A Study to Test Asundexian for Preventing a Stroke Caused by a Clot in Participants After an Acute Ischemic Stroke or After a High-risk Transient Ischemic Attack, a So-called Mini Stroke
Researchers are looking for a better way to prevent an ischemic stroke which occurs when a
blood clot travelled to the brain in people who within the last 72 hours had:
- an acute stroke due to a blood clot that formed outside the heart (acute
non-cardioembolic ...
Age: 18 years - 66+
Gender: All
Imaging Coronary Microvascular Dysfunction (CMD) Study
Angina is a common clinical symptom of ischemic heart disease, affecting up to 11 million
people in the United States alone, and 112 million people globally. Despite this, 4 in 10
patients undergoing elective coronary angiography for angina and ischemia do not have
...
Age: 18 years - 66+
Gender: All
Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)
This is a multicenter trial to establish the efficacy of cooling and the optimal duration of
induced hypothermia for neuroprotection in pediatric comatose survivors of cardiac arrest.
The study team hypothesizes that longer durations of cooling may improve either ...
Age: 2 days - 17 years
Gender: All
PROMISE III: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia
A prospective, single-arm, multi-center study designed to gather additional information on
the LimFlow System.
Age: 18 - 95 years
Gender: All
The Effect of Structured Lifestyle Modification and Yoga Practice on Metabolic Processes Associated With Cardiovascular Disease
The aim of the prospective randomized single center study is to evaluate the effect of a
short-term (16 weeks) yoga program on micro RNA (miRNA) expression and cardiovascular disease
(CVD) risk factors in patients with CVD.
Age: 18 - 80 years
Gender: All
Distal Ischemic Stroke Treatment With Adjustable Low-profile Stentriever
The objective of the DISTALS Study is to evaluate the safety and effectiveness of the
Tigertriever 13 Revascularization Device in restoring blood flow in the neurovasculature by
removing thrombus in patients presenting within 24 hours of onset with an ischemic strok...
Age: 18 - 85 years
Gender: All
Efficacy of the COronary SInus Reducer in Patients With Refractory Angina II
To demonstrate the safety and effectiveness of the Reducer system for treatment of patients
with refractory angina pectoris treated with maximally tolerated guideline-directed medical
therapy who demonstrate objective evidence of reversible myocardial ischemia in th...
Age: 18 years - 66+
Gender: All
Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement
Patients undergoing transcatheter aortic valve replacement (TAVR) often have concomitant
coronary artery disease (CAD) which may adversely affect prognosis. There is uncertainty
about the benefits and the optimal timing of revascularization for such patients. There ...
Age: Birth - 66+
Gender: All
Endovascular Therapy for Low NIHSS Ischemic Strokes
This study will test the hypothesis that patients presenting within 8 hours of onset with
cerebral ischemia in the setting of proximal large vessel occlusions (LVO) and low baseline
NIHSS scores (0-5) will have better 90-day clinical outcomes (mRS distribution) with...
Age: 18 years - 66+
Gender: All
The Imperative Trial: Treatment of Acute Ischemic Stroke With the Zoom Reperfusion System
The trial is designed to assess the safety and efficacy of using the Zoom Reperfusion System
in subjects diagnosed with acute ischemic stroke and undergoing a thrombectomy procedure
within 8 hours of last known well.
Age: 18 years - 66+
Gender: All
XIENCE 28 USA Study
The XIENCE 28 USA Study is prospective, single arm, multi-center, open label, non-randomized trial to evaluate safety of 1-month (as short as 28 days) dual antiplatelet therapy (DAPT) in subjects at high risk of bleeding (HBR) undergoing percutaneous coronary interventi...
Age: 18 - 100 years
Gender: All
A Medical Research Study to Evaluate the Effects of ACT-246475 in Adults With Coronary Artery Disease
The goal of this study is to find out if a drug called ACT-246475 can prevent platelets from
binding together when administered by an injection under the skin in the thigh or in the
belly. Another goal is to know how fast and for how long ACT-246475 works and if there...
Age: 18 - 85 years
Gender: All
Supporting Patients Undergoing HIgh-Risk PCI Using a High-Flow PErcutaneous Left Ventricular Support Device (SHIELD II)
The HeartMate PHP System is a temporary (<6 hours) ventricular assist device indicated for
use during high-risk percutaneous coronary interventions (PCI) performed electively or
urgently in hemodynamically stable patients with severe coronary artery disease, when a he...
Age: 18 - 100 years
Gender: All