequence of SARS-CoV-2 infection leads to a dysregulated host inflammatory response and activation of coagulation pathways. Macro- and micro-vascular thrombosis may contribute to morbidity, organ failure, and death. Therapeutic anticoagulation...
Age: 18 years - 66+
Gender: All
A Double-Masked, Placebo-Controlled, Randomized, Phase II Clinical Trial To Assess The Efficacy Of SCH1 In The Treatment Of Acute Infectious Conjunctivitis
Acute infectious conjunctivitis is a leading cause of ocular morbidity, epidemic eye infection, lost productivity, patient discomfort and in some cases permanent visual compromise. The infectious agent is frequently viral in origin and frequently bacterial in origin wit...
Age: 18 - 90 years
Gender: All
To Compare Ridinilazole Versus Vancomycin Treatment for Clostridium Difficile Infection
Summit is developing ridinilazole as a novel antimicrobial for Clostridium difficile
Infection (CDI), formerly known as Clostridium difficile Infection, with the goal of
achieving comparable cure rates to standard of care, but reducing rates of recurrent disease.
...
Age: 18 years - 66+
Gender: All
The Mount Sinai Diabetic Foot Ulcer Prospective Trial
The purpose of this study is to evaluate whether placing stent(s) for a blockage in a leg
vein will help improve the healing of diabetic foot ulcers (DFU). The investigators know from
having taken care of many patients with diabetic foot ulcers that it is a major ca...
Age: 30 - 64 years
Gender: All
Standardized Treatment of Pulmonary Exacerbations II
Cystic fibrosis (CF), a life-shortening genetic disease, is marked by acute episodes during
which symptoms of lung infection increase and lung function decreases. These pulmonary
exacerbations are treated with varying antibiotics for varying time periods based on need...
Age: 18 years - 66+
Gender: All
Safety of FMT: OpenBiome Outcomes and Longitudinal Follow-up (STOOL) for Recurrent Clostridium Difficile Infection
The overarching objective of this study is to address the knowledge gap regarding the short-term and long-term safety of fecal microbiota transplants (FMT). The design will be a prospective, open-label, multi-center longitudinal cohort study to assess the short- and lon...
Age: 18 years - 66+
Gender: All
A Study of Rivaroxaban (JNJ-39039039) on the Venous Thromboembolic Risk in Post-Hospital Discharge Patients
The purpose of this study is to evaluate the efficacy and safety of rivaroxaban compared with
placebo in the prevention of symptomatic venous thromboembolism (VTE) events and VTE-related
death post-hospital discharge in high-risk, medically ill patients.
Age: 40 years - 66+
Gender: All