Vagal Nerve Stimulation in Enhanced Stroke Recovery: The VALOR Registry
Vagal Nerve Stimulation is a novel proven therapy for patients with chronic ischemic stroke. The primary objective of this registry is to assess the safety of vagal nerve stimulation for stroke recovery through monitoring the occurrence of serious adverse events associa...
Age: 18 years - 66+
Gender: All
Posterior cerebraL ArTery Occlusion Study
For this retrospective study, the investigators will collect and analyze data of patients who presented with posterior artery occlusion and underwent mechanical thrombectomy (the type of endovascular stroke treatment) and intravenous thrombolysis (the type of non-endova...
Age: 18 - 89 years
Gender: All
Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis
The primary goal of the trial is to determine if the experimental arms (rivaroxaban or
ticagrelor or both) are superior to the clopidogrel arm for lowering the 1-year rate of
ischemic stroke, intracerebral hemorrhage, or vascular death.
Age: 30 - 80 years
Gender: All
COMMAND Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis
The Synchron motor neuroprosthesis (MNP) is intended to be used in subjects with severe motor
impairment, unresponsive to medical or rehabilitative therapy and a persistent functioning
motor cortex. The purpose of this research is to evaluate safety and feasibility....
Age: 21 - 75 years
Gender: All
Stroke Thrombectomy and Aneurysm Registry
This international multi-center registry will be used to collect existing information and outcomes for patients undergoing an operation for treatment of injuries to the brain including the blockage of blood flow to an area of the brain, an abnormal ballooning of an arte...
Age: Birth - 120 years
Gender: All
Stroke Thrombectomy and Aneurysm Registry
This international multi-center registry will be used to collect existing information and outcomes for patients undergoing an operation for treatment of injuries to the brain including the blockage of blood flow to an area of the brain, an abnormal ballooning of an arte...
Age: Birth - 120 years
Gender: All
Amplatzer Amulet LAAO vs. NOAC
The objective of this trial is to evaluate the safety and effectiveness of the Amulet LAA
occluder compared to NOAC therapy in patients with non-valvular AF at increased risk for
ischemic stroke and who are recommended for long-term NOAC therapy.
The clinical in...
Age: 18 years - 66+
Gender: All
Endovascular Therapy for Low NIHSS Ischemic Strokes
This study will test the hypothesis that patients presenting within 8 hours of onset with
cerebral ischemia in the setting of proximal large vessel occlusions (LVO) and low baseline
NIHSS scores (0-5) will have better 90-day clinical outcomes (mRS distribution) with...
Age: 18 years - 66+
Gender: All
The Imperative Trial: Treatment of Acute Ischemic Stroke With the Zoom Reperfusion System
The trial is designed to assess the safety and efficacy of using the Zoom Reperfusion System
in subjects diagnosed with acute ischemic stroke and undergoing a thrombectomy procedure
within 8 hours of last known well.
Age: 18 years - 66+
Gender: All
Study to Compare the Efficacy and Safety of NT 201 (Botulinum Toxin) With Placebo for the Treatment of Lower Limb Spasticity Caused by Stroke or Traumatic Brain Injury
The purpose of this study is to determine whether a single treatment with administration of
400 Units NT 201 (botulinum toxin) is superior to placebo (no medicine) for the treatment of
lower limb spasticity caused by stroke or traumatic brain injury (Main Period). P...
Age: 18 - 85 years
Gender: All
Anticoagulation in ICH Survivors for Stroke Prevention and Recovery
Primary Aim: To determine if apixaban is superior to aspirin for prevention of the composite
outcome of any stroke (hemorrhagic or ischemic) or death from any cause in patients with
recent ICH and atrial fibrillation (AF).
Secondary Aim: To determine if apixaban...
Age: 18 years - 66+
Gender: All
XIENCE 28 USA Study
The XIENCE 28 USA Study is prospective, single arm, multi-center, open label, non-randomized trial to evaluate safety of 1-month (as short as 28 days) dual antiplatelet therapy (DAPT) in subjects at high risk of bleeding (HBR) undergoing percutaneous coronary interventi...
Age: 18 - 100 years
Gender: All
IIT Age-related Macular Degeneration (AMD) and Cardiovascular Disease
Age-related macular degeneration (AMD) is the leading cause of blindness in our country, and heart attack and stroke are leading causes of death. We have discovered that AMD and these lethal systemic diseases may be linked by a special form of AMD called “reticula...
Age: 40 - 75 years
Gender: All
CERENOVUS Neurothrombectomy Devices Registry
A post-market registry evaluating the EmboTrap® Revascularization Device and CERENOVUS Large
Bore Catheter/ EMBOVAC Aspiration Catheter in acute ischemic stroke patients with confirmed
intracranial large vessel occlusion.
Age: 18 years - 66+
Gender: All
Treatment in Thoracic Aortic Aneurysm: Surgery vs Surveillance
The ascending aorta conducts blood from the heart to the rest of the body. The ascending
aorta can become enlarged, and the risk of tearing and rupturing becomes higher with larger
aorta. When the ascending aorta tears or ruptures, the risk dying is high even if sur...
Age: 18 - 79 years
Gender: All
Treatment in Thoracic Aortic Aneurysm: Surgery vs Surveillance
The ascending aorta conducts blood from the heart to the rest of the body. The ascending
aorta can become enlarged, and the risk of tearing and rupturing becomes higher with larger
aorta. When the ascending aorta tears or ruptures, the risk dying is high even if sur...
Age: 18 - 79 years
Gender: All
Randomization of Single vs Multiple Arterial Grafts
The primary hypothesis of ROMA is that in patients undergoing primary isolated non-emergent
coronary artery bypass surgery (CABG), the use of two or more arterial grafts compared to a
single arterial graft is associated with a reduction in the composite outcome of d...
Age: 18 - 70 years
Gender: All
Volumetric Integral Phase-shift Spectroscopy for Noninvasive Detection of Hemispheric Bioimpedance Asymmetry in Acute Brain Pathology
The purpose of this study is to assess the ability of the Fluids Monitor to detect
hemispheric bioimpedance asymmetry associated with acute brain pathology in patients
presenting with suspected Acute Ischemic Stroke (AIS).
Age: 18 years - 66+
Gender: All
Assessment of the WATCHMAN™ Device in Patients Unsuitable for Oral Anticoagulation
The purpose of this study is to establish the safety and effectiveness of the WATCHMAN™ Left Atrial Appendage Closure (LAAC) Device, including the post-implant medication regimen, for subjects with non-valvular atrial fibrillation who are deemed not to be eligible...
Age: 18 years - 66+
Gender: All
Feasibility Study of a Left Atrial Appendage Closure Device in Patients With Atrial Fibrillation
The purpose of this study is to assess the safety and function of the Aegis Sierra Ligation
System in accessing and closing off the left atrial appendage (LAA) using a minimally
invasive epicardial access approach.
A minimum of 30 participants will be included in thi...
Age: 18 years - 66+
Gender: All