Effects of Stereotype Threat on Impulsivity and Its Relation to Alcohol Use in African Americans: An fMRI Study
The purpose of this study is to investigate the behavioral and neural correlates of stress exposure. Results from this study will enrich the understanding of how sociocultural, behavioral, and neural factors combine to influence alcohol use.
Age: 21 - 35 years
Gender: All
Transabdominal Plane (TAP) Blocks for Inguinal Hernia Repairs
The aim of this double-blind clinical trial is to examine outcomes and pain control after surgery in patients who underwent laparoscopic inguinal hernia repair (IHR) with the use of perioperative transabdominal plane (TAP) block. Research Question: Does transabdominal p...
Age: 18 years - 66+
Gender: All
Children's Lifestyle, Diet, and Exercise Intervention - CHILDREN's Project
Cluster randomized trial to evaluate the impact of a health promotion intervention (the SI! - Program NYC) on the adapted Ideal Cardiovascular Health score (aICH) in children enrolled in New York City elementary schools.
Age: 4 years - 66+
Gender: All
A Study of Botensilimab in Participants With Metastatic Pancreatic Cancer
The goal of this clinical trial is to test if the addition of botensilimab to standard
chemotherapy improves the efficacy compared to just chemotherapy alone in participants with
metastatic pancreatic cancer. One group of participants will only receive chemotherapy ...
Age: 18 years - 66+
Gender: All
A Study of Botensilimab and Balstilimab for the Treatment of Colorectal Cancer
This is an open-label, Phase 2, multicenter study to evaluate the efficacy, safety,
tolerability, and pharmacokinetic profiles of botensilimab as monotherapy and in combination
with balstilimab or standard-of-care treatments in participants with refractory metastati...
Age: 18 years - 66+
Gender: All
Duobrii Treatment of Acne Keloidalis Nuchae (AKN)
Acne keloidalis nuchae (AKN) is one of the chronic forms of scarring folliculitis, affecting predominantly the occipital scalp, seen mostly in men of African descent. Duobrii has the advantage of being the only high potency topical steroid-retinoid combination approved ...
Age: 18 years - 66+
Gender: All
7T MRI for Light Therapy in Patients With Mild Cognitive Impairment and Mild AD
The purpose of this research study is to investigate the effect of a light treatment on
sleep, memory and brain function. In people with mild cognitive impairment (MCI) and
Alzheimer's disease, sleep-wake disturbance is evident in up to 60% of patients. This can be
...
Age: 50 - 85 years
Gender: All
Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (OCEAN(a)) - Outcomes Trial
The primary objective of this study is to compare the effect of treatment with olpasiran, to
placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or
urgent coronary revascularization in participants with atherosclerotic cardiovas...
Age: 18 - 85 years
Gender: All
A Phase I Trial of SIM1811-03 in Subjects With Advanced Solid Tumors and Cutaneous T-cell Lymphoma
This is a first in human, open-label, dose escalation and expansion Phase 1 study of SIM1811-03 in adult patients with advanced solid tumors and cutaneous T-cell lymphoma. SIM1811-03 is a first-in-class IgG1-based humanized anti-tumor necrosis factor type 2 receptor (TN...
Age: 18 years - 66+
Gender: All
Sotagliflozin in Heart Failure With Preserved Ejection Fraction (HFpEF) Patients
The clinical benefits of the dual Sodium-Glucose cotransporter (SGLT) 1 and 2-inhibition have
recently been reported in two clinical trials. The SOLOIST reported the benefits of
sotagliflozin in Type-2 Diabetes Mellitus (T2DM) patients hospitalized for worsening of ...
Age: 18 years - 66+
Gender: All
A Study of Modakafusp Alfa in Adult Participants With Multiple Myeloma
The main aims of this study is to test for any side effects from modakafusp alfa in
combination therapy and to determine the recommended dose of combination therapy with
modakafusp. The dose of modakafusp alfa will be increased a little at a time until the
highest...
Age: 18 years - 66+
Gender: All
Dual-Task Cost in Bilateral Hearing Loss
The specific aims of the research study are:
1. Compare single-task gait parameters between individuals with hearing loss (HL) and age
and education matched controls with normal hearing [normal vs moderate-profound hearing
loss (N=23 for each group)]. For that w...
Age: 40 years - 66+
Gender: All
Vancomycin Study in Multiple Sclerosis (MS)
The overall goal of this study is to elucidate a mechanism by which vancomycin modulates the
gut-brain axis in multiple sclerosis (MS). The gut microbiome plays an important role in
autoimmunity, including MS. However, the identity of gut microbes modulating
neuro...
Age: 18 - 45 years
Gender: All
Transcranial Ultrasound Via Sonolucent Cranioplasty After Minimally Invasive Intracerebral Hemorrhage Evacuation
Postoperative rebleeding is a major limitation of surgical evacuation for intracerebral
hemorrhage (ICH). While computed tomography (CT) is the standard of care for postoperative
hematoma cavity monitoring, CT requires significant physical and financial costs. Studi...
Age: 18 years - 66+
Gender: All
Lipid Profile as Predictor of Adverse Maternal and Neonatal Outcomes: A Pilot Study
The purpose of this study is to ascertain lipid profiles during pregnancy, specifically during the 24-28 week gestation and again near term at 36 weeks gestation. The research team are investigating whether lipid profiles can predict adverse maternal and neonatal outcom...
Age: 18 - 45 years
Gender: Female
Study of Tecovirimat for Human Monkeypox Virus
A5418 is a randomized, placebo-controlled, double-blind study to establish the efficacy of
tecovirimat for the treatment of people with laboratory-confirmed or presumptive HMPXV
disease.
Age: Birth - 66+
Gender: All
Cannabinoids for the Reduction of Inflammation and Sickle Cell Related Pain
A randomized, double blind, study of dronabinol as a palliative agent in the treatment of pain, inflammation, and other complications of sickle cell disease (SCD).
Age: 18 years - 66+
Gender: All
Identification of Acute Intermittent Porphyria Modifying Genes
This study proposes to identify the predisposing/protective modifying genes that underlie the acute attacks in symptomatic patients with Acute Intermittent Porphyria (AIP), an autosomal dominant inborn error of heme biosynthesis.
Age: 12 years - 66+
Gender: All
Cognitive Rehabilitation for Post-COVID-19 Cognitive Impairment
This pilot randomized controlled trial is to investigate the feasibility and efficacy of
cognitive rehabilitation for patients with post-COVID-19 cognitive impairment. Additionally,
the study will obtain preliminary data, using rsfMRI, regarding the potential underl...
Age: 18 years - 66+
Gender: All
Vertical Climbing (CLMBR) Exercise for Chronic Low Back Pain
This is a randomized control trial of vertical climbing ergometer exercise for individuals
with chronic low back pain. Using a parallel-arm design, participants will be randomized to 8
weeks of supervised exercise using either the vertical climbing ergometer (CLMBR)...
Age: 18 - 64 years
Gender: All