Melanoma is one of the most dangerous forms of skin cancer. There are approximately 75,000 new cases of melanoma diagnosed and 9,000 melanoma related deaths in the United States each year.

Melanoma may appear on normal skin or could start as a mole that changes in appearance. Melanomas that start on the skin are called cutaneous melanomas. Less commonly, melanoma can originate in other locations such as the eyes (ocular or uveal melanoma) or lining surfaces such as the sinuses or vaginal tract (mucosal melanoma). Over 90 percent of melanomas are caused by mutations in DNA of skin cells called melanocytes, which produce the pigment melanin.

There are various types and stages, and symptoms of cutaneous melanoma.