Study of the Feasibility and Efficacy of PrednisonE for Non-specifiC pleuriTis
This research study aims to evaluate whether corticosteroids help prevent the recurrence of pleural effusions in patients with non-specific pleuritis diagnosed through pleural biopsy. It can lead to recurrent fluid buildup in the lungs, causing discomfort and requiring ...
Age: 18 years - 66+
Gender: All
Improving Medication Management in World Trade Center Responders
By 2030, the majority of World Trade Center (WTC) rescue and recovery workers
(responders) will be aged 65 and over and at risk for aging-related conditions and
consequences including the concurrent use of five or more medications (i.e.,
polypharmacy). The purpose of...
Age: 50 years - 66+
Gender: All
Acute Migraine Treatment in the ED With Gepants
This study evaluates the effectiveness of rimegepant 75 mg orally disintegrating tablet (ODT) single-dose or zavegepant 10 mg nasal spray single-dose as acute migraine treatments during Emergency Department (ED) encounters. Although these two calcitonin gene-related pep...
Age: 18 years - 66+
Gender: All
Moving Beyond Inflammation as a Therapeutic Target for Crohn's Disease
The purpose of this research study is to evaluate what type of treatment will be beneficial for people with Crohn's disease and difficult to treat inflammation in the small bowel. Current therapies are used to control the inflammation due to Crohn's disease in your dige...
Age: 18 - 80 years
Gender: All
Study of IgPro20 to Prevent Infection in People With Multiple Myeloma and Hypogammaglobulinemia
The main purpose of this study is to see if IgPro20 can prevent infection in people with
multiple myeloma (MM) who have hypogammaglobulinemia from receiving bispecific monoclonal
antibodies (BsAbs).
Age: 18 years - 66+
Gender: All
T1D Pregnancy & Me
T1D Pregnancy & Me will partner with pregnant participants living with type 1 diabetes
(T1D) in the United States to collect real-world data on management of T1D in pregnancy.
This is a remote study where participants can complete online surveys and share device
data...
Age: 18 years - 66+
Gender: Female
SAFE Nerve Sparing Guided by Micro-ultrasound (MUS)
Robotic-assisted radical prostatectomy (RALP) has become the standard of care in the
management of localized prostate cancer. However, post-prostatectomy erectile dysfunction
(ED) and urinary incontinence still pose a challenge that adversely affects the patient's
qu...
Age: 18 years - 66+
Gender: Male
Topical 0.5% Timolol Solution for Healing Lower Extremity Wounds
Topical timolol, a β2-Adrenergic receptor (B2AR) antagonist, has demonstrated promise in
wound healing over the past several years. The majority of the literature has evaluated
the use of topical timolol to shorten wound healing time in chronic wounds of
non-surgical...
Age: 18 years - 66+
Gender: All
Adjunctive Cannabidiol for Recovery From Opioid Study
The long-term goal of the project is to determine whether cannabidiol (CBD) can reduce craving and relapse in individuals with opioid use disorder (OUD). The first phase of this project was an open cross-over design study in healthy individuals to confirm the safety and...
Age: 18 - 65 years
Gender: All
Surveillance Versus Bronchoscopy After Airway Stenting
Randomized, pilot study that evaluates surveillance bronchoscopy versus no surveillance
for patients that undergo tracheobronchial stenting
Age: 18 years - 66+
Gender: All
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
This study is open to adults with chronic heart failure (HF) who have a reduced left ventricular ejection fraction (LVEF) of less than 40%. People can join the study if they have been diagnosed with chronic HF at least 3 months before the study. The purpose of this stud...
Age: 18 years - 66+
Gender: All
MAGIC Ruxolitinib for aGVHD
This clinical trial will study ruxolitinib-based treatment of acute
graft-versus-host-disease (GVHD) that developed following allogeneic hematopoietic cell
transplant. Acute GVHD occurs when donor cells attack the healthy tissue of the body. The
most common symptoms ...
Age: 18 years - 66+
Gender: All
A Study to Assess Efficacy and Safety of JNJ-77242113 Compared to Placebo and Ustekinumab in Participants With Moderate to Severe Plaque Psoriasis
The main purpose of this study is to assess how well JNJ-77242113 works when compared to placebo and ustekinumab in participants with moderate to severe plaque psoriasis.
Age: 12 years - 66+
Gender: All
Adult Congenital Heart Disease International EValuation of the Effectiveness of SGLT2i Registry
This real-world, international registry aims to evaluate the current experience with
sodium-glucose cotransporter 2 inhibitors (SGLT2i) in adult congenital heart disease
(ACHD) patients by investigating the prescription patterns, safety, tolerability, and
potential b...
Age: 18 years - 66+
Gender: All
Paired Vagus Nerve Stimulation in Mobilization of Patients With Prolonged Disorders of Consciousness
Prolonged disorders of consciousness (pDOC) are defined as DOC lasting >1 year post
injury for patients with Traumatic Brain Injury (TBI) and >3 months post injury for
patients with non-TBI and at present there are limited treatments that reliably lead to
enhanced pr...
Age: 22 years - 66+
Gender: All
Parent-Child EF Intervention
Koronis Biomedical Technologies Corporation (KBT) is developing a cognitive intervention
to promote healthy development of Executive Function (EF) skills in young children by
leveraging a smartphone-based training regime designed for parents.
Age: 2 - 5 years
Gender: All
A Study of Efimosfermin Alfa in Participants With Biopsy-confirmed Cirrhosis (Compensated) MASH
The purpose of this study is to evaluate the safety, tolerability, preliminary efficacy,
and pharmacokinetics (PK) of efimosfermin in participants with metabolic dysfunction
associated steatohepatitis (MASH) and compensated cirrhosis consistent with stage F4
fibrosis...
Age: 18 - 75 years
Gender: All
Human Milk Research Study
What is the purpose of the study?
The maternal RSV vaccine was licensed in 2023 for prevention of RSV-associated lower respiratory tract disease in infants up to six months of age. Maternal immunization protects infants via antibodies transferred in utero. Additional be...
Age: 18 - 50 years
Gender: Female
Study of Bitopertin in Participants With EPP or XLP (APOLLO)
The goal of this clinical trial is to learn if bitopertin works and is safe to treat EPP or XLP in participants 12 years or older. The main questions it aims to answer are: - Whether bitopertin increases pain-free sunlight exposure after 6 months of treatment in partici...
Age: 12 years - 66+
Gender: All
Optimal Number of Pleural Biopsies During Pleuroscopy
A single-center, non-randomized, prospective observational, pilot study designed to
determine what is the optimal number of pleural biopsies to take during pleuroscopy.
Age: 18 years - 66+
Gender: All