Paired Vagus Nerve Stimulation in Mobilization of Patients With Prolonged Disorders of Consciousness
Study Phase: N/A
Recruitment Status: Recruiting
Start Date: May 01, 2025
End Date: December 30, 2027
Inclusion Criteria:
- Patients with a diagnosis of pDOC (includes coma, VS/UWS, MCS, MCS +, MCS-) as defined as disorder of consciousness (DOC) greater than 3 months post onset
- Patients deemed medically safe to participate in physical therapy (PT) as evaluated by the study physicians.
Exclusion Criteria:
- Patients who have emerged from MCS (CRS-R score 6 on Motor Function scale and/or 2 on Communication Scale).
- Patients medically unsafe for participation in PT as indicated by one of the study physicians (including but not limited to those receiving intravenous sedation, those with integumentary breakdown or known pressure injuries, those with cardiovascular or cerebrovascular conditions precluding initiation of physical therapy [ie uncontrolled intracranial pressure, severe symptomatic orthostatic hypotension, etc.).
- Patients with DOC less than 3 months post onset will also be excluded.
- Patients who do not meet technical requirements of the RTTM device will be excluded
- weighing greater than 135 kg
- length of legs below 75 cm or above 100 cm,
- fixed contractures of lower extremity including hip, knee, ankle, or foot).
- Does not have an identified care partner or legally authorized representative to consent to participation
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Conditions:
- Brain Injuries
- Consciousness Disorders