Mount Sinai Tisch Cancer Center

Comprehensive BRCA Program for Men and Women

Men and women who carry genes that increase the risk of cancer want state-of-the-art, compassionate care. Our experts offer just that at The Mount Sinai Health System’s Comprehensive BRCA Program. Learning that you have a genetic mutation that increases your risk of cancer can be overwhelming. We provide comprehensive care tailored to your needs and those of your family. We can coordinate genetic testing for patients who have not had prior testing.

Genes and Cancer 

Cancer starts when certain cells in the body grow out of control and the body’s normal regulatory mechanisms are not working properly. All cancers develop as a result of mutations or changes in your cells’ genes. Most of these changes are not passed on through the family. Only about 5 percent to 10 percent of cancers are caused by hereditary mutations—genetic mutations that can be passed on through generations.

About the BRCA Genes

BRCA1 and BRCA2 are genes that produce proteins that help repair damaged DNA. Everyone inherits two copies of each gene, one from each parent. If you inherit a mutation of the BRCA1 or BRCA2 gene, you are at an increased lifetime risk for developing certain cancers as compared to someone who does not have a mutation. People who have inherited a mutation in BRCA1 or BRCA2 also tend to develop cancer at younger ages than people who do not have a mutation. However, having a mutation does not mean that you will definitely develop cancer.

Women with a BRCA1 or BRCA2 mutation are at increased risk of developing breast cancer and ovarian cancer, as well as fallopian tube cancer and primary peritoneal cancer, both of which start in the same cells as the most common type of ovarian cancer. Men with BRCA2 mutations, and to a lesser extent BRCA1 mutations, are at increased risk of developing prostate cancer and male breast cancer. Both men and women with a BRCA1 or BRCA2 mutation are at increased risk of developing pancreatic cancer. A mutation in the BRCA2 gene is associated with an increased lifetime risk of developing melanoma.


If one parent has a BRCA mutation, each of their children has a 50 percent chance of inheriting the same mutation, and a 50 percent chance of not inheriting it. This is true for each child the parents have.

A BRCA mutation can be passed down from the mother’s or father’s family. For example, a daughter can inherit a mutated BRCA gene from her mother’s or her father’s family that puts her at risk for developing breast cancer or ovarian cancer. Similarly, a son can inherit a mutated BRCA gene from his mother’s or his father’s family that puts him at risk of developing prostate cancer.

What is my Risk?

Take the BRCA Risk Evaluator survey today:

BRCA Risk Evaluator

Next Steps

For more information on genetic testing and counseling and to make an appointment with a specialist, visit our Cancer Genetic Counseling Program here.

If you have already undergone genetic testing and have been found to carry a mutation in the BRCA1 or BRCA2 gene and are interested in a comprehensive plan for screening and treatment, request a personalized Mount Sinai Comprehensive BRCA Program appointment here.

Or, call us at 877-309-BRCA (2722).