Human Epilepsy Project 3
By carrying a careful, large-scale and ambitious prospective study of a cohort of
participants with generalized epilepsy, the study team hopes to clarify the likelihood of
response and remission in this type of epilepsy, and try to explore the underlying biological
...
Age: 13 years - 66+
Gender: All
A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of Imetelstat in Combination With Ruxolitinib in Participants With Myelofibrosis
The purpose of the study is to identify the recommended Part 2 dose (R2PD) of imetelstat in combination with ruxolitinib in participants with myelofibrosis (MF) in Part 1, and to evaluate the safety and clinical activity of the R2PD of imetelstat in combination with rux...
Age: 18 years - 66+
Gender: All
ScreenPlus: A Comprehensive, Flexible, Multi-disorder Newborn Screening Program
ScreenPlus is a consented, multi-disorder pilot newborn screening program implemented in conjunction with the New York State Newborn Screening Program that provides families the option to have their newborn(s) screened for a panel of additional conditions. The study has...
Age: Birth - 66+
Gender: All
Trial Comparing Renal Damage of Thulium to Holmium Laser
This is an ongoing randomized controlled trial of patients undergoing URSLL with unilateral
non-obstructing renal stones. Patients are randomized to undergo URSLL with either the TFL or
Ho:YAG laser. Each patient's urine is collected immediately pre-op (V1), 1 hour ...
Age: 18 years - 66+
Gender: All
A Study of JNJ-68284528 Out-of-Specification (OOS) for Commercial Release in Participants With Multiple Myeloma
The purpose of this study is to evaluate the efficacy and safety of cilta-cel
out-of-specification (OOS).
Age: 18 years - 66+
Gender: All
Circumferential Vertebral Reconstruction of Osteoporotic Compression Fractures Using a Novel Bipedicular Peek Implant
The RECONSTRUCT study is a single site, prospective, single arm, post-market, pilot study to evaluate clinical and radiologic outcome data regarding the use of the Vertebral Implant PEEK (VIP) implant in the treatment of symptomatic, acute (<8week) vertebral compress...
Age: 50 years - 66+
Gender: All
Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy
The number of elderly head-and-neck squamous cell carcinoma (HNSCC) patients is increasing;
however, the evidence regarding the ideal treatment for this often vulnerable and frail
patient cohort is limited. Although the benefit of concomitant chemotherapy has been r...
Age: 65 years - 66+
Gender: All
Pulsenmore ES Device, Efficacy and Safety Assessment
This is a multicenter, prospective, investigational device study designed to evaluate: The safety, feasibility, and accuracy of the device, when used by pregnant individuals
Age: 18 years - 66+
Gender: Female
Kidney Disease After COVID-19
To understand the long-term epidemiology, develop effective risk-prediction and stratification tools, and understand the pathobiology of kidney disease in COVID-19 survivors.
Age: 18 years - 66+
Gender: All
Safety and Efficacy of Lacutamab in Patients With Relapse Peripheral T-cell Lymphoma That Express KIR3DL2
This is a multi-center phase Ib sutdy, which evaluates the safety and efficacy of lacutamab
monotherpy in patients with relapse peripheral T-cell lymphoma that express KIR3DL2.
Age: 18 years - 66+
Gender: All
Posterior cerebraL ArTery Occlusion Study
For this retrospective study, the investigators will collect and analyze data of patients who presented with posterior artery occlusion and underwent mechanical thrombectomy (the type of endovascular stroke treatment) and intravenous thrombolysis (the type of non-endova...
Age: 18 - 89 years
Gender: All
Pilot Trial of Colchicine in Urothelial Cancer and Other Solid Tumors
This open-label, non-randomized study aims to determine the anti-inflammatory effect of colchicine on the reduction of peripheral blood CRP in patients with solid tumors or localized urothelial cancer. There are two cohorts, which will enroll separately and parallelly. ...
Age: 18 years - 66+
Gender: All
The Electronic Medical Records and GEnomics (eMERGE) Network Genomic Risk Assessment
The eMERGE Network embraces the opportunity to use new methods in genomic medicine,
information science, and research participant engagement to identify people at very high risk
for specific diseases and recommend individualized approaches to prevention and care. Th...
Age: 3 - 75 years
Gender: All
MINDS Imaging Ancillary Study
This study is an ancillary study to the NHLBI-funded Pediatric Heart Network (PHN)
"Multi-Institutional Neurocognitive Discovery Study" (MINDS) in Adult Congenital Heart
Disease (ACHD). The MINDS-ACHD" study will recruit 500 complex CHD patients between18-30
years...
Age: 18 - 30 years
Gender: All
Delivering Empowering Conversations About Obstetric Regional Anesthesia for Underserved Minorities
Racial and ethnic disparities in obstetric anesthesia care remains persistent despite studies
documenting its existence and calling for action. The goal of this study is to share
disparity data with underserved minority groups being admitted to the labor and deliver...
Age: 18 years - 66+
Gender: Female
Foley Catheter Induction
The foley catheter (single lumen balloon) is one of the most cost effective, readily available methods for cervical ripening to begin an induction of labor. It is most commonly used in conjunction with oxytocin, a medication given to induce contractions. However, there ...
Age: 18 - 50 years
Gender: All
Assessment of Patients With Acute Pouchitis Treated With Antibiotics
The purpose of this study is to evaluate the reliability and responsiveness of symptoms, endoscopic, and histological items for assessing pouchitis disease activity in patients undergoing standard of care (SOC) antibiotic therapy for treatment of pouchitis, in order to ...
Age: 18 years - 66+
Gender: All
Aveir DR i2i Study
Prospective, non-randomized, multi-center, international study designed to evaluate the
safety and effectiveness of the Aveir™ Dual-Chamber (DR) Leadless Pacemaker system.
Age: 18 years - 66+
Gender: All
The Effect of Structured Lifestyle Modification and Yoga Practice on Metabolic Processes Associated With Cardiovascular Disease
The aim of the prospective randomized single center study is to evaluate the effect of a short-term (16 weeks) yoga program on micro RNA (miRNA) expression and cardiovascular disease (CVD) risk factors in patients with CVD.
Age: 18 - 80 years
Gender: All
Invasive Decoding and Stimulation of Altered Reward Computations in Depression
Novel invasive neurostimulation stimulation strategies through neurosurgical interventions are emerging as a promising therapeutical strategy for major depressive disorder. These have been applied mostly to the anterior cingulate cortex, but other limbic brain regions h...
Age: 18 - 80 years
Gender: All