Spesolimab in Pyoderma Gangrenosum
The purpose of this research study is to assess the feasibility of using spesolimab in participants with moderate to severe pyoderma ganrenosum. Pyoderma gangrenosum is a rare, inflammatory, autoimmune condition which results in ulceration of skin. The study will also i...
Age: 18 years - 66+
Gender: All
MCG Discovery Study in Emergency Departments
This prospective discovery study is designed to demonstrate the feasibility of using an
unshielded, mobile MCG device in an Emergency Department (ED) setting. The main question it
aims to answer is whether interpretable data can be reliably collected as part of an E...
Age: 18 years - 66+
Gender: All
Efficiency and Safety of Holmium Laser With Moses Technology Versus SuperPulsed Laser System With Thulium Fiber Laser on Renal Stones
This is a prospective randomized controlled trial designed to assess the efficacy and safety
of Lumenis® Pulse™ P120H holmium laser system with the Moses technology (holmium laser with
pulse modulation) versus the Soltive™ SuperPulsed Laser System with the thulium f...
Age: 18 - 89 years
Gender: All
Single-dose Ketamine Treatment to Improve Depression in Mild Cognitive Impairment
Ketamine is a NMDA-receptor antagonist that promotes synapse formation and has been shown to
rapidly improve symptoms in depression. Even a single dose of ketamine has been shown to
improve depression and cognition with short-term memory, inhibitory control, cogniti...
Age: 50 - 90 years
Gender: All
Versatility of a Circular Multielectrode Catheter in the Individualized Recognition & Treatment of Atrial Fibrillation and Related Arrhythmias Using Pulsed Field Energy
The purpose of this pragmatic study is to evaluate the safety, performance and effectiveness
of the VARIPULSE catheter technology used in combination with the TRUPULSE™ Generator, and
the compatible EAM system (Carto 3D) to treat patients with atrial fibrillation an...
Age: 18 years - 66+
Gender: All
A Study to Assess Luspatercept in Lower-risk Myelodysplastic Syndrome Participants
The purpose of this study is to evaluate the efficacy and safety of Luspatercept when
administered at the maximum approved dose in low-risk Myelodysplastic Syndrome participants
who require red blood cell transfusions.
Age: 18 years - 66+
Gender: All
PDE4 Inhibition in Seborrheic Dermatitis and Papulopustular Rosacea
This study is a double-blind, vehicle-controlled clinical trial. The study will take place at Icahn School of Medicine at Mount Sinai. The study will include 33-39 adult subjects with moderate-to-severe-Seborrheic dermatitis (SD) as well as 33-39 adult subjects with mod...
Age: 18 years - 66+
Gender: All
A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Idiopathic Pulmonary Fibrosis
The purpose of this study is to evaluate the efficacy, safety, and tolerability of BMS-986278
in participants with Idiopathic Pulmonary Fibrosis.
Age: 40 years - 66+
Gender: All
Safety, Feasibility, and Efficacy of TSCS on Stabilizing Blood Pressure for Acute Inpatients With SCI
This site-specific project will focus on a novel non-pharmacologic approach to stabilizing BP
during AIR after acute traumatic SCI. Current forms of pharmacologic and non-pharmacologic
treatments for hypotension and OH remain inadequate in the SCI population. A crit...
Age: 14 - 100 years
Gender: All
Pregnant Women With and Without Crohns Disease to Explore the Role of Plastics and Toxins in Intestinal Inflammation
The PLANET Study aims to determine the impact of microplastics on intestinal inflammation and
gut microbiome in order to understand the role of this pollutant on the risk of developing
inflammatory bowel disease (IBD) as well as other diseases. With this information...
Age: 18 years - 66+
Gender: All
Longitudinal Cortical Demyelination in Multiple Sclerosis and Related Disorders
In this protocol, a combination of MRI, blood, and cerebrospinal fluid (CSF) analysis will be
used to understand the natural history, underlying immunologic mechanisms, and clinical
implications of central nervous system (CNS) lesions, in particular lesions in the c...
Age: 18 years - 66+
Gender: All
Targeting Drug Memories With Methylphenidate
This study aims to identify the neural, behavioral, and pharmacological mechanisms promoting
diminished expression of drug-related memories in human drug addiction. In this fMRI study
with a within-subjects placebo-controlled double-blind cross-over design, oral
m...
Age: 26 - 50 years
Gender: All
Repigmentation of Stable Vitiligo Lesions Using Spray-On Skin™ Cells
To evaluate repigmentation and quality of life after treatment of stable vitiligo lesions
using the RECELL Device.
Age: 18 years - 66+
Gender: All
Telehealth Cognitive Behavioral Therapy for Youth at Risk for Psychosis
This study aims to evaluate the feasibility and effectiveness of telehealth interventions for individuals at clinical high risk for psychosis (CHR). Psychosis typically emerges during late adolescence or early adulthood, significantly impacting long-term functioning. Wh...
Age: 14 - 25 years
Gender: All
Intraventricular Catheter System for IVH
The purpose of this research study is to evaluate the safety and outcomes associated with the
use of IRRAflow® System catheters in externally draining intracranial fluid to reduce
intracranial pressure. This study will be comparing the IRRAflow® system to standard o...
Age: 18 years - 66+
Gender: All
RECOVER-NEURO: Platform Protocol to Measure the Effects of Cognitive Dysfunction Interventions on Long COVID Symptoms
This platform protocol is designed to be flexible so that it is suitable for a wide range of
settings within health care systems, for remote settings, and in community settings where it
can be integrated into COVID-19 programs and subsequent treatment plans.
Thi...
Age: 18 years - 66+
Gender: All
A Phase 3, SingleArm, OpenLabel Study to Evaluate the Safety and Contraceptive Efficacy of Relugolix Combination Therapy in Women with Uterine Fibroids or Endometriosis who are 18 to 50 Years of Age and at Risk for Pregnancy
The purpose of this study is to evaluate if relugolix, given with low-dose estradiol (estrogen) and norethindrone acetate (progesterone) (referred to as relugolix combination therapy) is safe and works in the prevention of pregnancy in women with uterine fibroids or end...
Age: 18 - 50 years
Gender: Female
A Study of MK-0616 (Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-013) CORALreef Lipids
The goal of this study is to evaluate the efficacy, safety, and tolerability of MK-0616 in
adult participants with hypercholesterolemia. The primary hypothesis is that MK-0616 is
superior to placebo on mean percent change from baseline in low-density lipoprotein
c...
Age: 18 years - 66+
Gender: All
SELUTION 4 De Novo Small Vessel IDE Trial
Prospective, randomized controlled, single-blind, multicenter, clinical trial to demonstrate
the safety and efficacy of the SELUTION SLR 014 PTCA DEB for treatment of de novo lesions in
small coronary vessels, defined as reference vessel diameter (RVD) of 2.00 mm to...
Age: 18 years - 66+
Gender: All
Ascertaining the Radiologic Prognostic Importance of Extranodal Extension on Imaging (iENE) in Head and Neck Cancer
Extranodal extension (ENE) refers to the spread of head and neck squamous cell carcinoma
(HNSCC) outside the lymph nodes. It is a well-known factor that indicates a poorer prognosis
and outcome for patients who have undergone surgical removal of the cancer. In such ...
Age: 18 years - 66+
Gender: All