Transcranial direct current stimulation (tDCS) is a form of non-invasive brain stimulation in which low level electrical currents are applied to the scalp in order to alter brain function. In the present study, tDCS will be administered with the goal of assessing the to...

This study will evaluate the safety of oral administration of EcoActive to patients with inactive Crohn's disease and how it affects the levels of AIEC in stool.

The purpose of this study is to learn more about age-related macular degeneration (AMD) by using a new investigational technology, AO-(adaptive optics) OCT (optical coherence tomography) with hyperspectral autofluorescence (AF). While currently there is no cure for AMD,...

AMD affects 15 million Americans, with 200,000 new advanced cases diagnosed each year. AMD is the leading cause of blindness in this country, from either the “dry” or “wet” advanced forms. At present, there is no treatment for dry AMD. Besides bl...

Using Adaptive Optics technology to study high-resolution images of the damaged photoreceptors, which may provide a deeper understanding of the condition that could one day lead to the development of treatments.

Age-related macular degeneration (AMD) is the leading cause of blindness in our country, and heart attack and stroke are leading causes of death. We have discovered that AMD and these lethal systemic diseases may be linked by a special form of AMD called “reticula...

We plan to identify the anatomical, biochemical and genetic differences between normal and glaucomatous eyes using various using tissue samples from the eye and blood.

The primary aim of this study is to evaluate the effect of upgaze on patients with POAG and NTG. Secondary aims of this study will include stratification based on severity of glaucoma or prior surgical interventions, and presence or absence of Bell’s phenomenon.

The primary purpose of this study is to evaluate the efficacy and safety of a single intravenous (IV) re-induction dose of approximately 6 milligram per kilogram (mg/kg) ustekinumab in participants with secondary loss of response (LoR) to subcutaneous (SC) every 8 We...

This study is utilizing electrophysiology, called Visual Evoked Potental (VEP) and pattern Electroretinography (ERG) to measure the electrical activity of the visual pathway. VEP measures the electrical activity of the entire vision system. When light enters the eye, it...

Glaucoma is an eye disease that results in damage to cells in the back of the eye known as the retina and poses a major risk to global public health. Primary open angle glaucoma (POAG) is the most common type of glaucoma in the United States. Exfoliation syndrome (XFS) ...

The purpose of this study is to look at the relationship of small blood vessels (microvascular capillary) abnormalities observed with video nailfold capillaroscopy with primary open-angle glaucoma, normal-tension glaucoma, high tension glaucoma, exfoliative glaucoma and...

To evaluate efficacy, safety, and tolerability of BI 655130 compared to placebo in patients with Generalized Pustular Psoriasis (GPP) presenting with an acute flare of moderate to severe intensity

The purpose of this study is to investigate the surgical outcomes of the micropulse transscleral cyclophotocoagulation (mTSCPC) in patients with uncontrolled glaucoma; analyze intraocular pressure lowering effect; and correlate related treatment parameters pen...

Acute infectious conjunctivitis is a leading cause of ocular morbidity, epidemic eye infection, lost productivity, patient discomfort and in some cases permanent visual compromise. The infectious agent is frequently viral in origin and frequently bacterial in origin wit...

The purpose of this study is to evaluate the effect of Ginkgo biloba extract (GBE) on the number of blood vessels in the back of the eye as well as the amount of blood flow at the nailfold(where the fingernail meets the skin) of the 4th finger in the hand.This finger,...

The overall goal of this study is to enroll pregnant women with type 1 diabetes and follow their glycemic outcomes prospectively throughout pregnancy and into the post-partum period. The investigators anticipate that when compared to subjects using an Artificial pancr...

The purpose of this study is to describe the impact of adding intraoperative video laryngoscopy (IOVL) to intraoperative laryngeal nerve monitoring (IOLNM) during neck procedures when IOLNM is routinely used, including thyroidectomy and re-operative parathyroidectomy...

The primary objective of this study is to determine if an HIV-infected donor liver (HIVD+) transplant is safe with regards to major transplant-related and HIV-related complications

The primary objective is to confirm the specificity of a multi-target stool DNA test (mt-sDNA), Cologuard, in an average risk population, ages 45-49.