Methodology Issues in a Tailored Light Treatment for Persons With Dementia - Aim 2
Aim 2 will investigate the effect of 3 different light exposure lengths on sleep, mood and agitation in persons with Alzheimer's disease. Participants will be randomly assigned to one of three conditions of light exposure: 1) 2-h morning light exposure; 2) 4-h morning l...
Age: 65 years - 66+
Gender: All
Outcome of Patients With Severe Functional TR According to Medical, Transcatheter or Surgical Treatment
Tricuspid regurgitation (TR) is a public health problem: moderate / severe TR are common,
especially in ageing populations, and affect 4% of the population >75 years old, totaling
approximately 1.6 million in the US and 3 million in Europe. TR is associated with an
...
Age: 18 years - 66+
Gender: All
Efficacy, Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of BIA 28-6156 in GBA-PD
The purpose of this randomized, double-blind, placebo-controlled study is to assess the efficacy of BIA 28-6156 over placebo in delaying clinical meaningful motor progression over 78 weeks in subjects with Parkinson's disease who have a pathogenic variant in the glucoce...
Age: 35 - 80 years
Gender: All
Thulium vs. Hol:YAG Laser
This is a randomized prospective study to compare stone free rates and operative efficiency of two laser systems used during retrograde intrarenal surgery for kidney stone disease: 1. A superpulsed thulium fiber laser (thulium) 2. A pulse modulated high power holmium la...
Age: 18 years - 66+
Gender: All
Ruxolitinib in Seborrheic Dermatitis
This study is an open-label prospective interventional trial that will assess the efficacy of
ruxolitinib in the treatment of seborrheic dermatitis. It will also attempt to characterize
the molecular immune profiles of patients with SD at week 0 and week 4, with com...
Age: 18 years - 66+
Gender: All
DBS for TRD With the Medtronic Percept PC
Of the estimated 30 million Americans who suffer from Major Depressive Disorder, approximately 10% are considered treatment resistant. Deep brain stimulation (DBS) to a region of the brain called the subcallosal cingulate (SCC) is an emerging strategy for treatment resi...
Age: 25 - 70 years
Gender: All
The Effect of a Lighting Intervention on Sleep in Parkinson Disease
50 participants with Parkinson's disease will be recruited to complete actigraphy studies to assess sleep disturbances. For this, participants will wear an Actigraph for seven days. Thirty of these participants with sleep disturbance will go on to receive a tailored lig...
Age: 18 years - 66+
Gender: All
Electrophysiological Read-Out of Interoceptive Processing
Interoception, or sensation from inside the body, is involved in a variety of clinical symptoms, such as tics, compulsions and negative mood. This study uses invasive recordings of brain activity and brain stimulation to better understand basic neural mechanisms of inte...
Age: 18 years - 66+
Gender: All
Lighting Intervention to Improve Sleep
50 participants with Parkinson's disease will be recruited to complete actigraphy studies to assess sleep disturbances. For this, participants will wear an Actigraph for seven days. Thirty of these participants with sleep disturbance, will go on to receive a tailored li...
Age: 18 years - 66+
Gender: All
The Ambient Light Multiple Myeloma Study
The aim of this multi-site randomized control trial will be is to assess the impact Systematic lighting on circadian rhythm entrainment, Inflammation, Neutropenic Fever and Symptom Burden among Multiple Myeloma Patients undergoing Autologous Stem Cell Transplantation. T...
Age: 21 years - 66+
Gender: All
Postpartum Continuous Glucose Monitoring (CGM) Study
This research study is being done to assess if using a glucose sensor (also known as a continuous glucose monitor) after childbirth can help identify women who are at risk of developing diabetes after having diabetes during pregnancy or gestational diabetes. Currently, ...
Age: 18 years - 66+
Gender: Female
NRF for Improved Re-Entry Outcomes for Offenders With Brain Injury (Brain Injury RE)
The purpose of this study is to evaluate the effectiveness of NeuroResource Facilitation, a
novel/innovative intervention, in reducing recidivism in offenders with brain injury (BI).
Age: 18 years - 66+
Gender: Male
A Study to Learn About a Modified RNA Vaccine Against Shingles in Healthy Adults
The purpose of this clinical study is to learn about the safety, extent of the side effects
(reaction to vaccine), and immune response (your immune system's reaction) of the study
vaccine called Varicella Zoster Virus modRNA (VZV modRNA). We are seeking for healthy
...
Age: 50 - 69 years
Gender: All
Vagal Nerve Stimulation in Enhanced Stroke Recovery: The VALOR Registry
Vagal Nerve Stimulation is a novel proven therapy for patients with chronic ischemic stroke. The primary objective of this registry is to assess the safety of vagal nerve stimulation for stroke recovery through monitoring the occurrence of serious adverse events associa...
Age: 18 years - 66+
Gender: All
A Study to Learn More About Asundexian (Also Called BAY2433334) for Prevention of Ischemic Stroke in Male and Female Participants Aged 18 Years and Older Who Already Had Such a Stroke Due to a Blood Clot That Formed Outside the Heart and Travelled to the Brain, or Temporary Stroke-like Symptoms
Researchers are looking for a better way to prevent an ischemic stroke which occurs when a
blood clot travelled to the brain in people who within the last 72 hours had:
- a stroke due to a blood clot that formed outside the heart (acute non-cardioembolic
ischemi...
Age: 18 years - 66+
Gender: All
Effects of Stereotype Threat on Impulsivity and Its Relation to Alcohol Use in African Americans: An fMRI Study
The purpose of this study is to investigate the behavioral and neural correlates of stress exposure. Results from this study will enrich the understanding of how sociocultural, behavioral, and neural factors combine to influence alcohol use.
Age: 21 - 35 years
Gender: All
Transabdominal Plane (TAP) Blocks for Inguinal Hernia Repairs
The aim of this double-blind clinical trial is to examine outcomes and pain control after surgery in patients who underwent laparoscopic inguinal hernia repair (IHR) with the use of perioperative transabdominal plane (TAP) block. Research Question: Does transabdominal p...
Age: 18 years - 66+
Gender: All
MANTIS Endoscopic Clipping Study
This study is intended to document clinical effectiveness and safety pertaining to use of a
new endoscopic clipping device MANTIS™ when used for hemostasis, closure, anchoring and
marking.
Age: Birth - 66+
Gender: All
Prophylaxis With Direct-acting Antivirals for Kidney Transplantation From HCV-Infected Donors to Uninfected Recipients
This study is being done to find out the best time to start medication for Hepatitis C Virus
(HCV) in HCV-negative recipients of HCV-positive (HCV D+/R-) kidney transplants. Participants
will be randomized into one of two groups:
Arm 1 - Prophylaxis: This group ...
Age: 18 years - 66+
Gender: All
The Role of the Gastrointestinal-associated Lymphoid Tissue in the Cure of HIV Infection
The objective of this study is to understand the effects of HIV cure strategies on the virus and immune cells that reside within the gastrointestinal tract. Subjects receiving therapies with the potential for HIV cure will undergo a colonoscopy to obtain gastrointestina...
Age: 18 - 75 years
Gender: All